Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy

Abstract

Hypoxia-based agents (HBAs), such as anaerobic bacteria and bioreductive prodrugs, require both a permeable and hypoxic intratumoural environment to be fully effective. To solve this problem, herein, we report that perfluorocarbon nanoparticles (PNPs) can be used to create a long-lasting, penetrable and hypoxic tumour microenvironment for ensuring both the delivery and activation of subsequently administered HBAs. In addition to the increased permeability and enhanced hypoxia caused by the PNPs, the PNPs can be retained to further achieve the long-term inhibition of intratumoural O 2 reperfusion while enhancing HBA accumulation for over 24 h. Therefore, perfluorocarbon materials may have great potential for reigniting clinical research on hypoxia-based drugs.

Enhanced antitumor efficacy in colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon

“…In our study, PLGA NPs coloaded with 5Fu and PFC showed additive antitumor effects against colon cancer, which was likely due in part to PFC-mediated diffusion of oxygen into the tumor tissue. These findings agreed with previous studies that PFC could inhibit intratumoral hypoxia [29,30].…”

Enhanced antitumor efficacy on colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon

“…In our study, dualloaded PLGA NPs encapsulating 5FU and PFC had the combinative antitumor effects on colon cancer, likely owing to that PFC in the tumor altered the diffusion status of the oxygen in tumor tissue. This was in agreement with the existing researches that PFC had great potential for enhancing intratumoral hypoxia [29,30].…”

Enhanced antitumor efficacy on colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon

“…In our study, dual-loaded PLGA NPs encapsulating 5FU and PFC had the combinative antitumor effects on colon cancer, likely owing to that PFC in the tumor altered the diffusion status of the oxygen in tumor tissue. This was in agreement with the existing researches that PFC had great potential for enhancing intratumoral hypoxia [30,31].…”