Perfluorocarbon Nanoparticles for Molecular Imaging and Targeted Therapeutics

Hughes, Michael S.; Caruthers, Shelton D.; Tran, Trung; Marsh, Jon N.; Wallace, Kirk; Cyrus, Tillmann; Partlow, Kathryn C.; Scott, Michael J.; Lijowski, M.; Neubauer, Anne M.; Winter, Patrick M.; Hu, Grace; Zhang, Hyuing; McCarthy, John E.; Maurizi, Brian; Allen, John S.; Caradine, C.; Neumann, Robert; Arbeit, Jeffrey M.; Lanza, Gregory M.; Wickline, Samuel A.

doi:10.1109/jproc.2007.913500

Cited by 18 publications

(15 citation statements)

References 66 publications

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“…only measurements above the noise level are displayed. has been demonstrated for several applications [18], [32], [33]. Their nanometric size range enables their progressive accumulation in tumors by the EPr effect.…”

Section: Discussionmentioning

confidence: 99%

High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules

Jafari

Diou

Mamou

et al. 2014

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Liquid-core nanoparticles are promising candidates for targeted ultrasound-controlled therapy, but their acoustic detection remains challenging. High-frequency (20 to 40 MHz) tone burst sequences were implemented with a programmable ultrasound biomicroscope to characterize acoustic response from perfluorooctyl bromide-core nanoparticles with thick poly(lactide-coglycolide) (PLGA) shells. Radio-frequency signals were acquired from flowing solutions of nanoparticles with two different shell-thickness-to-particle-radius ratios, solid PLGA nanoparticles, and latex nanobeads (linear controls). Normalized fundamental (20 MHz) and second-harmonic power spectral density (PSD) increased with particle concentration and was highest for the thinnest shelled particles. The second- harmonic PSD was detectable from the nanoparticles for peak rarefactional pressures (PRP) from 0.97 to 2.01 MPa at 23 cycles and for tone bursts from 11 to 23 cycles at 2.01 MPa. Their second-harmonic¿to¿fundamental ratio increased as a function of PRP and number of cycles. Within the same PRP and cycle ranges, the second-harmonic¿to¿fundamental ratios from matched concentration solutions of latex nanobeads and solid PLGA nanoparticles was more weakly detectable but also increased with PRP and number of cycles. Nanoparticles were detectable under flow conditions in vitro using the contrast agent mode of a high-frequency commercial scanner. These results characterize linear acoustic response from the nanoparticles (20 to 40 MHz) and demonstrate potential for their highfrequency detection.

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Section: Discussionmentioning

confidence: 99%

High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules

Jafari

Diou

Mamou

et al. 2014

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…97–99 In a genetic model of squamous cell carcinoma, extremely limited extents of inflammatory neovasculature could be demonstrated in the mouse pinna with high resolution ultrasound imaging systems and special signal processing algorithms that harbor quantitative potential based on the "information content" of the data stream. 98–100 Both pathological (e.g., atherosclerosis, cancer, inflammation) and tissue reparative processes (e.g., recovery from ischemic injury) invoke significant angiogenesis that might be candidates for renal imaging,…”

Section: Elucidation Of Kidney Function and Injury With Pfc Npmentioning

confidence: 99%

Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy

Chen

Pan

Lanza

et al. 2013

Advances in Chronic Kidney Disease

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Herein we review the use of non-nephrotoxic perfluorocarbon nanoparticles (PFC NP) for noninvasive detection and therapy of kidney diseases, and provide a synopsis of other related literature pertinent to anticipated clinical application. Recent reports indicate that PFC NP allow quantitative mapping of kidney perfusion, and oxygenation after ischemia-reperfusion injury with the use of a novel multi-nuclear 1H/19F magnetic resonance imaging (MRI) approach,. Furthermore, when conjugated with targeting ligands, the functionalized PFC NP offer unique and quantitative capabilities for imaging inflammation in the kidney of atherosclerotic ApoE-null mice. Additionally, PFC NP can facilitate drug delivery for treatment of inflammation, thrombosis, and angiogenesis in selected conditions that are comorbidities for to kidney failure. The excellent safety profile of PFC NP with respect to kidney injury positions these nanomedicine approaches as promising diagnostic and therapeutic candidates for treating and following acute and chronic kidney diseases.

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“…Nanoscale PFC particles are typically lipid- or surfactant-stabilized nanodroplets of PFC created by self-assembly and emulsion techniques [61]. Sizes for PFC nanoparticles generally range from 200 nm to 250 nm [17, 20].…”

Section: Nanocarriers For Targeting Imaging Agents and Drugs To Acmentioning

confidence: 99%

“…Different PFCs can be used in the liquid core, including perfluorodichlorooctane, perfluoro 15-crown-5-ether, and most commonly, perfluorooctyl bromide (PFOB). In the PFOB nanoparticle systems described by Lanza, Wickline and colleagues, the liquid PFC core represents 98% of the total particle volume, affording a substantial 19 F concentration (~100 M) [61, 63] for sensitive detection by MRI techniques.…”

Section: Nanocarriers For Targeting Imaging Agents and Drugs To Acmentioning

confidence: 99%

Targeted nanocarriers for imaging and therapy of vascular inflammation

Chacko

Hood

Zern

et al. 2011

Current Opinion in Colloid & Interface Science

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Vascular inflammation is a common, complex mechanism involved in pathogenesis of a plethora of disease conditions including ischemia-reperfusion, atherosclerosis, restenosis and stroke. Specific targeting of imaging probes and drugs to endothelial cells in inflammation sites holds promise to improve management of these conditions. Nanocarriers of diverse compositions and geometries, targeted with ligands to endothelial adhesion molecules exposed in inflammation foci are devised for this goal. Imaging modalities that employ these nanoparticle probes include radioisotope imaging, MRI and ultrasound that are translatable from animal to human studies, as well as optical imaging modalities that at the present time are more confined to animal studies. Therapeutic cargoes for these drug delivery systems include diverse anti-inflammatory agents, anti-proliferative drugs for prevention of restenosis, and antioxidants. This article reviews recent advances in the area of image-guided translation of targeted nanocarrier diagnostics and therapeutics in nanomedicine.

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Perfluorocarbon Nanoparticles for Molecular Imaging and Targeted Therapeutics

Cited by 18 publications

References 66 publications

High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules

High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules

Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy

Targeted nanocarriers for imaging and therapy of vascular inflammation

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