Perfluorocarbon emulsion improves oxygenation  of the cat primary visual cortex

Padnick, Lissa B.; Linsenmeier, Robert A.; Goldstick, Thomas K.

doi:10.1152/jappl.1999.86.5.1497

Cited by 14 publications

(7 citation statements)

References 33 publications

(45 reference statements)

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“…Increases in cerebral ptiO 2 in normal brain have been demonstrated with a similar but more concentrated PFC emulsion from Alliance (AF0104; 0.9 g perflubron/1.0 ml) administered with short periods of 100% O 2 (36). Instead of a series of O 2 challenges, however, the current study used 100% O 2 during the entire treatment phase of the study to model its use in the critical care setting, where extended increases in the fraction of inspired oxygen may be appropriate in patients with critically low cerebral ptiO 2 (30,31).…”

Section: Tissue Oxygen Tensionmentioning

confidence: 85%

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&NA;

2004

Neurosurgery

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OBJECTIVE: Cerebral ischemia is a common secondary sequela of traumatic brain injury (TBI). Experimental models of stroke have demonstrated reductions in ischemia after perfluorocarbon (PFC) administration; however, there are no published reports of PFC efficacy after TBI. The current study analyzed the effect of the PFC emulsion Oxygent (AF0144; Alliance Pharmaceutical Corp., San Diego, CA) on cerebral oxygenation, mitochondrial redox potential, and free radical formation after lateral fluid percussion injury. METHODS: After fluid percussion injury, five 2.25 ml/kg doses of PFC or saline were administered to rats breathing 100% O 2 , and oxygen tension was recorded. In a second experiment, a single bolus (11.25 ml/kg) of PFC or saline was given after injury, and redox potential and free radical formation were measured at 1 or 4 hours with Alamar blue dye and dihydrorhodamine 123, respectively. RESULTS: Cerebral oxygen tension was significantly increased in both injured and sham animals treated with 11.25 ml/kg of PFC as compared with saline (P Ͻ 0.05). Likewise, PFC significantly increased mitochondrial redox potential as compared with saline at 4 hours after injury (P Ͻ 0.01). Mitochondrial peroxynitrite and peroxide production also increased with the administration of PFC (P Ͻ 0.05). CONCLUSION: The current study demonstrates that a PFC emulsion can significantly increase cerebral oxygenation after TBI and enhance mitochondrial function at 4 hours after injury as compared with saline. This study demonstrates a new therapeutic potential for PFC to enhance cerebral oxygenation and aerobic metabolism after TBI. However, the increased free radical formation with high-dose PFCs suggests the need for further studies combining PFCs with free radical scavengers.

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Section: Tissue Oxygen Tensionmentioning

confidence: 85%

“…With the addition of PFCs, however, the transport of O 2 can be expanded to the entire surface area of the capillary (36). Under normal conditions, most capillaries are perfused by a "single file" column of RBCs known as rouleaux with limited O 2 transport by the plasma.…”

Section: Tissue Oxygen Tensionmentioning

confidence: 99%

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&NA;

2004

Neurosurgery

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“…Braun et al 19 showed that there was no change in retinal oxygen consumption after administration of perflubron emulsion. Padnick et al 20 found that the infusion of perflubron emulsion had no effect on systemic hemodynamics, cerebral blood flow, or cortical electrical activity.…”

Section: Discussionmentioning

confidence: 99%

“…Perflubron emulsion (5.4 g PFC/kg) has been shown to significantly increase brain cortex oxygen tension in unanesthetized rabbits breathing 100 percent oxygen 22 . Padnick et al 20 showed that the infusion of perflubron emulsion (1 g PFC/kg) and 100 percent oxygen significantly increased tissue oxygen tension in the primary visual cortex of anesthetized normovolemic cats.…”

Section: Discussionmentioning

confidence: 99%

Perflubron emulsion increases subcutaneous tissue oxygen tension in rats

Rosen

Hopf

Hunt

2006

Wound Repair Regeneration

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Oxygen plays a central role in wound healing. The hypothesis of this study was that the administration of a perfluorocarbon emulsion, which dissolves oxygen will increase subcutaneous tissue oxygen tension (PsqO2) in normovolemic and hemorrhaged animals. In the first set of experiments, PsqO2 was measured with a polarographic oxygen electrode along the dorsum of normovolemic-anesthetized rats (n=20) breathing supplemental oxygen. After baseline equilibration of tissue oxygen tension, perflubron emulsion (n=12) or saline control (n=8) was administered. Perflubron administration increased PsqO2 by 32.0 +/- 7.2 mmHg, whereas saline administration had no effect (-1.0 +/- 6.6 mmHg). In a second set of experiments, PsqO2 (n=12) was measured in rats breathing 100 percent oxygen after being bled 20 percent of their blood volume. Creating hypovolemic rats allowed for the study of the effect of perflubron emulsion administration on subcutaneous oxygen tension in tissues with compromised blood flow. Perflubron emulsion was only effective at increasing oxygen tension in tissues with oxygen extractions less then 2.0 vol%. These findings agree with those results analytically predicted based on the oxygen solubility of the perflubron emulsion.

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“…Perfluorocarbon with high affinity to oxygen has been demonstrated as promising O 2 shuttle to fight against hypoxic intratumor microenvironment so as to enhance the efficacy of some treatments such as RT and PDT. It is well known that PDT is strongly oxygen dependent because the PDT‐induced single oxygen ( 1 O 2 ) typically originates from oxygen molecules, which means that the therapeutic efficacy of PDT is substantially hindered by the tumor hypoxia .…”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex

Cited by 14 publications

References 33 publications

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Perflubron emulsion increases subcutaneous tissue oxygen tension in rats

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

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