Perfluoroalkyl substances in older male anglers in Wisconsin

Christensen, Krista; Raymond, Michelle; Thompson, Barbara; Anderson, Henry A.

doi:10.1016/j.envint.2016.03.012

Cited by 72 publications

(54 citation statements)

References 28 publications

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“…The other two studies focused on children and adolescents with background exposure to PFAS [11,18], yielding con icting results: while Geiger et al (n = 1655) found no evidence of an association between serum PFAS and blood pressure or hypertension [18], Ma et al (n = 2251) found a positive signi cant association between PFOS and DBP among males [11]. Other cross-sectional studies with smaller sample size (range n = 48 -187) reported positive [10,13], null [15,17] or negative associations [16]. A study on highly exposed Chinese adults (China C8 Health Project, n = 1612) investigated the association between blood pressure and several PFAS congeners, including linear and branched isomers [9].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in the general population [9][10][11][12][13][14], and just one on 500 highly exposed individuals in China [9] found positive associations between serum PFAS concentrations and hypertension. However, these ndings were not demonstrated in other cross sectional studies [15][16][17][18][19][20], nor in two longitudinal studies on hypertension [21] and one on blood pressure trajectory [22]. The association of serum PFAS with blood pressure as a continuous outcome was evaluated in few cross-sectional studies, but with con icting ndings [9,11,12,14].…”

Section: Introductionmentioning

confidence: 94%

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Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

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BackgroundResidents in a large area of North-Eastern Italy were exposed to perfluoroalkyl substances (PFAS) via drinking water. Studies on the association between PFAS and blood pressure levels are limited, and results are inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence.MethodsThe study comprised 16,224 individuals aged 20-39 years. Pregnant women (n=327), or individuals with missing information on the selected covariates (n=111) were excluded, leaving 15,786 subjects for the analyses. Hypertension was defined as any self-reported diagnosis, use of antihypertensive drugs, or elevated systolic blood pressure (SBP≥140 mmHg)/diastolic blood pressure (DBP≥90 mmHg). Generalized additive models were used to investigate the relation between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) natural log (ln) transformed and by decile, and SBP, DBP, hypertension, adjusted for potential confounders.ResultsBoth SBP and DBP increased significantly with an increase in the ln-transformed serum PFAS concentrations in a monotonic way. The predicted increase in SBP and DBP were 1.54 mmHg (95%CI 0.61-2.47), 1.60 mmHg (95%CI 0.92-2.27) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and for DBP in women. One unit increase in each In-transformed PFAS was positively associated with an increased odd of hypertension in men: PFOA OR=1.06 (1.01-1.11), PFOS OR=1.13 (1.03-1.23), PFHxS OR=1.08 (1.02-1.15), PFNA OR=1.20 (1.02-1.40).ConclusionsOur findings suggest that serum PFAS concentrations were associated with increased systolic and diastolic blood pressure in a large highly exposed young adult population. Although the magnitude of the observed effect was relatively small, if confirmed it would be of public health relevance since even small increases in blood pressure levels at the population level may be associated to a raised risk of adverse outcomes such as cardiovascular disease and target organ damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Despite the evidence indicating potentially obesogenic and diabetogenic effects of PFASs, most data linking PFAS exposure with T2D are derived from cross-sectional studies, with equivocal findings ( Cardenas et al. 2017 ; Christensen et al. 2016 ; Conway et al.…”

Section: Introductionmentioning

confidence: 99%

Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among U.S. Women

Sun

Zong

Valvi

et al. 2018

Environ Health Perspect

126

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Background:Emerging evidence suggests that perfluoroalkyl substances (PFASs) are endocrine disruptors and may contribute to the etiology of type 2 diabetes (T2D), but this hypothesis needs to be clarified in prospective human studies.Objectives:Our objective was to examine the associations between PFAS exposures and subsequent incidence of T2D in the Nurses’ Health Study II (NHSII). In addition, we aimed to evaluate potential demographic and lifestyle determinants of plasma PFAS concentrations.Methods:A prospective nested case–control study of T2D was conducted among participants who were free of diabetes, cardiovascular disease, and cancer in 1995–2000 [(mean±SD): 45.3±4.4y) of age]. We identified and ascertained 793 incident T2D cases through 2011 (mean±SD) years of follow-up: 6.7±3.7y). Each case was individually matched to a control (on age, month and fasting status at sample collection, and menopausal status and hormone replacement therapy). Plasma concentrations of five major PFASs, including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonate, perfluorononanoic acid, and perfluorodecanoic acid were measured. Odds ratios (ORs) of T2D by PFAS tertiles were estimated by conditional logistic regression.Results:Shorter breastfeeding duration and higher intake of certain foods, such as seafood and popcorn, were significantly associated with higher plasma concentrations of PFASs among controls. After multivariate adjustment for T2D risk factors, including body mass index, family history, physical activity, and other covariates, higher plasma concentrations of PFOS and PFOA were associated with an elevated risk of T2D. Comparing extreme tertiles of PFOS or PFOA, ORs were 1.62 (95% CI: 1.09, 2.41; ptrend=0.02) and 1.54 (95% CI: 1.04, 2.28; ptrend=0.03), respectively. Other PFASs were not clearly associated with T2D risk.Conclusions:Background exposures to PFASs in the late 1990s were associated with higher T2D risk during the following years in a prospective case–control study of women from the NHSII. These findings support a potential diabetogenic effect of PFAS exposures. https://doi.org/10.1289/EHP2619

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“…10 High concentrations of PFAS have been both positively and inversely linked with diabetes, with both significant and non-significant associations observed for the inverse relationships. [11][12][13][14] Mixed results have been observed for the relationship of PFAS with ischemic heart disease, with null 8,15 to inverse relationships observed. 16 For cerebrovascular disease, specifically stroke, two studies have examined the relationship of the PFAS perfluorooctanoic acid (PFOA) in worker populations, with one study observing an apparent protective relationship for stroke mortality 17 and the other suggesting a positive relationship.…”

Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl substances and likelihood of stroke in persons with and without diabetes

Hutcheson

Innes

Conway

2019

Diabetes and Vascular Disease Research

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Objective: The main objective of this study is to evaluate the relationship of perfluoroalkyl substances with stroke and any modifying influence of diabetes. Methods: Data on 3921 adults aged ⩾20 years with and 44,285 without diabetes were drawn from the C8 Health Project. Four perfluoroalkyl substances were investigated: perfluorohexane sulphate, C8 – perfluorooctanoic acid, perfluoroctane sulfonate and perfluorononaoic acid. Results: There were 238 cases of stroke among those with and 643 among those without diabetes. In analyses controlled for age, sex, race, diabetes duration, body mass index, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, kidney function and a history of smoking, a history of stroke was significantly inversely associated with serum perfluorohexane sulphate (odds ratio = 0.75, 0.64–0.88) and perfluoroctane sulfonate (odds ratio = 0.81, 0.70–0.90), but not perfluorooctanoic acid (odds ratio = 1.04, 0.94–1.15) or perfluorononaoic acid (odds ratio = 0.89, 0.70–1.14) among those with diabetes. Perfluoroalkyl substances demonstrated no association with stroke among those without diabetes ( p interaction = 0.006 and 0.01 for perfluorohexane sulphate and perfluorooctanoic acid, respectively). Conclusion: In this large cross-sectional study, serum levels of perfluorohexane sulphate and perfluoroctane sulfonate were inversely associated with stroke among those with diabetes. Although mechanisms and implications for this diabetes-specific inverse relationship need to be further explored, our data suggest that perfluoroalkyl substances do not increase risk of stroke among persons with or without diabetes.

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Perfluoroalkyl substances in older male anglers in Wisconsin

Cited by 72 publications

References 28 publications

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among U.S. Women

Perfluoroalkyl substances and likelihood of stroke in persons with and without diabetes

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