Perfluoroalkyl substances in adolescents in northern Norway: Lifestyle and dietary predictors. The Tromsø study, Fit Futures 1

Averina, Maria; Brox, Jan; Huber, Sandra; Furberg, Anne‐Sofie

doi:10.1016/j.envint.2018.02.031

Cited by 57 publications

(37 citation statements)

References 59 publications

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“…Concentrations of individual PFAS that were measured in donor serum with a detection frequency of 100% are shown in Table . PFAS concentrations in general were not high in this donor population compared to the 97.5 percentile concentrations derived from the Fit Futures study of the young general population from Tromsø . Only 0.3% to 4.5% of the donors were above 97.5 percentile concentrations of different PFAS measured in the Fit Futures study of teenagers .…”

Section: Resultscontrasting

confidence: 57%

“…Therefore, we chose a young and relatively healthy general Norwegian population without occupational exposure to PFAS for the comparison. The 97.5 percentile of serum PFHxS, PFNA and PFDA concentrations measured in Norwegian adolescents (15‐19 years old) from the Fit Futures study were applied as thresholds: 7.66 ng/mL for PFHxS, 1.61 ng/mL for PFNA and 0.79 ng/mL for PFDA …”

Section: Methodsmentioning

confidence: 99%

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Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

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Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants.

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Section: Resultscontrasting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

Self Cite

View full text Add to dashboard Cite

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“…Shellfish showed the strongest correlation with serum PFAS levels, with other food items also showing significant associations with the PFAS levels, such as fish, cereals and fruit juice. Fish oil consumption, which is not associated with PFAS exposure 34 , increases serum levels of phospholipids and PUFA-containing TGs 35 . Conversely, PFAS exposure is associated with increased levels of these lipids 36 .…”

Section: Metabolic Profiles In Mothers Associate With Pfas Exposurementioning

confidence: 98%

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

McGlinchey

Sinioja

Lamichhane

et al. 2019

Preprint

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In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid-related and immune markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association was exacerbated by increased human leukocyte antigenconferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.3

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“…PFASs, on the other hand, are a group of man-made chemicals that have been widely used since the 1950s in both household and industrial products. PFASs also have long biological half-lives, and are readily detected in humans [3][4][5][6][7]. Structurally, several PFAS compounds resemble endogenous fatty acids, with fluorine substitution in place of hydrogen.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography–tandem mass spectrometry

et al. 2019

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There is evidence of a positive association between per-and polyfluoroalkyl substances (PFASs) and cholesterol levels in human plasma, which may be due to common reabsorption of PFASs and bile acids (BAs) in the gut. Here we report development and validation of a method that allows simultaneous, quantitative determination of PFASs and BAs in plasma, using 150 μL or 20 μL of sample. The method involves protein precipitation using 96-well plates. The instrumental analysis was performed with ultraperformance liquid chromatography-tandem mass spectrometry (UHPLC-MS), using reverse-phase chromatography, with the ion source operated in negative electrospray mode. The mass spectrometry analysis was carried out using multiple reaction monitoring mode. The method proved to be sensitive, robust, and with sufficient linear range to allow reliable determination of both PFASs and BAs. The method detection limits were between 0.01 and 0.06 ng mL −1 for PFASs and between 0.002 and 0.152 ng mL −1 for BAs, with the exception of glycochenodeoxycholic acid (0.56 ng mL −1). The PFAS measured showed excellent agreement with certified plasma PFAS concentrations in NIST SRM 1957 reference serum. The method was tested on serum samples from 20 healthy individuals. In this proof-of-concept study, we identified significant associations between plasma PFAS and BA levels, which suggests that PFAS may alter the synthesis and/or uptake of BAs.

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Perfluoroalkyl substances in adolescents in northern Norway: Lifestyle and dietary predictors. The Tromsø study, Fit Futures 1

Cited by 57 publications

References 59 publications

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography–tandem mass spectrometry

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