Perfluoroalkyl acids (PFAAs) in indoor and outdoor dusts around a mega fluorochemical industrial park in China: Implications for human exposure

Su, Hongqiao; Lü, Yonglong; Wang, Pei; Shi, Yunfeng; Li, Qifeng; Zhou, Yunqiao; Johnson, Andrew C.

doi:10.1016/j.envint.2016.07.002

Cited by 70 publications

(25 citation statements)

References 40 publications

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“…This would be expected on the basis of the prevailing wind in the area(Barton et al, 2006). PFAAs levels in house and street dust around the FIP mainly from dry deposition followed a similar trend(Su et al, 2016).…”

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confidence: 54%

Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China

Liu

Lü

Shi

et al. 2017

Environment International

Self Cite

127

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Significant quantities of perfluoroalkyl acids (PFAAs) are released to the environment from fluorochemical manufacturing processes through wastewater discharge and air emission in China, which may lead to human exposure and health risks through crop bioaccumulation from PFAAs-contaminated soil and irrigation water. This paper systematically studied the distribution and transport of PFAAs in agricultural soil, irrigation water and precipitation, followed by crop bioaccumulation and finally human exposure of PFAAs within a 10km radius around a mega-fluorochemical industrial park (FIP). Hotspots of contamination by PFAAs were found near the FIP and downstream of the effluent discharge point with the maximum concentrations of 641ng/g in agricultural soil, 480ng/g in wheat grain, 58.8ng/g in maize grain and 4,862ng/L in precipitation. As the distance increased from the FIP, PFAAs concentrations in all media showed a sharp initial decrease followed by a moderate decline. Elevated PFAA concentrations in soil and grains were still present within a radius of 10 km of the FIP. The soil contamination was associated with the presence of PFAAs in irrigation water and precipitation, and perfluorooctanoic acid (PFOA) was the dominant PFAA component in soil. However, due to bioaccumulation preference, short-chain perfluoroalkyl carboxylic acids (PFCAs), especially perfluorobutanoic acid (PFBA), became the major PFAA contaminants in grains of wheat and maize. The bioaccumulation factors (BAFs) for both grains showed a decrease with increasing chain length of PFAAs (approximately 0.5 log decrease per CF group). Compared to maize grain, wheat grain showed higher BAFs, possibly related to its higher protein content. The PFCA (C4-C8) concentrations (on a log basis) in agricultural soil and grain were found to show a linear positive correlation. Local human exposure of PFOA via the consumption of contaminated grains represents a health risk for local residents, especially for toddlers and children.

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confidence: 54%

Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China

Liu

Lü

Shi

et al. 2017

Environment International

Self Cite

127

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“…PFOA and PFOS are detectable in outdoor air near manufacturing facilities. 66 , 67 However, they have also been detected more ubiquitously in house dust globally. 68 – 70 …”

Section: Sources Of Exposure To Edcs In Airmentioning

confidence: 99%

Overview of air pollution and endocrine disorders

Darbre¹

2018

IJGM

169

111

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Over recent years, many environmental pollutant chemicals have been shown to possess the ability to interfere in the functioning of the endocrine system and have been termed endocrine disrupting chemicals (EDCs). These compounds exist in air as volatile or semi-volatile compounds in the gas phase or attached to particulate matter. They include components of plastics (phthalates, bisphenol A), components of consumer goods (parabens, triclosan, alkylphenols, fragrance compounds, organobromine flame retardants, fluorosurfactants), industrial chemicals (polychlorinated biphenyls), products of combustion (polychlorinated dibenzodioxins/furans, polyaromatic hydrocarbons), pesticides, herbicides, and some metals. This review summarizes current knowledge concerning the sources of EDCs in air, measurements of levels of EDCs in air, and the potential for adverse effects of EDCs in air on human endocrine health.

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“…PFAAs have long biological half‐life; in humans, the serum half‐lives of perfluorooctanoic acids (PFOA), perfluorooctanesulphonate (PFOS) and of perfluorohexanesulphonate are reported to be 3.8, 5.4 and 8.5 years, respectively (Olsen et al, ). Human exposure to PFAAs occurs mainly through dust, food, drinking water and inhalation of PFAAs‐contaminated air (Su et al, ). Because of increasing environmental contamination and bioaccumulation of PFAAs, serious scientific and regulatory concerns have been raised regarding their potential risk to humans and wildlife.…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice

Singh

2018

J of Applied Toxicology

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Perfluoroalkyl acids (PFAAs) are widely used in commercial applications and that they are ubiquitous and persistent in the environment. Perfluorononanoic acid (PFNA), a member of PFAAs, has been detected in human and wildlife. Previous acute exposure studies have shown the adverse effect of PFNA on the testis. The present study was aimed to examine the effect of chronic PFNA exposure, from prepuberty to adulthood, on testicular functions and fertility in Parkes (P) male mice and to investigate the possible mechanism(s) of its action. PFNA (0.2 and 0.5 mg/kg) was orally administered to P male mice for 90 days from prepuberty (postnatal day [PND] 25) to adulthood (PND 114). Histologically, testes in PFNA‐treated mice showed non‐uniform degenerative changes in the seminiferous tubules. The treatment also had adverse effects on testicular expression of steroidogenic markers, serum levels of cholesterol and testosterone, sperm parameters and on litter size. A marked increase in the level of lipid peroxidation and decrease in the activities of antioxidant enzymes were observed in the testis of PFNA‐treated mice compared to controls. Further, a significant decrease in expression of proliferating cell nuclear antigen (PCNA) and in the number of PCNA‐positive cells, and an increase in expression of caspase‐3 were also noted in PFNA‐treated mice testis. In conclusion, the results suggest that chronic exposure to PFNA in male mice interferes with testosterone biosynthesis and causes oxidative stress in the testis, leading to alterations in spermatogenesis, sperm quality and fertility potential.

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Perfluoroalkyl acids (PFAAs) in indoor and outdoor dusts around a mega fluorochemical industrial park in China: Implications for human exposure

Cited by 70 publications

References 40 publications

Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China

Crop bioaccumulation and human exposure of perfluoroalkyl acids through multi-media transport from a mega fluorochemical industrial park, China

Overview of air pollution and endocrine disorders

Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice

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