Perfluoro-N-Octane as a Postoperative Vitreoretinal Tamponade in the Management of Giant Retinal Tears

Abstract

Postoperative tamponade with perfluoro-n-octane may decrease the rate of redetachment in giant retinal tear repair compared with silicone oil or perfluorocarbon gas alone. We found no adverse effects directly attributable to perfluoro-n-octane.

Pars Plana Vitrectomy With Medium-Term Postoperative Perfluoro-N-Octane for Recurrent Inferior Retinal Detachment Complicated by Advanced Proliferative Vitreoretinopathy

“…15,28 We observed a high rate (32%) of a characteristic inflammation compared with some previous clinical studies using postoperative PFO for RD. [22][23][24] This may be because of the longer average duration of PFO used in the present study, or underrecognition and retrospective design of previous studies. Rush et al 22 have recently observed inflammation with posterior lens capsule deposits in a comparable proportion (8/39) of eyes with postoperative PFO and reported similar resolution after PFO removal and clinical management with topical corticosteroids.…”

“…Previous reports have indicated mixed results using heavier-than-water compounds, and previous series investigating PFO 11,[22][23][24]27 have reported small samples of patients with PVR. The results of the present study indicate that a high rate of anatomical success can be achieved with short duration postoperative PFO in advanced PVR.…”

“…Recently, several reports have indicated that PFO may be left in the vitreous cavity postoperatively for short durations and may be useful for inferior retinal tamponade. [22][23][24] The purpose of the present study was to describe a technique involving PPV, intermediate (2-to 3-week duration) "medium-term" postoperative PFO (MT-PFO) followed by staged PFO removal in patients presenting with inferior retina redetachment complicated by Grade C PVR.…”

Efficacy of Short-term Postoperative Perfluoro-n-octane Tamponade for Pediatric Complex Retinal Detachment

“…Thus far, postoperative perfluoro-n-octane short-term tamponade has been used mainly for retinal detachments caused by giant tears. [5][6][7] Sirimaharaj and associates 6 reported that perfluoro-n-octane was effective for short-term postoperative tamponade to manage retinal detachments resulting from giant retinal tears. They elected to leave the perfluoro-n-octane in situ for 5 to 14 days because doing so provided sufficient time for chorioretinal adhesions to develop.…”

The concept of heavy tamponades—chances and limitations

“…Despite the aforementioned concerns about retinal toxicity, this role has been successfully extended to shortterm postoperative tamponade, with reduced re-detachment rates [35,39]. Here HSO could eventually reduce PVR rates compared to standard silicone oils; however, randomized controlled trials are required to finally solve this question.…”