Perfluorinated Compounds in Relation to Birth Weight in the Norwegian Mother and Child Cohort Study

Whitworth, Kristina W.; Haug, Line Småstuen; Baird, Donna D.; Becher, Georg; Hoppin, Jane A.; Skjærven, Rolv; Thomsen, Cathrine; Eggesbø, Merete; Travlos, Gregory S.; Wilson, Ralph E.; Cupul-Uicab, Lea A.; Brantsæter, Anne Lise; Longnecker, Matthew P.

doi:10.1093/aje/kwr459

Cited by 101 publications

(88 citation statements)

References 47 publications

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“…Epidemiologic research, which exists primarily as cross-sectional studies, on the possible effects on female reproductive health has so far produced inconsistent results. Fei et al (2009) observed an association between high serum levels of PFOS and PFOA and a longer time to pregnancy, but no such association was found in other studies (Vestergaard et al, 2012;Whitworth et al, 2012). PFOS and PFOA pass through the placenta (Needham et al, 2011) and are excreted in milk, although less so than other POPs (Haug et al, 2011;Mannetje et al, 2012).…”

Section: Introductionmentioning

confidence: 93%

Current exposure of Italian women of reproductive age to PFOS and PFOA: A human biomonitoring study

Felip

Abballe

Albano³

et al. 2015

Chemosphere

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Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) concentrations were determined in serum samples collected in 2011-2012 from 549 nulliparous Italian women of reproductive age who resided in six different Italian Regions. Assessment of exposure to perfluorinated compounds was part of a large human biomonitoring study (Project Life Plus "Womenbiopop") that aimed at examining the exposure of women of reproductive age to priority organic pollutants. The median concentrations of PFOS and PFOA were 2.43, and 1.55 ng g(-1), respectively. Significant differences in the concentrations of both compounds were observed among the six Regions. Women from central Italy had the highest levels of both compounds, followed by women from northern Italy, and southern Italy. No differences in the PFOS concentrations were found between women from urban/industrial areas and women from rural areas, whereas the levels of PFOA were significantly higher in women residing in urban/industrial areas than in women residing in rural areas. Taken together, the observed concentrations confirm that the overall exposure of the Italian population is among the lowest observed in industrialized countries. A downward temporal trend in exposure was observed for both compounds when comparing the results from the present study with those assessed in a study conducted in 2008.

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Section: Introductionmentioning

confidence: 93%

Current exposure of Italian women of reproductive age to PFOS and PFOA: A human biomonitoring study

Felip

Abballe

Albano³

et al. 2015

Chemosphere

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“…Perinatal exposure to a variety of environmental toxins has been associated with low birth weight, including phthalates [50], perfluorinated compounds [51][52][53] and occupational exposures to pesticides [54]. Furthermore, there appear to be relationships of environmental toxins with birth at lower gestational age, and phthalates [55,56] and perfluorinated compounds [51,53] with preterm birth.…”

Section: -29 ≥30mentioning

confidence: 99%

“…Furthermore, there appear to be relationships of environmental toxins with birth at lower gestational age, and phthalates [55,56] and perfluorinated compounds [51,53] with preterm birth.…”

Section: -29 ≥30mentioning

confidence: 99%

Early-life risk factors for chronic nonrespiratory diseases

et al. 2014

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We have witnessed a change in disease patterns contributing to the global burden of disease, with a shift from early childhood deaths due to the classic infectious communicable diseases to years lived with disability from chronic noncommunicable diseases. In both developing and developed countries, the years lived with disability attributable to chronic disease have increased: cardiovascular diseases by 17.7%; chronic respiratory disease by 8.5%; neurological conditions by 12.2%; diabetes by 30.0%; and mental and behavioural disorders by 5.0% over the past 20 years. Recognition of the contribution made by adverse environmental exposures in early life to noncommunicable diseases in later life is increasing. These earlylife exposures appear to contribute to both chronic respiratory and chronic nonrespiratory diseases. In this State of the Art article, we aim to examine early-life environmental exposures that have an epidemiological association with chronic nonrespiratory diseases, such as obesity and type II diabetes, cardiovascular disease, and neurocognitive and behavioural problems. We will highlight the potential overlap in environmental risks with respiratory diseases, and point out knowledge gaps and research opportunities. @ERSpublications Respiratory diseases are linked to obesity/diabetes/metabolic syndrome, CVD and neurocognitive/behavioural disorders

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“…Also another study from the US (n = 293) reported levels of cord blood PFOA (and PFOS) to be inversely associated with birth weight, new-born head circumference, crown-heel length, and ponderal index (Apelberg et al, 2007). Data from a subgroup of the Norwegian Mother and Child Cohort study (n = 901 women; 2003-2004) showed lower birth weight among infants born to mothers in the highest quartiles of PFOA (and PFOS) compared to lowest quartiles (Whitworth et al, 2012a). Also a British study found that girls born to mothers with maternal serum concentrations of PFOA in the upper tertile weighed less (130 g (95%CI: -237, -30)) at birth compared with girls born to mothers with serum concentrations in the lower tertile (Maisonet et al, 2012).…”

Section:  Developmental Outcomementioning

confidence: 99%