Perfluorinated chemicals in blood serum of inhabitants in central Poland in relation to gender and age

Góralczyk, Katarzyna; Pachocki, Krzysztof A; Hernik, Agnieszka; Struciński, Paweł; Czaja, Katarzyna; Lindh, Christian; Jönsson, Bo; Lenters, Virissa; Korcz, Wojciech; Minorczyk, Maria; Matuszak, Małgorzata; Ludwicki, Jan K

doi:10.1016/j.scitotenv.2015.06.050

Cited by 47 publications

(24 citation statements)

References 53 publications

(66 reference statements)

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“…The increased use of PFUnDA is accompanied by an increased PFUnDA serum level, with an increase (8%) in human sera in Northern Norway between 2001 and 2007 [46] . Typical mean human serum levels reported for PFUnDA are 0.1–0.4 ng/ml and maximal levels 0.70–1.4 ng/ml, compared to 11–23 ng/ml and 3–9 ng/ml for maximal PFOS and PFOA serum levels respectively [11] , [25] , [36] , [46] , [52] , [58] , [62] .…”

Section: Introductionmentioning

confidence: 93%

Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes

et al. 2016

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Perfluoralkylated substances (PFAS) are classified as persistent, bioaccumulative and toxic substances and are widespread environmental contaminants. Humans are exposed through food, drinking water and air. We have previously reported that bisphenol A accelerates spontaneous diabetes development in non-obese diabetic (NOD) mice and observed in the present study that perfluoroundecanoic acid, PFUnDA, increased insulitis development, a prerequisite for diabetes development in NOD mice. We exposed NOD mice to PFUnDA in drinking water (3, 30 and 300 μg/l) at mating, during gestation and lactation and until 30 weeks of age. After 300 μg/l PFUnDA exposure, we report (i) increased pancreatic insulitis, (ii) increased number of apoptotic cells in pancreatic islets prior to insulitis and (iii) decreased phagocytosis in peritoneal macrophages. There was also a trend of decreased number of tissue resident macrophages in pancreatic islets prior to insulitis after exposure to 300 μg/l, and altered cytokine secretion in activated splenocytes after exposure to 3 μg/l PFUnDA. Although insulitis is a prerequisite for autoimmune diabetes, the accelerated insulitis was not associated with accelerated diabetes development. Instead, the incidence of diabetes tended to be reduced in the animals exposed to 3 and 30 μg/l PFUnDA, suggesting a non-monotonic dose response. The effects of PFUnDA exposure on increased apoptosis in pancreas and reduced macrophage function as well as accelerated insulitis development in NOD mice, may also be relevant for human insulitis. Further observational autoimmune diabetes clinical cohort studies and animal experiments for PFUnDA as well as other PFASs are therefore encouraged.

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Section: Introductionmentioning

confidence: 93%

Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes

et al. 2016

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“…Varieties of PFAAs have been detected in human blood (both in serum and plasma) [5,39,148,[156][157][158] as well as in umbilical cord [38,159] and maternal [160,161] blood. Besides blood, some PFAAs have also been found in other human tissues.…”

Section: Toxicological Studies Of Pfaasmentioning

confidence: 99%

“…Biomonitoring of perfluoroalkyl substances in the human body started in 2000. Many PFAAs have been detected in human matrices, most commonly in blood samples [4,5]. In recent years, a number of papers have confirmed the occurrence of these compounds in breast milk [6], seminal plasma [7], umbilical cord blood [8], and liver [9].…”

Section: Introduction and Objectivesmentioning

confidence: 99%

A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination

Sznajder‐Katarzyńska

Surma

Cieślik

2019

Journal of Chemistry

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Per- and polyfluoroalkyl substances (PFASs) are widely distributed across the world and are expected to be of concern to human health and the environment. The review focuses on perfluoroalkyl acids (PFAAs) and, in particular, on the most frequently discussed perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonic acids (PFSAs). In this study, some basic information concerning PFASs is reviewed, focusing mainly on PFAAs (perfluoroalkyl acids). We have made efforts to systemize their division into groups according to chemical structure, describe their basic physicochemical properties, characterize production technologies, and determine potential human exposure routes with particular reference to oral exposure. A variety of possible toxicological effects to human health are also discussed. In response to increasing public concern about the toxicity of PFAAs, an evaluation of dietary intake has been undertaken for two of the most commonly known PFAAs: perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). As summarized in this study, PFAAs levels need further assessment due to the science-based TWI standards laid down by the EFSA’s CONTAM Panel regarding the risk to human health posed by the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food (tolerable weekly intakes of PFOA and PFOS set up to 6 ng·kg−1·bw·week−1 and 13 ng·kg−1·bw·week−1, respectively). Current legislation, relevant legislation on PFAAs levels in food, and the most popular methods of analysis in food matrices are described.

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“…In this case, scientists have no clear opinion on the order of emergence of these diseases, i.e. whether obesity causes the appearance of a coexisting disease -diabetes or vice versa (EFSA, 2012;Góralczyk et al, 2015b;Hoyer et al, 2014;WHO, 2012a).…”

Section: Characteristics and The Effects Of Chosen Environmental Pollmentioning

confidence: 99%

Are the civilization diseases the result of organohalogen environmental pollution?

Góralczyk

Majcher

2019

Acta Biochim Pol

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The notion of ‘civilization diseases’ is used to describe certain ailments whose aetiology is difficult to explain based on the knowledge about the functioning of the body and its metabolism. Only studies at the cellular level, on biochemical changes shed light on the causes of some diseases described as civilization diseases (cancers, cardiovascular and respiratory diseases, obesity, psychomotor disorders in children and an increase in the frequency of malformations). The factors whose incontestable influence on the increase in the frequency of occurrence of various ‘civilization diseases’ has been proved are persistent organic pollutants, among others belonging to the group of organohalogen compounds. Among organohalogen pollutants one needs to distinguish organochlorine compounds, which have been used as pesticides, and pollution emitted by various industries such as dioxins and furans, polychlorinated biphenyls, and polybrominated organic compounds used as flame retardants and perfluoroalkylated substances, which are characterized by high chemical and thermal stability as well as high surface activity due to which they may be widely used as oleophobic and hydrophobic factors.

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Perfluorinated chemicals in blood serum of inhabitants in central Poland in relation to gender and age

Cited by 47 publications

References 53 publications

Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes

Exposure to perfluoroundecanoic acid (PFUnDA) accelerates insulitis development in a mouse model of type 1 diabetes

A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination

Are the civilization diseases the result of organohalogen environmental pollution?

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