Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health

Stanifer, John W.; Stapleton, Heather M.; Souma, Tomokazu; Wittmer, Ashley; Zhao, Xinlu; Boulware, L. Ebony

doi:10.2215/cjn.04670418

Cited by 150 publications

(81 citation statements)

References 89 publications

(129 reference statements)

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“…However, PFASs are considered as the global pollutants since they contain numerous manufactured nonbiodegradable compounds. In addition, an increasing body of evidence points to PFASs as environmental threat to kidney function [25][26]. Thus, the surface modification using PFASs is not an eco-friendly approach to produce super-hydrophobic surfaces.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of super-hydrophobic nickel film on copper substrate with improved corrosion inhibition by electrodeposition process

Yang

Liu

Tian

2019

Colloids and Surfaces A: Physicochemical and Engineering Aspect

111

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Section: Introductionmentioning

confidence: 99%

Fabrication of super-hydrophobic nickel film on copper substrate with improved corrosion inhibition by electrodeposition process

Yang

Liu

Tian

2019

Colloids and Surfaces A: Physicochemical and Engineering Aspect

111

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“…PFOA also induces oxidative stress in a dose-dependent manner from 0.5 to 5 mg/kg/day in the mouse liver and pancreas [25], and a variety of tissues including rat pancreatic β-cells [92], mouse testes and epididymis [93], and mouse ovary [94]. Similarly, in vivo and in vitro studies have demonstrated that PFOS exposure results in oxidative stress, evidenced by the production of ROS, changes in antioxidant enzymes, elevation of lipid peroxidation products and changes in Nrf2 [32,[95][96][97]. Increased lipid peroxidation and antioxidant enzyme activity were also observed in mouse testes following PFNA exposure [98].…”

Section: Induces Oxidative Stressmentioning

confidence: 99%

“…Human epidemiologic studies have linked occupational, community, and general population exposure to PFOS and PFOA with an elevated risk of cancer. Prior reviews have focused on all cancers [19,30], and on breast [31] and kidney cancer [32]. A study of occupationally exposed workers reported a 3.3-fold increase in prostate cancer mortality for each month spent in the chemical division of PFOA production [33], although a re-analysis of this cohort did not detect an association between exposure and cancer mortality or incidence [34].…”

Section: Existing Research On Pfas Exposure and Cancer Riskmentioning

confidence: 99%

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Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

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“…Most interestingly, PFCAs are mainly accumulated in plasma, liver, and kidney due to their protein affinity [10,11]. In recent years, many studies have been conducted to assess the potential impact of PFOA on human health [7,[12][13][14]. However, owing to the lack of toxicological data for other PFCAs, the risk assessment of environmental pollution caused by PFCAs is still very limited.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Interaction Mechanism of Perfluoroalkyl Carboxylic Acids with Human Serum Albumin by Spectroscopic Methods

Chen¹,

Wang²,

Cai³

et al. 2020

IJERPH

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Perfluoroalkyl carboxylic acids (PFCAs) are some of the most significant pollutants in human serum, and are reported to be potentially toxic to humans. In this study, the binding mechanism of PFCAs with different carbon lengths to human serum albumin (HSA) was studied at the molecular level by means of fluorescence spectroscopy under simulated physiological conditions and molecular modeling. Fluorescence data indicate that PFCAs with a longer carbon chain have a stronger fluorescence quenching ability. Perfluorobutanoic acid (PFBA) and perfluorohexanoic acid (PFHxA) had little effect on HSA. Fluorescence quenching of HSA by perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) was a static process that formed a PFCA–HSA complex. Electrostatic interactions were the main intermolecular forces between PFOA and HSA, while hydrogen bonding and van der Waals interactions played important roles in the combination of PFDA and HSA. In fact, the binding of PFDA to HSA was stronger than that of PFOA as supported by fluorescence quenching and molecular docking. In addition, infrared spectroscopy demonstrated that the binding of PFOA/PFDA resulted in a sharp decrease in the β-sheet and α-helix conformations of HSA. Our results indicated that the carbon chain length of PFCAs had a great impact on its binding affinity, and that PFCAs with longer carbon chains bound more strongly.

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Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health

Abstract: A growing body of evidence portends PFASs are emerging environmental threats to kidney health; yet several important gaps in our understanding still exist.

Cited by 150 publications

References 89 publications

Fabrication of super-hydrophobic nickel film on copper substrate with improved corrosion inhibition by electrodeposition process

Fabrication of super-hydrophobic nickel film on copper substrate with improved corrosion inhibition by electrodeposition process

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Investigation of the Interaction Mechanism of Perfluoroalkyl Carboxylic Acids with Human Serum Albumin by Spectroscopic Methods

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