Perfluor-Verbindungen als Blutersatzmittel

Riess, Jean G.; Blanc, Maurice

doi:10.1002/ange.19780900905

Cited by 35 publications

(10 citation statements)

References 63 publications

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“…Perfluoroalkanes have found very useful applications, for instance as blood substitutes. 91 Fluorine-containing organotin compounds 92±96 are a possible way to solve the water-solubility problem encountered with almost all the organotin compounds described in the preceding paragraphs. The results were quite encouraging.…”

mentioning

confidence: 99%

Review: Organotin compounds and their therapeutic potential: a report from the Organometallic Chemistry Department of the Free University of Brussels

Gielen¹

2002

Applied Organom Chemis

506

263

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An overview of the development of antitumour organotin derivatives is presented and discussed for selected classes of compounds, such as tetraorganodicarboxylatodistannoxanes and related diorganotin dicarboxylates, and for triorganotin carboxylates. Among the carboxylate groups used are steroidcarboxylates and other biologically relevant carboxylates. High to very high in vitro activities have been found, sometimes equalling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds. Polar substituents, like fluorine or polyoxaalkyl moieties, improve the water solubility. Although organotin derivatives constitute a separate class of compounds, the comparison with cisplatin is inevitable. Among the observed toxicities, neurotoxicity, known from platinum cytostatics, and gastrointestinal toxicity, typical for many oncology drugs, have been detected, but to a lower extent. Further research to develop novel useful organotin antitumour compounds needs to be carried out.

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confidence: 99%

Review: Organotin compounds and their therapeutic potential: a report from the Organometallic Chemistry Department of the Free University of Brussels

Gielen¹

2002

Applied Organom Chemis

506

263

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“…Since the O 2 solubility in fluorinated solvents is 3 to 10 times greater than in benzene [14], the loss of the nitroxide EPR signal was investigated in an O 2 -saturated fluorinated solvent. For this purpose, perfluoro(2-butyltetrahydrofuran) (PFTF) was chosen because it can dissolve O 2 gas up to a concentration of 21.3 mM at 295 K [15]. Fig.…”

mentioning

confidence: 99%

Interaction between Molecular Oxygen and Nitroxide Radicals: A Search for a Reversible Complex

Moscatelli

Ottaviani

Adam

et al. 2006

Helvetica Chimica Acta

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Dedicated to the memory of Professor Hanns FischerAt high concentrations of oxygen, the EPR spectrum of the nitroxide radical 4-oxo-TEMPO (= 4-oxo-2,2,6,6-tetramethylpiperidin-1-yloxy) is found to broaden significantly. In addition to the expected broadening, double integration of the EPR signals indicates that a significant fraction of the nitroxide spins has disappeared. In perfluoro(2-butyltetrahydrofuran) at 273 K, the extent of diminution of the EPR signal intensity is ca. 20%. The results are analyzed in terms of collision and supramolecular complexes between oxygen and 4-oxo-TEMPO. It is concluded that a supramolecular complex is responsible for the observed phenomenon.

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“…Extension to mixtures is straightforward by introducing conventional combining rules. 157 When relinquishing the universal values for H a and fl b we obtain for instance ( 7 6 ) Here, V is the molar volume calculated from Equation 69 with mixture parameters a and b from Equations 72 and 73, and parameters fi aJ and fi bi are permitted to vary somewhat from one substance to another; optimized values have been reported by Chueh and Prausnitz, 157 together with estimates for binary interaction parameters k, } of Equation 58.…”

Section: Lthe Vapor Phasementioning

confidence: 96%

“…Extension to mixtures follows closely Reference 147, that is to say C ijk = (CyCfcCjJ" 3 (66) and the C i} , etc. are evaluated via Equation 64 with T c being replaced by T c-ij (see Equation 58), V c by V c y (see Equation 60), and…”

Section: Lthe Vapor Phasementioning

confidence: 99%

Precision Methods for the Determination of the Solubility of Gases in Liquids

Wilhelm¹,

Battino²

1985

C R C Critical Reviews in Analytical Chemistry

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Perfluor-Verbindungen als Blutersatzmittel

Abstract: derzeit ausreichend beherrscht werden und daD dies in Anbetracht der intensiven Forschungsarbeiten iiber Sicherheitsfragen auch fur den weiteren Ausbau der Kernenergie gelte". ,,Die verbleibenden Restrisiken werden", so heifit es in dem offenen Brief, ,,von

Cited by 35 publications

References 63 publications

Review: Organotin compounds and their therapeutic potential: a report from the Organometallic Chemistry Department of the Free University of Brussels

Review: Organotin compounds and their therapeutic potential: a report from the Organometallic Chemistry Department of the Free University of Brussels

Interaction between Molecular Oxygen and Nitroxide Radicals: A Search for a Reversible Complex

Precision Methods for the Determination of the Solubility of Gases in Liquids

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