It was verified the association between oral health, quality of life and associated factors in a population in a southern Brazilian city. Cross-sectional study with 373 dwellers of the Ferraria District, Campo Largo, PR, Brazil, that answered a questionnaire with sociodemographic, socioeconomic, quality of life, habits, general and oral health, and Oral Health Impact Profile (OHIP-14) variables. Statistical analysis was performed in a univariate and multivariate way (significance level of 5%). In the univariate analysis, 47.7% of individuals had OHIP-14> 12. Worse impacts were reported by olders, women, non-white, divorced or widowed, with lower education and income, worse self-classification of quality of life and general health, depressive, with worse neighborhood conditions, who brush their teeth less and with more need for dental treatment. In the multivariate analysis, olders, female, non-white, presnce of caries or gingival problems and poor self-classification of quality of life reported worse impacts. The worst impacts was associated with sociodemographic, socioeconomic, psychosocial and behavioral variables, which indicates the need for actions to improve several aspects of the population of the Ferraria District.