PERFIL METABÓLICO DOS EXTRATOS POLARES DAS FOLHAS, GALHOS E CASCAS DE Copaifera multijuga HAYNE (COPAÍBA MARI-MARI DA AMAZÔNIA) POR ESI-EM

UHPLC-HRMS/MS on untargeted metabolomics: a case study with Copaifera (Fabaceae)

“…Previous description of condensed tannins with copaiba were only within the barks of C. multijuga . 15,26 The presence of compounds 13 with C. lucens and C. venezuelana gives preliminary evidences of their antioxidative activity and an antineoplastic effect against Ehrlich ascites carcinoma, since this diterpene have already being reported as one of the responsible metabolites for C. multijuga extracts bioactivity. 18 The occurrence of condensed tannins only in barks indicate such compounds as chemical markers of this organ within the genus and can be considerate to compose a set of chemical parameters to evaluate quality control of herbal products or even identification of the Copaifera genus.…”

“…Galloylquinic acids derivates had already been described within C. langsdorfii 23 and C. multijuga 15 polar extracts and are currently acknowledged as are remarkable gastroprotective and cytotoxic agents. 23 Recently, this chemical class had been indicated as characteristic compound on Copaifera leaves.…”

“…copalic acid and ent -agatic acid) chemical composition. 15 In addition to the oilresin, non-volatile extracts of copaiba twigs, branches, barks and trunk trees have several therapeutical applications in traditional medicine. However, copaíba extracts are not as famous as the oilresins, and present substantially few scientific exploitations.…”

Chemical variability of Copaifera langsdorffii Desf. from environmentally contrasting populations

“…The identification of galloylquinic acids derivatives was based on the fragmentation pattern of them, mainly characterized by the occurrence of m/z signals 523.1086, 357.0823, 339.0719, 191.0554 and 173.0445. The fragmentation spectra were compared to the data and discussion of Furtado et al 2015, Nogueira et al 2015, and Oliveira et al 2019. The fragmentation spectra obtained in this study can be observed next.…”

“…The identification of flavonoids was based on the data published by Oliveira et al 2019, andLiu et al 2016. The fragmentation spectra obtained in this study can be observed next.…”