Perfil etiológico das diarréias agudas de crianças atendidas em São Paulo

Souza, Eloísa Correa de; Martinez, Marina Baquerizo; Taddei, Carla R.; Mukai, Lilian; Gilio, Alfredo Elias; Rácz, Maria Lucia; Silva, Luzinete Alves; Ejzenberg, Bernardo; Okay, Yassuhiko

doi:10.1590/s0021-75572002000100008

Cited by 31 publications

(42 citation statements)

References 5 publications

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“…1,2 In developed countries, the commonest etiological agent is rotavirus, whereas in developing countries certain bacteria are the major causes. [3][4][5] Escherichia coli, mainly of the enteropathogenic strains, is the main bacterial cause identified in many studies of urban populations in developing countries. 1,4,6 The second commonest etiological agent isolated are Shigella spp., predominantly Shigella flexneri and Shigella sonnei.…”

Section: Introduction Dmentioning

confidence: 99%

“…[3][4][5] Escherichia coli, mainly of the enteropathogenic strains, is the main bacterial cause identified in many studies of urban populations in developing countries. 1,4,6 The second commonest etiological agent isolated are Shigella spp., predominantly Shigella flexneri and Shigella sonnei. 4,5 Salmonella sp., Campylobacter sp., and Yersinia sp.…”

Section: Introduction Dmentioning

confidence: 99%

“…1,4,6 The second commonest etiological agent isolated are Shigella spp., predominantly Shigella flexneri and Shigella sonnei. 4,5 Salmonella sp., Campylobacter sp., and Yersinia sp. are of less importance as bacterial causes of diarrhea, but they are isolated in some cases.…”

Section: Introduction Dmentioning

confidence: 99%

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Chemical and Antidiarrheal Studies ofPlinia cauliflora

Souza-Moreira

Severi

Santos

et al. 2011

Journal of Medicinal Food

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Plinia cauliflora (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determined the composition of fruit and leaf extracts of P. cauliflora, analyzed the activity against diarrhea by antimicrobial and gastrointestinal motility, and evaluated the cytotoxicity of the extracts. Chemical composition was determined by high-performance liquid chromatograpy-ultraviolet/photodiode array detection. Antimicrobial activity was analyzed by agar diffusion and the microdilution method against etiological agents of diarrhea. The effect on gastrointestinal motility was analyzed using an experimental model in mice. Cytotoxicity was evaluated in vitro with the fibroblast cell line SIRC CCL 60, and leaf extract showed a 50% inhibitory concentration of 0.48 lg/mL. Gallic acid, ellagic acid, and flavonoid derivatives were detected in the extracts. It was observed that fruit and leaf extracts showed some activity against Enterococcus faecalis, Escherichia coli, Salmonella sp., and Shigella sp. However, neither extract had any effect on gastrointestinal motility.

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Section: Introduction Dmentioning

confidence: 99%

Section: Introduction Dmentioning

confidence: 99%

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Chemical and Antidiarrheal Studies ofPlinia cauliflora

Souza-Moreira

Severi

Santos

et al. 2011

Journal of Medicinal Food

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“…No presente estudo, este patótipo foi detectado em 7,3% das amostras fecais diarréicas, concordando com a maioria dos estudos realizados no âmbito nacional (ALMEIDA et al, 1998;BUERIS et al, 2007;GOMES et al, 1991;SOUZA et al, 2002 É importante ressaltar que, neste estudo somente em uma única amostra diarréica foi detectada Salmonella spp., à diferença de estudos que mostram a presença deste microrganismo variando de 2,7% a 85% em fezes diarréicas de crianças, não sendo observado em fezes normais, sugerindo uma participação efetiva no desenvolvimento da diarréia aguda (MORENO et al, 2010;SPANO et al, 2008).…”

Section: Resultsunclassified

“…Esta observação verifica conjuntamente com os últimos estudos realizados no Brasil sobre a rara incidência deste enteropatógeno em diarréias de crianças menores de 5 anos de idade. Esta bactéria foi detectada por Souza et al (2002) em apenas uma amostra diarréica, sendo que estudos posteriores não detectaram sua presença em processos diarréicos (BARRETO et al, 2006;MORENO et al, 2010 …”

Section: Resultsunclassified

Avaliação quantitativa de enteropatógenos em crianças com e sem diarréia na cidade de São Paulo, SP.

Merino¹

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Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregativeEscherichia coli

Bellini

Elias

Gomes

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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Enteroaggregative Escherichia coli (EAEC) is an emerging cause of pediatric and adult travellers diarrhea. The mechanism by which EAEC induce diarrhea is not completely known. Two serine protease autotransporter proteins, named Pet and Pic have been identified in EAEC strains. Pet has enterotoxic and cytotoxic activities, while the role of Pic in pathogenesis may lie on its mucinolytic activity. Little is known about Pet and Pic biological activities in vivo. In this study the antibody responses against these autotransporter proteins in convalescent children is investigated. Fifteen (83%) children showed specific antibodies against Pet or Pic in their sera. IgG and IgM antibodies were the main isotype found. Specific antibodies against Pic, but not against Pet, were detected in sera from age-matched control group. These data show that specific anti-Pet and anti-Pic antibodies are produced during the course of a natural EAEC infection in children.

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Perfil etiológico das diarréias agudas de crianças atendidas em São Paulo

Cited by 31 publications

References 5 publications

Chemical and Antidiarrheal Studies ofPlinia cauliflora

Chemical and Antidiarrheal Studies ofPlinia cauliflora

Avaliação quantitativa de enteropatógenos em crianças com e sem diarréia na cidade de São Paulo, SP.

Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregativeEscherichia coli

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