Perfil de prescripción y adecuación del tratamiento con antiinflamatorios no esteroideos en el paciente diabético

Navarro-Martínez, A.; Vidal-Martínez, M.; García-Rosa, I.; Lázaro-Gómez, M.J.; Brotons-Román, J.

doi:10.1016/j.cali.2015.06.007

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Y aunque su abuso preocupa en diversos ámbitos sanitarios, las continuas investigaciones han descubierto nuevos usos, por ejemplo como parte del tratamiento para el acné debido a sus propiedades antiinflamatorias, además un estudio de la universidad de Harvard asegura que las personas que consumen regularmente ibuprofeno tienen un 38% menor riesgo de padecer Parkinson, así como su uso prolongado previene el Alzheimer. En enero de 2014 la Agencia Española de Medicamentos y Productos Sa-nitarios publicó un informe de utilización de AINE en España durante el periodo 2000-2012; siendo el Ibuprofeno el más utilizado, representando el 43,9% del consumo total de AINE (5).…”

Section: Indicacionesunclassified

Ibuprofeno: ¿fármaco seguro?

Barrios¹,

Correa²,

Gomendio³

et al. 2019

SALUD MIL

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Ibuprofen is a non-steroidal anti-inflammatory drug, with a long history of safety and effectiveness, used in the adult population both by medical indication and as self-medication as an over-the-counter drug. Various gastrointestinal, cardiovascular, renal adverse effects, among others, have been reported after its use, in many cases due to co-administration and interaction with other drugs, dose used, treatment duration or personal risk factors of the patient. Therefore, it is essential for the medical staff to teach the patient about avoiding self-medication, to know the patient's personal history and to indicate the minimum effective dose for the shortest time required, in order to avoid potential adverse effects. The present paper has the objective of analyzing, according to the available evidence, the safety of Ibuprofen at the level of the different organs and systems of the human body.

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Section: Indicacionesunclassified

Ibuprofeno: ¿fármaco seguro?

Barrios¹,

Correa²,

Gomendio³

et al. 2019

SALUD MIL

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Spectroscopic characterization and general features of piroxicam encapsulated in nanostructured lipid carriers

Otarola

Molina

Garrido

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Sildenafil attenuates nonsteroidal anti‐inflammatory‐induced gastric ulceration in mice via antioxidant and antigenotoxic mechanisms

Alves

Aires

Santos

et al. 2020

Clin Exp Pharma Physio

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Sildenafil (SIL) has potential as an interesting gastroprotective drug. However, the pathways of its protective effect still needs to be clarified, and its use as a potential gastroprotective agent validated. This study aims to evaluate the effects of SIL via modulation of oxidative stress in a NSAID‐induced gastric lesion model. Male Swiss mice were divided into six groups: control (CON, water), nonsteroidal anti‐inflammatory drug (NSAID, water), proton pump inhibitor (PPI, 30 mg/kg of lansoprazole), SIL 5 (5 mg/kg), SIL 25 (25 mg/kg) and SIL 50 (50 mg/kg). The animals were treated by gavage (a single dose) after 24 hours of fasting, and gastric lesions were performed after 30 minutes, with indomethacin (40 mg/kg, by gavage). After 6h, the animals were killed and the stomach was removed to evaluate reactive oxygen species (ROS) production, oxidation of macromolecules, quantification of antioxidant enzymes, DNA fragmentation, apoptosis and macroscopic and histologic analysis of gastric lesions. SIL exerts a dose‐dependent gastroprotective effect against NSAID‐induced mucosal injury, also reducing cytoplasmic levels of ROS and consequent oxidative damage to macromolecules. In addition, SIL increases nitric oxide bioavailability, antioxidant enzymes and gastric cellular viability, as well as restoring important factors involved in gastroprotection. Our results demonstrate that different doses of SIL prevent indomethacin‐induced gastric ulcer in mice via different, but complementary antioxidant, antigenotoxic and antiapoptotic mechanisms.

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Perfil de prescripción y adecuación del tratamiento con antiinflamatorios no esteroideos en el paciente diabético

Cited by 4 publications

References 22 publications

Ibuprofeno: ¿fármaco seguro?

Ibuprofeno: ¿fármaco seguro?

Spectroscopic characterization and general features of piroxicam encapsulated in nanostructured lipid carriers

Sildenafil attenuates nonsteroidal anti‐inflammatory‐induced gastric ulceration in mice via antioxidant and antigenotoxic mechanisms

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