Perfect space and time focusing ion optics for multiturn time of flight mass spectrometers

Ishihara, Morio; Toyoda, Michisato; Matsuo, T.

doi:10.1016/s1387-3806(99)00244-4

Cited by 40 publications

(30 citation statements)

References 7 publications

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“…Furthermore, for 100 attomol, a protein sequence coverage of 18% was obtained with 12 peptide fragments. The "perfect focusing" [12] nature of the ion optical system contributed to a 100 attomol level sensitivity; however, the ion beam was restricted by the beam-defining slit placed before the first level of TES1. …”

Section: Sensitivitymentioning

confidence: 99%

Development of a high-Performance MALDI-TOF mass spectrometer utilizing a spiral ion trajectory

Satoh

Sato

Tamura

2007

J. Am. Soc. Mass Spectrom.

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A novel MALDI-TOF mass spectrometer that utilizes a spiral ion trajectory was developed. In this mass spectrometer, the ions sequentially passed through four toroidal electrostatic sectors and revolved along a figure-eight-shaped orbit on a particular projection plane. Each toroidal electrostatic sector had eight stories, and during multiple revolutions, the ion trajectory shifted perpendicular to the projection plane in every cycle, thereby generating a spiral trajectory. The flight path length of one cycle was 2.1 m; therefore, when the ions completed eight cycles, the total flight path length was 17 m. By adopting an ion optical system that had a flight path length five times longer than that in the commonly used reflectron ion optical system, the mass dependence on the mass resolving power was reduced, while improving the mass accuracy of the mass measurements. The basic performance of the system was tested by using standard peptides or the tryptic digest of bovine serum albumin. A mass resolving power of 80,000 (full width at half maximum) was achieved at m/z = 2564 (ACTH18-39). An improved mass accuracy less than 2 ppm was realized over a wide m/z range of 500 to 3000 by correction using one or two internal standard substances.

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Section: Sensitivitymentioning

confidence: 99%

Development of a high-Performance MALDI-TOF mass spectrometer utilizing a spiral ion trajectory

Satoh

Sato

Tamura

2007

J. Am. Soc. Mass Spectrom.

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“…The mass spectrometer uses multi-turn and “perfect focusing” ion optics [25] to fit a very long (17-m) flight path into a compact space [26]. In TOF/TOF mode, an ion gate positioned at the 15 m point in the spiral ion flight path is used to isolate and guide the precursor ion into a gas-filled collision chamber.…”

Section: Introductionmentioning

confidence: 99%

Structural Analysis of Triacylglycerols by Using a MALDI-TOF/TOF System with Monoisotopic Precursor Selection

Kubo

Satoh

Itoh

et al. 2012

J. Am. Soc. Mass Spectrom.

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A new MALDI-TOF/TOF system with monoisotopic precursor selection was applied to the analysis of triacylglycerols in an olive oil sample. Monoisotopic precursor selection made it possible to obtain product-ion mass spectra without interference from species that differed by a single double bond. Complete structure determination of all triacylglycerols, including structural isomers, was made possible by interpreting the charge-remote fragmentation resulting from high-energy collision-induced dissociation (CID) of the sodiated triacylglycerols.

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“…The 'perfect focusing' 9) condition is very important to increase the mass resolution for multi-turn systems. If it isn't satisfied, the ion beam will diverge.…”

Section: Ion Optics Of 'Multum Ii'mentioning

confidence: 99%

A Simple Multi-Turn Time of Flight Mass Spectrometer 'MULTUM II'

Okumura

Toyoda

Ishihara

et al. 2003

J. Mass Spectrom. Soc. Jpn.

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A new multi-turn time-of-flight mass spectrometer 'MULTUM II' was constructed. The ion optical system was simplified comparing with 'MULTUM Linear plus'. The multi-turn part of the new instruments consisted of only four toroidal electric sector fields. The mean radius of cylindrical electric sector was 50 mm and the deflection angle was 157.1ῐ. The total flight pass length of one cycle was 1.308 m. In a preliminary experiment, the mass spectra of Xe ion were measured and enhancement in mass resolution with increasing number of cycles was obserbed. The mass resolution 5100 at m/z 136 was achieved after 10 cycles. IntroductionThe theory of sector type of time-of-flight (TOF) mass spectrometers was proposed in 1970s by Poschenrieder. 1), 2) Triple focusing (directional focusing and vanishing energy-dependent dispersion in time-offlight and imaging) was satisfied by combining linear drift space with electric sector fields. In 1985, Sakurai et al. designed and constructed a multiple-focusing TOF mass spectrometer that satisfied triple isochronous focusing and triple space focusing simultaneously with four toroidal electric sector fields. 3)Moreover, Poschenrieder also proposed a multi-turn geometry resembling a figure 'eight'. Sakurai et al. designed and constructed a large multi-turn TOF mass spectrometer 'OVAL'.4) It consisted of six electrostatic analyzers. The length of the circular orbit was 7.4 m. A compact multi-turn TOF mass spectrometer 'MULTUM Linear plus' was developed in our laboratory. 5), 6) It consisted of four electric sectors and 28 Qlenses.The length of one cycle was 1.294 m. 'MULTUM Linear plus' was constructed as a laboratory model of the COSAC project of the ROSETTA mission. 7) However, it was not simple to carry on a spacecraft. In order to reduce weight of the instrument and simplify the instrument, we constructed 'MULTUM II' consisting of only four toroidal electric sector fields. In this paper, we report technical data for construction and preliminary experimental data. Ion Optics of 'MULTUM II'Detailed discussions about ion optics of a multi-turn TOF mass spectrometer were given elsewhere. 8), 9) Here we simply explain a feature of the ion optical system of 'MULTUM II'.The 'perfect focusing' 9) condition is very important to increase the mass resolution for multi-turn systems. If it isn't satisfied, the ion beam will diverge. Consequently the mass resolution and the ion transmission will decrease with increasing the number of cycles. To avoid this problem, absolute value of the position and angle at the final position should be the same as at the initial position in both the horizontal and vertical directions. This relationship is represented in a first order approximation by using transfer matrix method 10) as follows:where x, y, a, and b are the position and angle dispersion and g, d, l are the mass, energy and flight pass length deviation, respectively. The subscripts i and f indicate conditions of before and after a cycle, respectively. The ion optical system of 'MULTUM Linear plus' sa...

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Perfect space and time focusing ion optics for multiturn time of flight mass spectrometers

Cited by 40 publications

References 7 publications

Development of a high-Performance MALDI-TOF mass spectrometer utilizing a spiral ion trajectory

Development of a high-Performance MALDI-TOF mass spectrometer utilizing a spiral ion trajectory

Structural Analysis of Triacylglycerols by Using a MALDI-TOF/TOF System with Monoisotopic Precursor Selection

A Simple Multi-Turn Time of Flight Mass Spectrometer 'MULTUM II'

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