Percutaneous umbilical blood sampling in the management of kell isoimmunization

Ja, Copel; Scioscia, Angela L.; Pa, Grannum; Romero, Roberto; Ea, Reece; Jc, Hobbins

doi:10.1097/00006250-198602000-00025

Cited by 16 publications

(3 citation statements)

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“…Those antibodies react on Coombs test. The anti-Kell antibody is the most found after anti-D among irregular antibodies about 0.1 for Caine (1986) [13], 0.1 to 0.2% for Grant [14] and 0.16 to 0.21 for Queenan and Poleski on series of 18,378 and 43,000 patients [15]. In a Turkey series the first allo anti bodies were anti-E and anti-Kell [16].…”

Section: Discussionmentioning

confidence: 91%

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kalenga¹,

Nyembo²,

Mwange³

et al. 2017

JPP

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Introduction: The anti Kell is a major cause of hemolytic disease of the newborn; the third cause after ABO and Rhesus in frequency; and the second in terms of severity after rhesus type incompatibility. In Africa, 60% of the population is Kell negative. In Congo, Kell blood group determination is not systematically performed and almost non-existent in perinatology. We aimed to report a case of this immunization in routine practice. Method: This study is a clinical report of Kell immunization. Physical examination was performed and blood group determined. Clinical and biological follow up of the case: a review of the literature of Kell immunizations is included. Result: A female newborn on day 4 of life with weight of 3,250 g born at term admitted to Sendwe's Hospital emergency for pallor and respiratory distress. History reveals jaundice at birth. The mother is P1G4A3D0, blood group Orh+. Clinically the child is pale, jaundiced, present tachycardia, hepatomegaly, polypnea Brh+. The diagnostic orientation is a maternal-fetal incompatibility. The realization of blood grouping Kell, Duffy and irregular antibodies research Kell type confirms the diagnosis of Kell hemolytic disease of the newborn. We discharged him after 14 days. Conclusions: The Kell type IFME is a purveyor of grave hemolytic disease of the newborn. His knowledge, prevention and proper care by a multidisciplinary team can prevent dramatic situations.

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Section: Discussionmentioning

confidence: 91%

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kalenga¹,

Nyembo²,

Mwange³

et al. 2017

JPP

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“…Intrauterine transfusion is a life saving treatment in this condition 15,16 . Copel et al describe the use of, first, intraperitoneal, followed by intravascular transfusion in the management of a case of hydrops secondary to Kell alloimmunisation 16 .…”

Section: Discussionmentioning

confidence: 99%

The outcome of pregnancy in Kell alloimmunisation

Grant

Kilby

Meer

et al. 2000

BJOG

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Objective To assess management and outcome of pregnancies with anti-Kell in the West Midlands in Design A retrospective review of casenotes.Setting A regional referral clinic for red cell alloimmune disease and fetal medicine unit at a university hospital.Population Sixty-five pregnancies were identified in 52 Kell-sensitised women with Kell positive partners from the records of the Birmingham Blood Transfusion Centre.Methods Information from the casenotes was entered on a database and comparisons were made using the SPSS for Windows statistics package. Main outcome measuresMode of sensitisation, degree of fetal or neonatal anaemia, need for transfusion, gestation at delivery, birthweight and pregnancy outcome.Results Alloimmunisation was transfusion-related in 29 pregnancies and pregnancy-induced in 33. The cause could not be identified in three cases. There were 22 proven Kell positive fetuses, of which 18 were affected, in which alloimmunisation was pregnancy-related in 12 cases and transfusion-related in five. Antibody titres and amniotic fluid OD,,, were not helpful in management. Severe or very severe disease occurred in 50% of the affected pregnancies (9/18). There was no difference in pregnancy outcome between transfusion or pregnancy induced sensitisation.Conclusions Anti-Kell alloimmunisation is an uncommon cause of serious anaemia in a significant proportion of affected pregnancies. There appears to be no difference between that caused by pregnancy or transfusion. Estimation of fetal haemoglobin concentration by cordocentesis is recommended, as antibody titres and amniocentesis are not helpful.the UK over 13 years.

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“…7 It is possible to encounter women with titers as high as 512 with foetuses that are negative for the antigen to which the antibody is directed. 8…”

Section: Introductionmentioning

confidence: 99%

A Miracle Obstetrical Result: Iso-immunized Baby with HighTiter with Good Foetal Outcome

2015

Nepal j. obstet. gynaecol.

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We present a case of 26 years multigravid women (G2PoLoA1) with iso-immunized foetus with high titre 1:512, delivered at 36+6 weeks of pregnancy. She visited the hospital in the second trimester of pregnancy for routine antenatal check up. There was a past history of spontaneous abortion at 12 weeks where no immunoglobulin (rhogam) injection was taken. At 22+ weeks of gestation, she was admitted in the hospital with titre 1:128 and 1:512. Counseling was done for outcome of foetus and advised for termination, but parents wanted to continue the pregnancy. Dexamethasone injection was given for foetal lung maturity and then discharged. Baby was kept in the nursery and double phototherapy was given and discharged at the seventh day of life.

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Percutaneous umbilical blood sampling in the management of kell isoimmunization

Cited by 16 publications

References 0 publications

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

Kell Blood Group Maternal-Fetal Incompatibility in Lubumbashi (D. R. Congo), Case Report

The outcome of pregnancy in Kell alloimmunisation

A Miracle Obstetrical Result: Iso-immunized Baby with HighTiter with Good Foetal Outcome

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