Percutaneous treatment of aortic stenosis and mitral regurgitation in the same patient

Abstract

Transcatheter valve therapy is becoming an established treatment for aortic stenosis (AS) and it is very promising for mitral regurgitation (MR). There are no formal reports of percutaneous treatment of both AS and MR in the same patient. Here, we report on the first human cases of successful totally percutaneous management of combined severe AS and MR as a planned staged approach and using MitraClip(®) implantation as a procedure necessitated by an unpredictable complication of self-expanding CoreValve device, respectively.

Transcatheter Aortic Valve Replacement

“…Some (1,22), but not all (23), found increases in morbidity and mortality in patients with moderate MR. In contrast to surgical aortic valve replacement, concurrent mitral valve repair or replacement has not been an option in patients undergoing TAVR, although new transcatheter mitral therapies offer options in the future (24). Limited information is available with regard to the impact of MR on outcomes after TAVR.…”

5-Year Outcomes After Transcatheter Aortic Valve Implantation With CoreValve Prosthesis

“…However, the association between MR and the risk of rehospitalization due to heart failure has not been investigated yet. The results of this analysis tend to suggest that TAVI patients with significant pre-operative MR may potentially benefit from a staged invasive treatment of the mitral valvulopathy (i.e., transcatheter edge-to-edge technique), provided that they are anatomically suitable for that (21). However, the real clinical-and costeffectiveness of this strategy has to be carefully evaluated in future studies.…”

A systematic review of reported cases of combined transcatheter aortic and mitral valve interventions

“…A total of 1783 articles were screened and total of 37 studies met our inclusion/exclusion criteria. The details of study selection are summarized in Figure .…”