Percutaneous Transluminal Septal Myocardial Ablation in a Child with Hypertrophic Obstructive Cardiomyopathy and Noonan Syndrome

Singh, Harminder; Kalra, Ravi; Keshavamurthy, G; Singh, Maninder; Singh, Charanjit

doi:10.1111/j.1747-0803.2008.00179.x

Cited by 2 publications

(2 citation statements)

References 21 publications

(27 reference statements)

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“…Experience to date in children with alcohol septal ablation has been anecdotal. Several case reports have demonstrated its acute efficacy, although with a not insignificant risk of associated conduction system damage and recurrence of either symptoms or a gradient 72 73. The observed late increase in subaortic gradient may reflect the natural history of further myocardial hypertrophy in the growing child.…”

Section: Clinical Managementmentioning

confidence: 95%

Hypertrophic cardiomyopathy in children

Moak

Kaski

2012

Heart

100

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Hypertrophic cardiomyopathy (HCM) is the second commonest form of heart muscle disease affecting children and adolescents and is a leading cause of sudden death in young athletes. The aetiology of HCM is heterogeneous in the paediatric population, and includes inborn errors of metabolism, neuromuscular disorders and malformation syndromes. However, most cases of apparently idiopathic HCM in childhood are caused by mutations in cardiac sarcomere protein genes. Patients with metabolic or syndromic HCM usually present in infancy or early childhood, whereas those with neuromuscular disorders are more frequently diagnosed in adolescence. The diagnosis of HCM in infants is often made during evaluation for a heart murmur or congestive heart failure. Older children are usually referred for evaluation of symptoms, electrocardiographic abnormalities or heart murmur, or for family screening following the diagnosis of HCM in a relative. Risk stratification in the paediatric population remains a challenge. As most cases of HCM are familial, evaluation of first-degree relatives and other family members at risk of inheriting the disease should be a routine component of clinical management.

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Section: Clinical Managementmentioning

confidence: 95%

Hypertrophic cardiomyopathy in children

Moak

Kaski

2012

Heart

100

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“…The enzymatic curve of Creatine Kinase myocardium fraction isoenzymes MB together with troponin elevation were monitored, and the maximum peak levels of CK-MB fraction was 471U/L and for troponin 215.4 lg/L. the child was discharged in an asymptomatic state [11]. No other complications were observed after the procedure and the child remained in hospital for six days to be sure he would not develop late complete heart block.…”

Section: Asa Techniquementioning

confidence: 98%

Alcohol septal ablation after myomectomy failure solutions for unusual cases

Cano

Sousa

2010

Cathet Cardio Intervent

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We report an eight-year-old child presented with classical features of hypertrophic obstructive cardiomyopathy and with New York Heart Association (NYHA) class III symptoms, eight months after myectomy and refractory to medical treatment. Cardiac transplantation was indicated due to the severity of symptoms. But the lymphocyte reaction test showed almost 100% reaction of antibodies, and the surgeons rejected the heart transplantation for fear of hyperacute rejection. Then an alcohol septal ablation (ASA) was proposed, which was successfully performed on August 17, 2005. The post-extrasystolic gradient was reduced from 160 to 60 mm Hg immediately and no other complications were seen. The child is being followed since then and echocardiography changes include a further reduction of septum thickness and gradient (P = 0.001), and important symptoms relieved after 3.5 years of follow up. ASA may be an option to be considered in children with critical hypertrophic obstructive cardiomyopathy in NYHA functional class III/IV, when other methods of treatment failed. © 2010 Wiley-Liss, Inc.

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Percutaneous Transluminal Septal Myocardial Ablation in a Child with Hypertrophic Obstructive Cardiomyopathy and Noonan Syndrome

Cited by 2 publications

References 21 publications

Hypertrophic cardiomyopathy in children

Hypertrophic cardiomyopathy in children

Alcohol septal ablation after myomectomy failure solutions for unusual cases

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