Percutaneous thermal ablation of medium and large hepatocellular carcinoma

Abstract

Knowledge about the triglyceride (fat) 1H spectrum enables quantitative determination of several triglyceride characteristics. This work describes a model‐based chemical shift imaging method that separates water and fat signal and provides maps of three triglyceride quantities: fatty acid carbon chain length, unsaturation degree, and polyunsaturation degree. The method was validated by imaging a phantom containing 10 different oils using 1.5 and 3.0 T clinical scanners, with gas–liquid chromatography as reference. Repeated acquisitions demonstrated high reproducibility of the method. Statistical tests of correlation and linear regression were performed to examine the accuracy of the method. Significant correlation was found at both field strengths for all three quantities, and high correlation (r2 > 0.95) was found for measuring unsaturation degree and polyunsaturation degree. Feasibility of the method for in vivo imaging of the thigh was demonstrated at both field strengths. The estimates of unsaturation degree and polyunsaturation degree in subcutaneous adipose tissue were in agreement with literature values, while chain length appeared over estimated. The method has potential use in large‐scale cross‐sectional and longitudinal studies of triglyceride composition, and its relation to diet and various diseases. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.

Microwave Ablation Treatment of Liver Cancer with a 2,450-MHz Cooled-shaft Antenna: Pilot Study on Safety and Efficacy

“…The complete ablation rate was 93% for tumors measuring 4 cm or less and 38.5% for tumors larger than 4 cm, and the authors concluded that laparoscopic MWA is preferable for tumors of 4 cm or smaller. Yin XY et al (2009) reported using MWA or PRFA to treat 109 HCC patients with at least 1 tumor measuring between 3.0 cm and 7.0 cm. CA rate was 92.6%.…”

Microwave ablation treatment of liver cancer with 2,450-MHz cooled-shaft antenna: an experimental and clinical study

“…The CA rate was 93% for tumors measuring 4 cm or less and 38.5% for tumors larger than 4 cm, and the authors concluded that laparoscopic MWA was preferable for tumors of 4 cm or smaller. Yin et al (2009) reported using MWA or PRFA to treat 109 HCC patients with at least one tumor measuring between 3.0 and 7.0 cm. The CA rate was 92.6%; LR occurred in 22% patients, with a median time to LR of 4.6 months.…”

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

“…However, a trend favoring RFA was recognized in that study with respect to local recurrence and complication rates [62] . In another study by Yin et al [63] comparing the therapeutic efficacy of RFA and MWA in treating HCCs > 3 cm, both RFA and MWA were found to be effective and safe. Several studies have evaluated the efficacy of MWA when used alone in treating HCCs [63] .…”

“…In another study by Yin et al [63] comparing the therapeutic efficacy of RFA and MWA in treating HCCs > 3 cm, both RFA and MWA were found to be effective and safe. Several studies have evaluated the efficacy of MWA when used alone in treating HCCs [63] . Sato et al [64] , in one of the earliest studies, demonstrated the safety and efficacy of MWA in 19 patients with unresectable HCCs.…”