Percutaneous soft tissue release performed using a blunt cannula in rabbits with chronic collagenase-induced Achilles tendinopathy

Hsieh, Yueh‐Ling; Lin, Ming-Ta; Hong, Chang‐Zern; Chen, Hsin-Shui

doi:10.1016/j.fas.2017.10.007

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…The needle is inserted in front of the tendon, and then forward and backward movements are repeatedly performed to release the soft tissues and paratenon around the tendon until the needle is free to move [ 77 ]. In murine Achilles tendinopathy, PRST decreased the cellular inflammatory infiltrate present in the paratenon, and a reduction of substance P expression was observed in the dorsal horns of the spinal cord, suggesting a potential impact on pain regulatory mechanisms [ 77 ]. In humans, the technique was effective to reduce pain in patients suffering from chronic Achilles tendinopathy in a randomized study compared to mini-open surgery [ 68 ].…”

Section: Ultrasound-guided Procedures Without Injectionmentioning

confidence: 99%

Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy

Darrieutort-Laffite

Soslowsky

Goff

2020

IJMS

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Achilles tendinopathy (AT) is a common problem, especially in people of working age, as well as in the elderly. Although the pathogenesis of tendinopathy is better known, therapeutic management of AT remains challenging. Various percutaneous treatments have been applied to tendon lesions: e.g., injectable treatments, platelet-rich plasma (PRP), corticosteroids, stem cells, MMP inhibitors, and anti-angiogenic agents), as well as percutaneous procedures without any injection (percutaneous soft tissue release and dry needling). In this review, we will describe and comment on data about the molecular and structural effects of these treatments obtained in vitro and in vivo and report their efficacy in clinical trials. Local treatments have some impact on neovascularization, inflammation or tissue remodeling in animal models, but evidence from clinical trials remains too weak to establish an accurate management plan, and further studies will be necessary to evaluate their value.

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Section: Ultrasound-guided Procedures Without Injectionmentioning

confidence: 99%

Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy

Darrieutort-Laffite

Soslowsky

Goff

2020

IJMS

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“…35 Achilles tendinopathy, especially seen in athletes and manual labor workers, is an inflammatory condition characterized by chronic tendon pain attributed to repetitive activity. 18 Local inflammatory responses in tendinopathy are characterized by the presence of matrix metalloproteinases (MMPs) as well as proinflammatory cytokines. As a result, the cells forming the tendon tissues are damaged and cause the tissue integrity to deteriorate.…”

mentioning

confidence: 99%

“…26 Therefore, suppressing inflammatory responses with multiple pharmacological treatments, such as nonsteroidal anti–inflammatory drugs and corticosteroid injections, is recommended to support the healing of such injuries. 18,26 However, these treatments improve only some of the symptoms of tendinopathy and cause various side effects. 26 For example, 1 study 14 reported that the administration of high doses of diclofenac caused an increase in ALT, AST, ALP, urea, and creatinine levels in Wistar albino rats; in addition to these, ulcers formed in the intestinal mucosa.…”

mentioning

confidence: 99%

Evaluation of Therapeutic Effects of Quercetin Against Achilles Tendinopathy in Rats via Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Metalloproteinases

et al. 2021

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Background: Achilles tendinopathy, seen in athletes and manual labor workers, is an inflammatory condition characterized by chronic tendon pain. Owing to the toxicity that develops in various organs attributed to the use of anti–inflammatory drugs, there is a need for new therapeutic agents. Purpose: In the present study, the effects of quercetin (Que), the one that attracted the most attention of researchers studying this group of flavonoids, were investigated against collagenase–induced tendinopathy. Study Design: Controlled laboratory study. Methods: A total of 35 Sprague-Dawley rats were used in the study. Tendinopathy was created by injecting a single dose of collagenase (10 μL; 10 mg/mL) into the tendons of rats. Thirty minutes after the injection, Que was administered at doses of 25 or 50 mg/kg. Que administration was carried out for 7 days. Animals underwent a motility test at the end of the study. In addition, markers of oxidative stress, inflammation, apoptosis, and autophagy, as well as the expression levels of matrix metalloproteinases (MMPs 2, 3, 9, and 13), ICAM-1, and STAT3, were measured in tendon tissues with biochemical, molecular, and Western blot techniques. Results: The results showed that oxidative stress, inflammation, apoptosis, and autophagy were triggered by the injection of collagenase. In addition, MMPs, ICAM-1, and STAT3 were activated to participate in the development of tendinopathy. Que was found to reduce ICAM-1 levels in tendon tissue. Moreover, Que showed antioxidant, anti–inflammatory, antiapoptotic, and antiautophagic effects on tendons against tendinopathy. More important, Que suppressed the expression of MMPs in the tendon tissues. Conclusion: Que has protective properties against collagenase–induced tendon damage in rats. Clinical Relevance: We believe that with further study, Que may be shown to be an alternative treatment option for athletes or others who experience tendon injuries.

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“…Três estudos [25][26][27] avaliaram os efeitos da mobilização no tratamento da TC e observaram que essa intervenção reduziu a celularidade do tecido e expressão de proteínas que interferem no reparo tecidual. Entretanto, nesses estudos, destacam-se limitações, tais como a falta de clareza acerca dos papéis de várias proteínas encontradas por Jiliele et al 26 , a falta de outros grupos para comparação dos desfechos e a carência de cálculo amostral evidenciada no estudo de Imai et al 26 , além do curto período de avaliação e baixo número de intervenções realizados por Hsieh et al 27 .…”

Section: Discussionunclassified

“…Três estudos experimentais em modelo animal (16,7%) investigaram os efeitos da mobilização do tendão calcâneo na TC [25][26][27] . A mobilização contribuiu para diminuir a densidade celular e a expressão de neuropeptídios após lesão tendínea 25 , reduziu a expressão de proteínas que retardam o processo de recuperação tissular durante a cicatrização 26 e foi capaz de melhorar a orientação do colágeno no tecido, aumentado a área de secção transversal, embora sem melhorar aspectos biomecânicos 27 .…”

Section: Mobilizaçãounclassified

Fisioterapia Na Reabilitação De Tendinopatia Do Calcâneo: Uma Revisão

Rodrigues¹,

Sousa²,

Jesus³

et al. 2021

Cad Edu Saude e Fis

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A tendinopatia do calcâneo (TC) é uma condição dolorosa e disfuncional, recorrente em indivíduos ativos e sedentários. A etiologia da TC é incerta, e tratamentos clínicos nem sempre são eficazes, o que merece atenção da comunidade científica quanto ao emprego racional de recursos terapêuticos com melhor evidência científica. A presente revisão objetivou descrever as principais abordagens fisioterapêuticas aplicadas no tratamento da TC. A busca dos artigos foi realizada entre janeiro e outubro de 2018 nas bases de dados PubMed, PEDro, Bireme e Cochrane Controlled Trial Register, limitada aos últimos cinco anos. Foram consideradas para esta revisão os artigos disponíveis na íntegra, em inglês, com Qualis de A1 até B2 na área de avaliação 21, e que utilizassem a fisioterapia como intervenção terapêutica. Foram excluídos artigos de metanálise e aqueles associados a mais de um tipo de intervenção sem os devidos controles. De 4.198 artigos, apenas 18 foram elegíveis, sendo 12 estudos experimentais em modelo animal e 6 ensaios clínicos. Os estudos experimentais mostraram vantagens na redução da dor e inflamação ao usar a fotobiomodulação como terapia única, bem como associado a outras terapias. Já a estimulação mecânica e a mobilização tecidual foram vantajosas quanto às propriedades biomecânicas e histológicas dos tendões lesionados. Nos ensaios clínicos, foram observadas melhorias nos escores de dor, mobilidade, função e força muscular em todas as abordagens terapêuticas, embora o exercício terapêutico excêntrico seja a abordagem mais recorrente. As abordagens fisioterapêuticas para o tratamento da TC com melhor evidência científica compreendem a fotobiomodulação e a estimulação mecânica por mobilizações e exercícios, sendo fortemente recomendadas para a prática clínica.

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Percutaneous soft tissue release performed using a blunt cannula in rabbits with chronic collagenase-induced Achilles tendinopathy

Cited by 4 publications

References 27 publications

Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy

Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy

Evaluation of Therapeutic Effects of Quercetin Against Achilles Tendinopathy in Rats via Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Metalloproteinases

Fisioterapia Na Reabilitação De Tendinopatia Do Calcâneo: Uma Revisão

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