Cholecystitis and gallbladder disease are an important, growing, and costly problem. As interventional radiology (IR) and gastroenterology (GI) have evolved and become even more minimally invasive and technically capable, we play an increasingly important role in the management of cholecystitis, particularly in nonsurgical and palliative settings. This review highlights the modern and future role of IR and GI in gallbladder drainage for the management of acute cholecystitis.