Percutaneous renal graft biopsy: a clinical, laboratory and pathological analysis

Abstract

Evaluation of serum creatinine and urinalysis can be useful in suggesting the histological graft diagnosis.

Biopsy Findings in Renal Allograft Dysfunction in a Live Related Renal Transplant Program

“…CNI toxicity was also a major cause of allograft dysfunction in the acute setting in our patients. The diagnosis of this complication is often difficult and challenging [2,15,[16][17][18][19]. The toxicity of the drugs may be caused in the face of normal or even low levels of the drug in the blood.…”

“…Renal allograft biopsy is the gold standard to accurately establish the cause of renal allograft dysfunction [3,8,9]. It is generally felt that the causes of graft dysfunction vary in live related vs. cadaveric renal transplant settings as well as in different immunosuppressive protocols [10][11][12][13][14][15][16][17][18][19][20][21]. There are also center to center, and inter-institutional variations in the quality and the incidence of rejection [22][23][24][25][26].…”

“…There are also center to center, and inter-institutional variations in the quality and the incidence of rejection [22][23][24][25][26]. There are very few studies exclusively on the causes of graft dysfunction in a live related renal transplant program [10][11][12][13][14][15].…”

Biopsy of the Transplanted Kidney

“…Some authors have suggested an increase in serum creatinine of 25% above the baseline as in indication for transplant renal biopsy. 10 Other early clinical indicators of allograft rejection include unexplained fever, edema, hypertension, eosinophilia, oliguria, anuria, and proteinuria unrelated to glomerulonephritis. Clinical criteria alone cannot predict graft dysfunction in 50% to 70% of the patients; therefore, histological confirmation of the diagnosis is often required.…”

Pathology of Renal Transplantation

“…The renal allograft biopsy plays an important role in the diagnosis and management of causes of renal allograft dysfunction (Al-Awwa et al, 1998;Colvin,1996;Gaber, 1998;Mazzali et al, 1999;Matas et al, 1983;Matas et al, 1985;Parfrey et al, 1984). Regarding biopsy indications, it is befitting to state that it is always indicated to answer a clinical question.…”