To differentiate the outcomes of percutaneous nephrolithotomy (PCNL) discharged in the prone posture versus the supine posture in multiple renal stones. Materials and Methods:-Comparative prospective randomized study of 30 cases divided into two sectors sector A included 15 cases in the supine posture and sector B included 15 cases in the prone posture. The outcomes of a period of exposure to radiation, renal stone-free rate, body mass index (BMI), size of the stone, period of operation, hold up in the hospital, and complications were compared. Results:-There were no differences in age, gender, site of stone, body mass index, size of the stone, and the presence of hydronephrosis between the two sectors. The supine sector had a little mean surgical period (93 minutes vs. 123 minutes, p<0.001), shorter mean to hold up in hospital (2 days vs. 3 days, p=0.005), and stone-free rate (70% vs. 50%, p=0.271). There were no variance in infection or bleeding complications but the prone sector had a forceful ratio of complications. Conclusions:-In cases with multiple renal stones with a stone size of more than 2 cm, the supine PCNL has an issue to the prone PCNL concerning the operative period, holding up in a hospital with a similar rate of complications with the prone PCNL.