Percutaneous microwave ablation of stage I medically inoperable non‐small cell lung cancer: Clinical evaluation of 47 cases

Abstract

Purpose To retrospectively evaluate safety and effectiveness of CT-guided percutaneous microwave ablation (MWA) in 47 patients with medically inoperable stage I peripheral non-small cell lung cancer (NSCLC). Methods From February 2008 to October 2012, 47 patients with stage I medically inoperable NSCLC were treated in 47 MWA sessions. The clinical outcomes were evaluated. Complications after MWA were also summarized. Results At a median follow-up period of 30 months, the median time to the first recurrence was 45.5 months. The local control rates at 1, 3, 5 years after MWA were 96%, 64% and 48%, respectively. The median cancer-specific and median overall survivals were 47.4 months and 33.8 months. The overall survival rates at 1, 2, 3 and 5 years after MWA were 89%, 63%, 43%, and 16 %, respectively. Tumors ≤3.5 cm were associated with better survival than were tumors >3.5 cm. The complications after MWA included pneumothorax (63.8%), hemoptysis (31.9%), pleural effusion (34%), pulmonary infection (14.9%), and bronchopleural fistula (2.1%). Conclusions MWA is safe and effective for the treatment of medically inoperable stage I peripheral NSCLC.

Short-Term Outcomes and Safety of Computed Tomography-Guided Percutaneous Microwave Ablation of Solitary Adrenal Metastasis from Lung Cancer: A Multi-Center Retrospective Study

“…In general, the ablation power selected was 60–70 W and the ablative duration ranged from 4 to 8 minutes as decribed previously (1415). For tumors larger than 3.5 cm, ablation was performed with 2 antennas (14151617). Immediately after the MWA procedure, CT scanning was performed again to evaluate the tumor size, tumor morphology, and the status of adjacent organs.…”

Thermal Ablation of Lung Tumors: Focus on Microwave Ablation

“…Pain can be encountered after 2 -27.6 % of MWA ablations (▶ Table 1) [1,3,8,12]. Generally, the severity is mild to moderate, and it persists for a few days to a few weeks.…”

“…Intraparenchymal hemorrhages occur in 6 -10 % of MWAs and lead to hemoptysis in 0 -7 % of cases [2,3,16,22]. Yang et al reported a hemoptysis rate as high as 36 % [12]. These rates have been reported to be higher after RFA with 3 -9 % resulting in hemoptysis and an almost double in hemorrhage [54].…”

“…They appear more often if the ablation is subpleural and are caused by an inflammatory reaction of the pleura [13,86]. Large, symptomatic pleural effusions occur after 0 -7.7 % of treatments and can be managed by insertion of a drain [12,13,16,17,22].…”

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer

“…Non-surgical therapeutics are current alternatives, including stereotactic body radiation therapy (SBRT) (2-9), CT-guided percutaneous radiofrequency ablation (10-14) and bronchoscopic laser therapy (15, 16). New techniques such as CT-guided percutaneous microwave (17) and cryoablation (18) are under investigation as well. However, limitations still exist for each modality.…”