Percutaneous microwave ablation of renal cell carcinoma: practice guidelines of the ultrasound committee of Chinese medical association, interventional oncology committee of Chinese research hospital association

Yu, Jie; Yu, Xiaoling; Cheng, Zhigang; Hu, Bing; Han, Zhiyu; Liu, Fangyi; Hu, Zhiquan; Wang, Hui; Dong, Jun; Pan, Jie; Yang, Bo; Sai, Xiaoyong; Guo, Aitao; Liang, Ping

doi:10.1080/02656736.2020.1779356

Cited by 5 publications

(4 citation statements)

References 69 publications

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“…Minimally invasive thermal therapy has been gradually applied to treat solid tumors as standard local therapy, including hepatocellular carcinoma, lung cancer, renal carcinoma, thyroid tumor, and so on [4][5][6][7][8] . However, recurrence may still occur after local ablation of tumors.…”

Section: Discussionmentioning

confidence: 99%

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Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy

Tang,

Mao,

Ling

et al. 2024

Nat Commun

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Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains a concern. Central memory CD8+ T cells (TCM) play important roles in protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the memory phenotype of peripheral CD8+ T cells increases slightly after microwave ablation (MWA), the metabolism of peripheral CD8+ T cells remains unfavorable for memory phenotype. In mouse models, glycolysis inhibition by 2-deoxy-D-glucose (2DG) in combination with MWA results in long-term anti-tumor effect via enhancing differentiation of tumor-specific CD44hiCD62L+CD8+ TCM cells. Enhancement of CD8+ TCM cell differentiation determined by Stat-1, is dependent on the tumor-draining lymph nodes (TDLN) but takes place in peripheral blood, with metabolic remodeling of CD8+ T cells lasting the entire course of the the combination therapy. Importantly, in-vitro glycolysis inhibition in peripheral CD8+ T cells of patients with breast or liver tumors having been treated with MWA thrice leads to their differentiation into CD8+ TCM cells. Our work thus offers a potential strategy to avoid tumor recurrence following MWA therapy and lays down the proof-of-principle for future clinical trials.

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Section: Discussionmentioning

confidence: 99%

“…including hepatocellular carcinoma, lung cancer, renal carcinoma, thyroid tumor, and so on [4][5][6][7][8] . Several clinical trials have confirmed the local effect of ablation therapies with high complete ablation rates in the treatment of breast cancer [9][10][11] .…”

mentioning

confidence: 99%

Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy

Tang,

Mao,

Ling

et al. 2024

Nat Commun

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“…MWA is increasingly used in the treatment of RCC and has achieved certain clinical results [ 7 , 8 ]. In a propensity-matched cohort study of 1955 patients with percutaneous MWA and laparoscopic PN for the treatment of cT1a RCC, it was found that there were no significant differences regarding oncologic outcomes and complications between the two therapies [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

MR-Guided Microwave Ablation in T1 Renal Cell Carcinoma: Initial Results in Clinical Routine

Jiao

Wang

et al. 2021

BioMed Research International

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Objective. Percutaneous tumor ablation is usually performed using computed tomography (CT) or ultrasound (US) guidance, although reliable visualization of the target tumor could be challenging. Magnetic resonance- (MR-) guided ablation provides more reliable visualization of the target tumors and allows multiplanar imaging of the treatment process, making it the modality of choice, in particular if lesions are small. Methods. From March 2016 to January 2018, 32 patients scheduled for percutaneous treatment of T1 RCC underwent MR-guided MWA. Complications were classified according to the Clavien grade. Kaplan–Meier survival estimates were calculated to evaluate progression-free survival (PFS). Results. Technical success was achieved in all lesions. The mean energy and procedure duration were 61.6 ± 8.7 kJ and 118.2 ± 26.7 min, respectively. The glomerular filtration rate (GFR) dropped rapidly after 1 month of treatment and slowly recovered within three months ( P < 0.05 ). Postoperative pain and fever were the most common adverse events after treatment. Perirenal hematoma, thermal injury of the psoas muscle, and abdominal distension were common complications after MWA, and the incidence rates were 9.4% (3/32), 6.3% (2/32), and 6.3% (2/32), respectively. According to the Clavien grade classification, serious complications include hydrothorax, bowel injury, and renal failure, all of which have a probability of 3.1%. Of note, the three serious complications occurred in one patient. The 1-, 2-, and 3-year PFS rates were 96.9%, 93.8%, and 83.9%, respectively. The mean PFS rates were 33.972 months (95% CI: 33.045, 35.900). Conclusion. Microwave ablation is feasible under MR guidance and provides effective treatment of RCC in one session.

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“…This technique allows accurate positioning and planning of the ablation range, causes less trauma, takes less time to perform, has a wide application range, results in fewer postoperative complications, is repeatable, and can treat multiple lesions simultaneously [17,18]. MWA is now widely used in the treatment of a variety of solid tumors in various parts of the body [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of Ultrasound-Guided Microwave Ablation for Nonpuerperal Mastitis Treatment

Zhou

Sheng

et al. 2022

Breast Care

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Introduction: This study investigated the feasibility of ultrasound (US)-guided microwave ablation (MWA) as a treatment for non-puerperal mastitis (NPM). Methods: Fifty-three patients with NPM diagnosed by biopsy and treated with US-guided MWA at the Affiliated Hospital of Nantong University between September 2020 and February 2022 were classified according to whether they underwent MWA alone (n=29) or MWA with incision and drainage (n=24). Patients were followed up by interviews, physical and US examinations, and evaluation of breast skin at 1 week and 1, 2, and 3 months after treatment. Data from these patients were prospectively collected and retrospectively analyzed. Results: The overall mean patient age was 34.42 ± 9.20 years. The groups differed significantly by age, involved quadrants, and the initial maximum diameter of lesions. In the MWA group, the cure rate was 34.48%, and the apparent efficiency rate was 65.52%. In the MWA with incision and drainage, the apparent efficiency rate was 91.66%, and the effective rate was 4.17%. The excellent rate for breast aesthetics in the MWA group was 79.31% and the good rate was 20.69%. The excellent rate in the MWA with incision and drainage group was 45.83%, the good rate was 41.67%, and the qualified rate was 12.5%. The mean maximum diameter of lesions in the two groups decreased significantly. Discussion/Conclusion: For NPM with small lesions in a single quadrant, MWA therapy is a direct and effective method. For larger lesions involving two or more quadrants, the combined treatment of MWA with incision and drainage showed significant improvement in a short period. MWA treatment of NPM has importance for further research and clinical applications.

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Percutaneous microwave ablation of renal cell carcinoma: practice guidelines of the ultrasound committee of Chinese medical association, interventional oncology committee of Chinese research hospital association

Cited by 5 publications

References 69 publications

Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy

Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy

MR-Guided Microwave Ablation in T1 Renal Cell Carcinoma: Initial Results in Clinical Routine

A Preliminary Study of Ultrasound-Guided Microwave Ablation for Nonpuerperal Mastitis Treatment

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