Percutaneous liver biopsy with the Menghini needle

Parets, Albert D.; Schaffner, Fenton; Black, Hannah

doi:10.1007/bf02232174

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Liver tissue was obtained from unanesthetized animals either percutaneously with a 1.4 X 70 mm Menghini liver biopsy needle 16 or by laparotomy after stunning the animal by a blow on the head. Small pieces of the tissue less than a millimeter in diameter were placed in cold barbiturate buffered osmium tetroxide-sucrose solution for an hour.…”

Section: Methodsmentioning

confidence: 99%

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Electron Microscopy as Related to Hepatotoxicity*

Schaffner

Kniffen

1963

Annals of the New York Academy of Sciences

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On the basis of light microscopic studies, drug reactions involving the liver have been classified as hepatitic, cholestatic, and toxic. 1 The last is the result of administration of poisons affecting all species and all indi viduals in a clear dose related fashion and with a distinctive morphologic picture. These chemicals, usually organic solvents best exemplified by carbon tetrachloride, have been widely used in experimental models of hepatic injury. However, most drug reactions in the liver occur infre quently, are not clearly dose related, and mimic other diseases of the liver and biliary tract, particularly viral hepatitis and extrahepatic biliary obstruction, as far as clinical, laboratory, and morphologic features are concerned. In an effort to effect a separation of drug-induced hepatic injury from other diseases, liver biopsy specimens were examined electronmicroscopically. Cholestasis following drug administration was found to be associated with changes of bile canaliculi, whereas hepatitis-like reactions seemed to primarily alter endoplasmic reticulum. 2 · 3 Many drug reactions with cholestasis were accompanied by bile canalicular dilatation and microvillar loss and shortening. 2 · 4 · 5 However, similar changes were also found in extrahepatic biliary obstruction, 69 in viral hepatitis, 2 and in liver disease in alcoholic persons. 10 Therefore, the canalicular changes failed to provide a means of differential diagnosis of the causes of cholestasis, particularly hepatic disease versus biliary tract obstruction. The electronmicroscopic studies did indicate that short term administration of drugs such as norethandrolone, known to produce cholestasis in some persons, and retention of Bromsulphalein in most persons 11 · 12 caused canalicular dilatation even in the absence of jaundice, and the same find ings were noted in rats given the drug. 6 In rats, however, the light micro scopic hallmark of cholestasis, namely bile thrombi, are not seen. In addition to electronmicroscopic changes in bile canaliculi, the enzyme histochemical reactions of the bile canaliculi were altered.

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Section: Methodsmentioning

confidence: 99%

“…Small pieces of the tissue less than a millimeter in diameter were placed in cold barbiturate buffered osmium tetroxide-sucrose solution for an hour. They were then dehy drated, embedded in Epon 812, 16 sectioned on a Porter Blum microtome, stained with uranyl acetate, 17 and examined with a Philips EM 100 microscope.…”

Section: Methodsmentioning

confidence: 99%

Electron Microscopy as Related to Hepatotoxicity*

Schaffner

Kniffen

1963

Annals of the New York Academy of Sciences

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“…Über günstige Ergebnisse mit der Nadel nach Menghini haben bereits Norris. Singh und Montuschi [32], Paréis [33] …”

Section: Abb Iunclassified

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Mangold¹

1960

Digestion

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Percutaneous aspiration liver biopsy using a large-caliber disposable needle

et al. 1977

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A modification of the aspiration liver biopsy technique using a large-caliber disposable needle is described in an 18-month experience. One hundred forty liver biopsies were performed, obtaining adequate tissue in 98% of the patients. Complications occurred in 12 patients and were limited to pain at the biopsy site, epigastrium, or right shoulder; one instance of tachycardia and three of transient hypotension occurred. Thirty patients studied prospectively with liver scans and hematologic parameters failed to disclose subclinical complications. While the number of patients biopsied is still too small to provide definite conclusions , it appears that this technique is safe, similar and has a very high yield of excellent specimens. In addition, the needle offers the advantage of being disposable and easy to use by a single operator.

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Percutaneous liver biopsy with the Menghini needle

Cited by 9 publications

References 5 publications

Electron Microscopy as Related to Hepatotoxicity*

Electron Microscopy as Related to Hepatotoxicity*

Anzeigen, Gefahren und Ergebnisse der Leberbiopsie

Percutaneous aspiration liver biopsy using a large-caliber disposable needle

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