Background: This retrospective study introduced an alternative treatment of types A2, A3, and B1 distal radius fractures using percutaneous pinning with cemented K-wire frame. Methods: From January 2017 to January 2020, 78 patients with distal radius fractures were treated with percutaneous pinning and cemented K-wire frame. There were 14 male patients and 4 female patients. There were types A2 (n=10), A3 (n=46), and B1 (n=22) fractures. X-rays were taken immediately after surgery and after bone healing. Wrist function was assessed with Mayo Wrist Score to assess wrist function (90–100, excellent; 80–90, good; 60–80, satisfactory; below 60, poor). Patient satisfaction on the upper limb was assessed using the 10-cm visual analog scale. Results: The data showed the fragments were kept in place without significant redisplacment (P>0.05). No wire loosening was found. All K-wires were kept in place without bone lessening. Fixation failure or osteomyelitis was not observed in this series. Bone healing was achieved in all patients at a mean of 4.5 months (range, 4 to 8 months). Follow-ups lasted for a mean of 27 months (range, 24 to 33 months). The mean score of wrist function was 97 (range, 91 to 100), including 66 excellent and 12 good results. The mean patient satisfaction was 10 cm (range, 8 to 10 cm).Conclusions: Percutaneous pinning with cemented K-wire frame is a safe and preferred choice for the treatment of types A2, A3, and B1 distal radius fractures. The frame provides support to prevent wire migration. The fixation is a minimally invasive technique that is easy to perform. Level of Evidence: Therapeutic study, Level IVa.