Percutaneous Intervention to Treat Platypnea–Orthodeoxia Syndrome

Abstract

Patients presenting with platypnea-orthodeoxia syndrome can be treated successfully with a percutaneous intervention often requiring a variety of devices. Those requiring a non-PFO-type device had a greater prevalence of an aneurysmal septum, shorter primum septal overlap with the secundum septum, and greater septal angulation with the midline.

Percutaneous Closure of PFO in Patients with Reduced Oxygen Saturation at Rest and during Exercise: Short- and Long-Term Results

“…e technique of percutaneous PFO closure has been reported to be safe, and the present data confirm this finding [5,[13][14][15][16]. Indeed, no major procedure-related complications were observed and the overall mortality was not related to the intervention.…”

“…More specifically, QoL assessed with the SF-36 indicated that most patients after PFO closure experienced a QoL which exceeds that of COPD patients and almost equaled that of a standard population. e improvement in SaO 2 seen in the current study was smaller than what has been reported in previous studies [5,[13][14][15][16]. In these studies, however, preprocedural mean SaO 2 was lower, and, hence, there was more room for improvement.…”

“…Only two of these contained substantially more patients than the present series [5,[13][14][15][16]. ese studies are not completely comparable to the current one, as some series contain only patients with platypnea-orthopnea syndrome (POS), while others included only patients with hypoxemia [5,[13][14][15][16]. Our study included all patients with PFO-related dyspnea and/or hypoxemia.…”

“…A large number of patients included in the present study suffered from severe cardiopulmonary comorbidities, a finding also reported in other studies. Interestingly, pneumonectomy, ascending aorta aneurysm (or dilation), and right hemidiaphragm elevation were also reported in the four other studies, but not in that of Ilkhanoff [5,[13][14][15][16]. However, in the latter study, almost all patients suffered from chronic pulmonary disease and congestive heart failure.…”

Patent Foramen Ovale: Pivotal Role of Transesophageal Echocardiography in the Indications for Closure, Assessment of Varying Anatomies and Post-procedure Follow-up

“…Most of the cases with PFO are patients with additional pulmonary diseases such as chronic lung disease and pneumonectomy. Closure in POS could be considered in cases of severe symptomatic hypoxia in the absence of pulmonary hypertension (Mojadidi et al 2019;Shah et al 2016). In divers, albeit the incidence of decompression sickness is rare, the presence of PFO could cause venous bubbles to go into the arterial circulation and lead to cerebral or myocardial infarction.…”