Percutaneous interface biopsy in dry-aspiration cases of chronic periprosthetic joint infections: A technique for preoperative isolation of the infecting organism

Corona, Pablo S.; Gil, Emilia; Guerra, Ernesto; Soldado, Francisco; Amat, Carles; Flores, Xavier; Pigrau, Carles

doi:10.1007/s00264-011-1418-0

Cited by 26 publications

(14 citation statements)

References 21 publications

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“…We can therefore assume that the absolute numbers of such infections will continue to rise. In addition there is a high estimated number of unreported cases due to difficulty in proving infection [4,5].…”

Section: Introductionmentioning

confidence: 99%

Periprosthetic joint infection—effect on quality of life

Helwig

Morlock

Oberst

et al. 2014

International Orthopaedics (SICOT)

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Purpose Relatively little is known about the extent to which periprosthetic joint infections (PJI) affect the patient's longterm quality of life (QoL). Our study aim was to assess the effect of a periprosthetic infection on our patients' QoL. Methods We collected data retrospectively of patients who had undergone surgery in our institution between 2006 and 2011. To capture their overall QoL, we telephoned the patients who could be reached and asked them the questions on the SF-12 questionnaire. Results In 84 patients (53 male, 31 female, 43 TKA and 41 THA), 88 % of the hip infections and 62 % of the knee infections had been successfully treated. The hip infections' cure rate was significantly higher than that of the knee joint infections.The average SF-12 score was 36.2 points on the physical scale and 52 on the mental scale. The difference in QoL between patients with and without successful infection therapy was not significant, nor did the site of the infection (knee or hip) influence QoL significantly.Comparison of our patients' QoL data to that from the general population revealed a significant difference in the physical scale but not the mental scale. Conclusion From these results QoL is substantially reduced after a prosthetic infection. We did however observe that postGirdelstone procedure patients or those with an arthrodesis attained an acceptable QoL, and that those methods remain therapeutic alternatives as far as patient-perceived QoL is concerned.

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Section: Introductionmentioning

confidence: 99%

Periprosthetic joint infection—effect on quality of life

Helwig

Morlock

Oberst

et al. 2014

International Orthopaedics (SICOT)

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“…Some authors used synovial biopsy to correctly diagnose the germ, but the methodologies varied, and inconsistent results were obtained . Biopsies of the periprosthetic tissue from the space between the prosthesis and the bone were also published . The authors describe a sensitivity of 88%.…”

Section: Discussionmentioning

confidence: 99%

Polylactic‐co‐glycolic acid microspheres added to fixative cements and its role on bone infected architecture

et al. 2019

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Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge. The aim of this study is to evaluate the response of bone tissue in rabbits after introduction of a hydroxyapatite‐coated titanium rod with a commercial fixative cement (Palacos®) compared to a modified experimental cement (EC) containing polylactic‐co‐glycolic acid (PLGA) microspheres in the presence or absence of contaminating germs. This study used 20 New Zealand rabbits which were divided into four groups (n = 5) depending on the presence or absence of S. aureus and the use of commercial (Palacos®) or EC. A histological method, based on bone architecture damage, was proposed to evaluate from 1 to 9 the histological results and the response of the infected tissue. The macrophage response was also evaluated using monoclonal antibody RAM‐11. The study showed better bone conservation with the use of EC with PLGA microspheres against the Palacos® commercial cement, including the noncontaminated and contaminated groups. © 2019 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2517–2526, 2019.

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“…The inability to obtain synovial fluid in some cases, particularly those in which a spacer is in place, and the invasiveness of joint aspiration have led some authorities to seek other methods for diagnosing periprosthetic joint infection, such as percutaneous biopsy, which is invasive, or testing for serum biomarkers, which is less invasive 30,31 . Not only do serum biomarkers hold promise for the diagnosis of periprosthetic joint infection, they also may be used to determine the resolution of periprosthetic joint infection and to aid in the identification of the optimal timing for reimplantation during a two-stage exchange arthroplasty.…”

Section: Serum Biomarkersmentioning

confidence: 99%