Percutaneous Image-Guided Radiofrequency Ablation of Painful Metastases Involving Bone: A Multicenter Study

Goetz, Matthew P.; Callstrom, Matthew R.; Charboneau, J. William; Farrell, Michael; Mans, Timothy P.; Welch, Timothy J.; Wong, Gilbert Y.; Sloan, Jeff A.; Novotny, Paul J.; Petersen, Ivy A.; Beres, Robert A.; Regge, Daniele; Capanna, Rodolfo; Saker, Mark B.; Grönemeyer, Dietrich; Gevargez, A.; Ahrar, Kamran; Choti, Michael A.; Debaere, Thierry; Rubin, Joseph

doi:10.1200/jco.2004.03.097

Cited by 555 publications

(316 citation statements)

References 30 publications

Supporting

Mentioning

277

Contrasting

Unclassified

Order By: Relevance

“…Bone metastasis is a common problem in cancer patients and can cause pain and morbidity, particularly depression and anxiety (5). Treatment with external beam radiotherapy is the standard of care for patients with localized metastatic bone pain.…”

Section: Discussionmentioning

confidence: 99%

“…By destroying tumor cells, RFA may decrease the production of cytokines and tumors factors involved in both nerve sensibilization and osteoclastic activity (5). RFA may also prevent the painful consequences of disease progression by inhibiting tumor growth (5). A multidisciplinary team approach should be employed when considering RFA for palliation, and consultation between the interventional radiologist, medical and/or surgical oncologist, and supportive care department members is ideal (27).…”

Section: Discussionmentioning

confidence: 99%

“…For direct nerve ablation, nociceptive input into the central nervous system is interrupted (5,25,26); another potential mechanism is a decrease in intratumoral pressure, leading to decrease pressure on adjacent nerves (1,27). By destroying tumor cells, RFA may decrease the production of cytokines and tumors factors involved in both nerve sensibilization and osteoclastic activity (5). RFA may also prevent the painful consequences of disease progression by inhibiting tumor growth (5).…”

Section: Discussionmentioning

confidence: 99%

“…Radiofrequency ablation (RFA) has long been used to treat painful disorders such as trigeminal neuralgia or osteom osteoid (2), and recent developments in technology and image guidance have allowed this invasive technique to treat solid tumors (1,3). The first application concerned unresectable liver tumors, but other studies have shown that this technique could offer a valuable treatment option for other unresectable tumors (3)(4)(5). We report our experience with the use of RFA in palliative supportive care.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Radiofrequency ablation in palliative supportive care: Early clinical experience

Marchal

Brunaud²,

Bazin³

et al. 2006

Oncol Rep

View full text Add to dashboard Cite

Abstract. We report our early experience with radiofrequency ablation (RFA) in palliative supportive care. The medical files of eight patients were retrospectively reviewed. Four patients had a renal tumor, and nephrectomy was contraindicated in each patient since they had a poor general status. The fifth patient had a local recurrence in the site of a previous nephrectomy with a pancreatic tail extension, and surgical resection was contraindicated because of abdominal carcinomatosis. Two other patients had bone metastasis, one with a painful metastasis of mammary carcinoma in the head of the humerus resistant to radiotherapy, and the other with metastasis of the tibia of cutaneous melanoma. The last patient had a local recurrence of a sacral chordoma. Management, outcomes and complications were evaluated with 13.1±0.3 months follow-up. All five patients with renal carcinomas did not have local recurrence. The two patients treated for bone metastases had no pain 8 weeks after RFA and remained stable over time. One complication occurred 2 months after using the procedure to treat the chordoma, and this patient was hospitalized for a fistula between the sigmoid and hypogastric artery false aneurysm and subsequently died. In conclusion, RFA can be a safe and useful adjuvant treatment in supportive care or unresponsive cancer pain patients. However, the destruction of tumoral tissues in contact with sensitive structures using RFA should be done with caution due to potentially severe complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiofrequency ablation in palliative supportive care: Early clinical experience

Marchal

Brunaud²,

Bazin³

et al. 2006

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…Heating energy can be generated by microwaves, RF, high-intensity US or laser. 3,4 Thermal ablation also includes cryotherapy, in which tumour necrosis is achieved by freezing to below -20ºC. 5 Image-guided RF thermal ablation (RFTA) is a branch of interventional oncology that uses direct application of RF-generated heat to coagulate and destroy tumour tissue.…”

mentioning

confidence: 99%