Percutaneous fetoscopic tracheal balloon occlusion in sheep

Abstract

Percutaneous fetoscopic balloon occlusion of the fetal trachea can effectively and safely be achieved in sheep. Because intraamniotic spatial relationships, fetal position, and umbilical cord length are technically less favorable in sheep, our operative techniques might be feasible in humans even if difficult intraamniotic conditions are encountered.

Naphthalene Amidine Imide Dyes by Transamination of Naphthalene Bisimides

“…Currently, severe CDH can be treated in utero by percutaneous fetoscopic tracheal occlusion (FETO)5, in which an inflated balloon is placed via the larynx into the trachea to provoke a surge in lung growth that may reverse pulmonary hypoplasia6. This method, however, is associated with a relatively high rate (52–100%) of preterm premature rupture of membranes (PPROM) and preterm delivery7, 8.…”

Minimally invasive fetoscopic interventions: an overview in 2010

“…Quintero et al [7] were the first to report percutaneous single-trocar fetoscopic tracheal occlusion in a human fetus. Since then, the technique has been refined further in animal studies [57][58][59]. Like other single-trocar techniques, percutaneous fetoscopic tracheal balloon occlusion can be performed using maternal local anesthesia combined with fetal analgo-sedation and relaxation (Fig.…”

Ultrasound‐guided injection and occlusion of the trachea in fetal sheep

“…Currently, severe CDH can be treated in utero by percutaneous fetoscopic tracheal occlusion (FETO) 5 , in which an inflated balloon is placed via the larynx into the trachea to provoke a surge in lung growth that may reverse pulmonary hypoplasia 6 . This method, however, is associated with a relatively high rate (52-100%) of preterm premature rupture of membranes (PPROM) and preterm delivery 7,8 .…”