Percutaneous Ethanol Injection of Large Autonomous Hyperfunctioning Thyroid Nodules

Tarantino, L.; Giorgio, Antonio; Mariniello, N.; Stefano, G. de; Perrotta, A.; Aloisio, V.; Tamasi, Sonia; Forestieri, MC; Esposito, Francesco; Finizia, L; Voza, A

doi:10.1148/radiology.214.1.r00ja13143

Cited by 38 publications

(27 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They all have some advantages on surgery: no hiatrogenic hypothyroidism, no scar formation, lesser costs. Adverse events are comparable: the most common major adverse effect, recurrent laryngeal nerve palsy, is 11.8% (9.8% transient, 2% permanent) in surgery (18) and 0-8% (only transient) in RFA and LA (6)(7)(8)17,(19)(20)(21)(22)(23). PEI has revealed to be useful for cystic nodules: it can be used with fine needles (21G), and is quite inexpensive and shows good results (53-80% reduction in volume) (24).…”

Section: Discussionmentioning

confidence: 99%

“…Surgery has in fact some limitations, like a 2-10% complication rate, hiatrogenic hypothyroidism, hospitalization, general anesthesia and scar formation (5). In the last years, non surgical minimally invasive techniques have been developed to treat this pathology, starting from percutaneous ethanol injection (PEI), to laser ablation (LA) and radiofrequency ablation (RFA) (6)(7)(8). Most recently, microwave ablation (MWA) has been proposed to treat thyroid nodules, taking experience from its use in other organs like liver, kidney and lung in particular (9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Morelli¹,

Sacrini²,

Pompili³

et al. 2016

Gland Surg.

View full text Add to dashboard Cite

Background: Thyroid nodules are a fairly common finding in general population and, even if most of them are benign, a treatment can be however necessary. In the last years, non surgical minimally invasive techniques have been developed to treat this pathology, starting from percutaneous ethanol injection (PEI), to laser ablation (LA), radiofrequency ablation (RFA) and, most recently, microwave ablation (MWA). Methods:We reviewed all medical literature searching in pubmed.gov the terms "microwave" & "thyroid".We found three original studies concerning MWA treatment, for a total of 263 patients (mean age 51.0 years; range, 15-80 years; male to female ratio 2.55) and 522 nodules.Results: A total of 522 nodules (338 solid, 22 cystic, 162 mixed) in 263 patients were treated. Studies have shown a mean reduction in volume of thyroid nodules ranging from 45.9% to 65%. No study reported a significant and definitive change in laboratory parameters, except for one case (Heck et al.). No studies have reported major complications after procedure.Conclusions: MWA is a new, promising technique among the minimally invasive treatments of thyroid nodules. Actually, the larger diameter of MW antenna seems to be the major limiting factor in the use of this technique. More studies are necessary to evaluate feasibility, safety and efficacy of the procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Morelli¹,

Sacrini²,

Pompili³

et al. 2016

Gland Surg.

View full text Add to dashboard Cite

show abstract

“…Studies that have examined the use of EA to treat benign solid thyroid nodules have shown varying levels of success, depending on nodule size, the volume of ethanol instilled, and the presence of nodule toxicity. [10][11][12][13][14] However, the author of this study has recently found that EA may be a viable alternative to RFA or surgery for the treatment of these nodules. 15 In addition, to the best of my knowledge, no study has previously examined the feasibility of using EA to remove any peripherally located solid components remaining after treatment of benign solid thyroid nodules with RFA.…”

mentioning

confidence: 88%

Sonography-Guided Ethanol Ablation of a Remnant Solid Component after Radio-Frequency Ablation of Benign Solid Thyroid Nodules: A Preliminary Study

Kim

2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…The conservative approach is not helpful for the uncomfortable feeling of a lump in the throat or cosmetic concerns. Therefore, nonsurgical, minimally invasive modalities, such as ethanol injection, laser ablation, and radiofrequency ablation (RFA), have been attempted, yielding good results (2,3,4,5).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Feng

Liang

Cheng

et al. 2012

European Journal of Endocrinology

124

125

View full text Add to dashboard Cite

Purpose: To obtain the treatment parameters of internally cooled microwave antenna and to evaluate the feasibility of ultrasound-guided percutaneous microwave ablation (MWA) for benign thyroid nodules. Materials and methods: MWAs were performed by microwave antenna (16G) in ex vivo porcine liver. The lesion diameters achieved in different groups (20, 25, and 30 W for 3, 5, 7, 10, and 12 min) were compared. The clinical study was approved by the ethics committee. Written informed consent was obtained from all patients. MWA was performed in 11 patients (male to female ratioZ1:10; mean age, 50G7 years) with 11 benign thyroid nodules. Ultrasound scan, laboratory data, and clinical symptoms were evaluated before and 1 day and 1, 3, 6, 9, and 12 months after the procedure. Results: In ex vivo study, the ablation lesion at 30 W 12 min tended to have appropriate scope and spherical shape. In clinical study, the follow-up periods ranged from 1 to 9 months. At the last followup, the largest diameter decreased from 2.9G1.0 (range, 1.6-4.1) to 1.9G0.7 (range, 0.4-3.0) cm (P!0.01), and the volume decreased from 5.30G4.88 (range, 0.89-14.81) to 2.40G2.06 (range, 0.02-6.35) ml (P!0.01). The volume reduction ratio was 45. 99G29.90 (range, 10.56-98.15) %. The cosmetic grading score was reduced from 3.20G0.79 to 2.30G0.95 (P!0.05). One patient experienced temporary nerve palsy and was recovered within 2 months after treatment. Conclusion: The internally cooled microwave antenna can yield ideal ablation lesions, and ultrasoundguided percutaneous MWA is a feasible technique for benign thyroid nodules.

show abstract

Percutaneous Ethanol Injection of Large Autonomous Hyperfunctioning Thyroid Nodules

Abstract: PEI is an effective and safe technique for the treatment of large hyperfunctioning thyroid nodules.

Cited by 38 publications

References 13 publications

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Sonography-Guided Ethanol Ablation of a Remnant Solid Component after Radio-Frequency Ablation of Benign Solid Thyroid Nodules: A Preliminary Study

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Contact Info

Product

Resources

About