Percutaneous Endoscopic Gastrostomy Tubes May Be Associated With Preservation of Lung Function in Patients With Cystic Fibrosis

Abstract

Background Improving nutrition status of patients with cystic fibrosis (CF) has a positive effect on pulmonary function. Methods We conducted a retrospective case‐control study evaluating the effect of percutaneous endoscopic gastrostomy (PEG) placement on body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1) between matched subjects with CF who received PEG (n = 20) and controls who did not (n = 40). Results We observed that after adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95% confidence interval (CI) = −0.05–1.08, P = .08), but decreased for those without PEG (−0.03, 95% CI = −0.33–0.28, P = .86); however, the difference (0.54; 95% CI = −0.10–1.18, P = .10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (−0.04; 95% CI = −0.30–0.22, P = .74) and those without PEG (−.22; 95% CI = −0.45–0.01, P = .06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95% CI = −0.17–0.52, P = .32) Conclusion Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.

Effectiveness of enteral nutrition by percutaneous endoscopic gastrostomy in malnourished patients with cystic fibrosis: Does the gender gap play a role?

“…3,4 Enteral nutrition (EN) administered via a percutaneous endoscopic gastrostomy (PEG) tube is a well-tolerated method to improve nutrition status, with a low incidence of complications. 5,6 There are no data on sex-related differences in the efficacy of EN via PEG in this population. We conducted a retrospective observational study in a cohort of 18 CF patients (11 male patients, 5/18 children) followed at a CF center in Florence, Italy, and requiring EN via PEG after the failure of conservative dietary measures.…”

Comparison of Tolerance and Complication Rates Between Early and Delayed Feeding After Percutaneous Endoscopic Gastrostomy Placement in Children

“…P ercutaneous endoscopic gastrostomy (PEG) placements are required by approximately 19 per 100,000 children each year (1). Common indications for PEG include dysphagia or oral feeding intolerance, prolonged impaired consciousness, and conditions requiring nutritional supplementation such as cystic fibrosis, prematurity, or severe malnutrition (2,3).…”

Comparison of general endotracheal anesthesia versus sedation without endotracheal intubation during initial percutaneous endoscopic gastrostomy insertion for infants: A retrospective cohort study

“…Percutaneous endoscopic gastrostomy (PEG) insertions are performed for a variety of indications including dysphagia, feeding intolerance, failure to thrive, and need for long‐term nutritional supplementation 14–18 . Neonates and infants receiving PEG therefore have significant underlying comorbidities including malnutrition, cardiopulmonary disorders, and neurologic disorders, 19–22 and are inherently at higher risk for complications of airway‐related adverse events during surgery.…”

“…13 Percutaneous endoscopic gastrostomy (PEG) insertions are performed for a variety of indications including dysphagia, feeding intolerance, failure to thrive, and need for long-term nutritional supplementation. [14][15][16][17][18] Neonates and infants receiving PEG therefore have significant underlying comorbidities including malnutrition, cardiopulmonary disorders, and neurologic disorders, [19][20][21][22] and are 29.6%) indicating that these infants may have had more severe disease than patients selected for monitored anesthesia care. Three monitored-anesthesia-care patients required intraoperative conversion to general anesthesia.…”