Percutaneous Endoscopic Gastrostomy Tube Insertion in Neurodegenerative Disease: A Retrospective Study and Literature Review

Sarkar, Pamela; Cole, A. F. D.; Scolding, Neil; Rice, Claire M

doi:10.5946/ce.2016.106

Cited by 43 publications

(43 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A further two studies demonstrated a correlation between ALS progression rate and impaired MSC function [25] , [26] , reporting that functional deficiencies in MSCs were proportional to disease progression. Moreover, MSC impaired functionality was also observed in multiple sclerosis (MS) patients [27] . In detail, conditioned media from MSCs of patients with long duration of progressive disease showed reduced neuroglial protective capacity.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

Angelova¹,

Barilani

Lovejoy³

et al. 2018

Redox Biology

106

View full text Add to dashboard Cite

Sporadic cases account for 90–95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism. Progressive Supranuclear Palsy (PSP) belongs to the atypical parkinsonian diseases and is histopathologically classified as a tauopathy. Here, we report that mesenchymal stem cells (MSCs) derived from the bone marrow of patients with PSP exhibit mitochondrial dysfunction in the form of decreased membrane potential and inhibited NADH-dependent respiration. Furthermore, mitochondrial dysfunction in PSP-MSCs led to a significant increase in mitochondrial ROS generation and oxidative stress, which resulted in decrease of major cellular antioxidant GSH. Additionally, higher basal rate of mitochondrial degradation and lower levels of biogenesis were found in PSP-MSCs, together leading to a reduction in mitochondrial mass. This phenotype was biologically relevant to MSC stemness properties, as it heavily impaired their differentiation into adipocytes, which mostly rely on mitochondrial metabolism for their bioenergetic demand. The defect in adipogenic differentiation was detected as a significant impairment of intracellular lipid droplet formation in PSP-MSCs. This result was corroborated at the transcriptional level by a significant reduction of PPARγ and FABP4 expression, two key genes involved in the adipogenic molecular network. Our findings in PSP-MSCs provide new insights into the etiology of ‘idiopathic’ parkinsonism, and confirm that mitochondrial dysfunction is important to the development of parkinsonism, independent of the type of the cell.

show abstract

Section: Discussionmentioning

confidence: 99%

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

Angelova¹,

Barilani

Lovejoy³

et al. 2018

Redox Biology

106

View full text Add to dashboard Cite

show abstract

“…Dysphagia results in significant morbidity by interfering with medication administration, nutrition and fluid intake, and is associated with aspiration pneumonia -the most frequent cause of death in patients with PS [2] . For PS patients presenting with dysphagia, the decision regarding gastrostomy tube insertion (GTI) for feeding is challenging since to date, few studies have addressed the procedural risks and outcomes in this patient population [3][4] . In contrast, there are already established recommendations for GTI to maintain nutritional support in patients with amyotrophic lateral sclerosis (ALS) that present with severe dysphagia.…”

Section: Maroismentioning

confidence: 99%

Outcome of gastrostomy in parkinsonism: A retrospective study

Marois

Amador

Payán

et al. 2017

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

show abstract

“…Parenteral nutrition is generally not preferred in such cases due to a number of shortcomings including the associated metabolic disorders, high cost, difficulty of application, as well as patient comfort. Enteral nutrition, as well as enteral feeding with PEG, are recommended in patients with chronic neurologic conditions such as head trauma, cerebral palsy, neuromuscular disorders, and motor neuron disorders (4,5,6,7,8,9,13,16,17,18,19). In a study by Tokunaga et al (19), 75.3% of their patients with PEG procedures were reported to have cerebrovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Experiences of Percutaneous Endoscopic Gastrostomy in our Neurology Intensive Care Unit Patients

Öcek¹,

Öcek²,

Damburacı³

2020

tnd

View full text Add to dashboard Cite

Objective: Nutritional support has significant clinical importance in patients with poor or no oral intake admitted to neurology intensive care units (NICU). Requirement for, administration methods, and benefits of active enteral feeding with feeding tubes remain a matter of dispute, particularly with respect to patients with impaired swallowing function following central nervous system involvement. In this study, we evaluated the patient characteristics and percutaneous endoscopic gastrostomy (PEG)-related problems in a group of patients in the NICU. Materials and Methods: Patients undergoing PEG and admitted to our NICU between May 2016 and March 2018 were retrospectively examined. Age, sex, duration of NICU stay, need for mechanical ventilation, occurrence of pneumonia, and PEG-related complications were recorded. Results: A total of 789 patients admitted to the NICU were screened. PEG use was identified among 41 (5.2%) of these patients, of whom 23 (56.1%) were female, with a mean age of 73.66±17.67 (range: 32-94) years. Twenty-nine (70.7%) of these patients with PEG use were diagnosed as having an ischemic etiology, and 7 (17.1%) had hemorrhagic cerebrovascular disease. The mean duration of NICU stay was 48.8±30.6 (range: 13-150) days. On average, PEG was used 29.12±7.97 (range: 13-42) days after admission. Twelve patients (29.3%) received mechanical ventilation, and 8 (19.5%) required a tracheostomy due to prolonged mechanical ventilator support. Prior to PEG, 25 (61.4%) patients had a diagnosis of pneumonia, and 15 (36.6%) patients developed pneumonia after PEG. PEG-associated nutritional intolerance developed in five (12.2%) patients. Conclusion: In agreement with the published literature, PEG-related complications were low in frequency and there were no cases of PEG-related mortality. In neurologic conditions associated with chronic and severe sequela requiring long-term nutritional support, PEG may be preferred on the basis of its ability to provide safe and physiologic nutrition, ease of use, and a low rate of complications.

show abstract

Percutaneous Endoscopic Gastrostomy Tube Insertion in Neurodegenerative Disease: A Retrospective Study and Literature Review

Cited by 43 publications

References 30 publications

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

Outcome of gastrostomy in parkinsonism: A retrospective study

Experiences of Percutaneous Endoscopic Gastrostomy in our Neurology Intensive Care Unit Patients

Contact Info

Product

Resources

About