Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl analogues

Fourie, L.; Breytenbach, Jaco C.; Plessis, Jeanetta du; Goosen, Colleen; Swart, Henk; Hadgraft, Jonathan

doi:10.1016/j.ijpharm.2004.04.007

Cited by 19 publications

(17 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liposomes are thermodynamically stable vesicles composed of one or more concentric lipid bilayers [76]. Liposomes have 2 compartments, an aqueous central core, and a lipophilic region within the lipid bilayer.…”

Section: Liposomes and Analoguesmentioning

confidence: 99%

“…However, the maximum concentration (C max ) and time to C max (T max ) were significantly lower and longer respectively, compared to subcutaneous injection. Vyteris, (Fair Lawn, NJ) has received approval for an iontophotetic patch containing lidocaine and adrenaline (LidoSite TM ) [76,255]. Adrenaline is a vasoconstrictor and reduces lidocaine clearance from the site.…”

Section: Iontophoresismentioning

confidence: 99%

“…When applied to stratum corneum, pulses are thought to induce formation of aqueous pores in the lipid bilayers. The aqueous pores may facilitate drug transport by passive diffusion, electroosmosis or iontophoresis during the pulse [18,76]. Furthermore, transdermal delivery of charged molecules may be further enhanced by iontophoretic transport through the transfollicular pathway during pulsation [281].…”

Section: Electroporationmentioning

confidence: 99%

“…Electroporation has the potential to enhance transdermal delivery of macromolecules. However, more clinical studies are required to assess long-term safety of this technique and to gain a greater understanding of its mechanism of action [76]. Miniaturisation of such devices is essential to facilitate routine use by patients.…”

Section: Electroporationmentioning

confidence: 99%

“…17). Devices can be powered by compressed air or by means of a compression spring [76]. There are essentially 2 types of jet injectors, liquid jet injector and powder jet injectors.…”

Section: Jet Injectionmentioning

confidence: 99%

See 4 more Smart Citations

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Morrow¹,

McCarron²,

Woolfson³

et al. 2007

TODDJ

View full text Add to dashboard Cite

Abstact: Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost layer, the epidermis, which safeguards against chemical, microbial, and physical attack. The exceptional barrier properties of the skin result in it being a challenging route for the delivery of therapeutic agents. This article reviews strategies developed to enhance the skin penetration of drugs, ranging from conventional approaches, for example the use of chemical penetration enhancers to those in early-stage development, such as microscissioning.

show abstract

Section: Liposomes and Analoguesmentioning

confidence: 99%

Section: Iontophoresismentioning

confidence: 99%

Section: Electroporationmentioning

confidence: 99%

Section: Electroporationmentioning

confidence: 99%

“…17). Devices can be powered by compressed air or by means of a compression spring [76]. There are essentially 2 types of jet injectors, liquid jet injector and powder jet injectors.…”

Section: Jet Injectionmentioning

confidence: 99%

See 3 more Smart Citations

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Morrow¹,

McCarron²,

Woolfson³

et al. 2007

TODDJ

View full text Add to dashboard Cite

show abstract

Microporation for Enhanced Transdermal Drug Delivery

Singh¹,

Gujral²

2015

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

View full text Add to dashboard Cite

Human health risk assessment of pharmaceuticals in the European Vecht River

Duarte

Oldenkamp

Ragas

2022

Integr Envir Assess & Manag

View full text Add to dashboard Cite

Active pharmaceutical ingredients (APIs) can reach surface waters used for drinking water extraction and recreational activities, such as swimming and fishing. The aim of the present study was to systematically assess the lifetime human health risks posed by 15 individual APIs and their mixtures occurring in the German-Dutch transboundary Vecht River. An exposure model was developed and used to assess the combined risks of oral and dermal exposure under a variety of exposure conditions. A total of 4500 API uptake values and 165 lifetime risk values were estimated for 15 and 11 APIs, respectively. Overall, the lifetime human health risks posed by the APIs and their mixtures based on modeling results were deemed acceptable under typical exposure conditions. Under very extreme environmental conditions and human behavior, API mixture risks were of potential concern while the risks of individual APIs were negligible, with a few exceptions. The antibiotic doxycycline and analgesic phenazone showed the highest and lowest risks, respectively. The study did not evaluate the potential risks caused by metabolite compounds. Recommendations for water managers are provided to help improve the accuracy and utility of human health risk assessments of pharmaceuticals.

show abstract

Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl analogues

Cited by 19 publications

References 6 publications

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Microporation for Enhanced Transdermal Drug Delivery

Human health risk assessment of pharmaceuticals in the European Vecht River

Contact Info

Product

Resources

About