Percutaneous CT-guided Cryoablation of the Dorsal Penile Nerve for Treatment of Symptomatic Premature Ejaculation

Prologo, J. David; Snyder, Laura; Cherullo, Edward E.; Passalacqua, Matthew; Pirasteh, Ali; Corn, David

doi:10.1016/j.jvir.2012.09.015

Cited by 30 publications

(28 citation statements)

References 15 publications

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“…Circumcised patients showed no significant changes in IELT or perceived control after surgery. Similar results have been produced by studies analyzing the effects of pulsed radiofrequency on the dorsal nerve, as well as computed tomography (CT)-guided cryoablation (3,4). …”

Section: Surgical Therapy Overviewsupporting

confidence: 72%

“…DNN is an invasive and irreversible procedure, and, to date, the longest studied time point is 6 months after surgery and 1 year after CT-guided cryoablation (2,4). One week after CT-guided cryoablation, the IELT jumped from 55 s at baseline to 256 s, but was only 56% of that value (146 s) after 1 year, demonstrating the importance of long-term follow-up (4). Pulsed radiofrequency neuroablation showed promising results, but patient outcomes were not monitored past 3 weeks of treatment (3).…”

Section: Surgical Therapy Overviewmentioning

confidence: 99%

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Surgery is not indicated for the treatment of premature ejaculation

Anaissie

Yafi

2016

Transl. Androl. Urol.

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Premature ejaculation (PE) is considered the most common male sexual disorder, affecting up to 75% of men at some point in their lives. While medical management is the mainstay of therapy, surgical options such as dorsal nerve neurectomy (DNN), hyaluronic acid (HA) gel glans penis augmentation, and circumcision have been studied as alternative forms of treatment. Preliminary studies have suggested that DNN and HA gel glans penis augmentation are relatively safe and effective, but due to a lack of large, multicenter, randomized-control trials with long-term follow-up, the International Society of Sexual Medicine (ISSM) has been unable to endorse DNN or HA gel glans penis augmentation as options in the treatment of PE. Conflicting data regarding the efficacy and safety of circumcision has similarly led to its exclusion from ISSM recommendations for the treatment of PE. Ethical concerns, particularly the fundamental concept of non-maleficence, are also barriers to the implementation of surgery for PE.

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Section: Surgical Therapy Overviewsupporting

confidence: 72%

Section: Surgical Therapy Overviewmentioning

confidence: 99%

Surgery is not indicated for the treatment of premature ejaculation

Anaissie

Yafi

2016

Transl. Androl. Urol.

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“…The mean IELT remained at 182.5 seconds±27.6 at day 180 (n=23; p<0.0001) and decreased to 140.9 seconds±83.6 by 1 year (n=22; p<0.001). They concluded that CT-guided percutaneous unilateral cryoablation of the nerves was a short and safe, single-day outpatient operation for the treatment of PE [6].…”

Section: Discussionmentioning

confidence: 99%

Quality of Sexual Life after Microsurgical Penile Denervation in Men with Primary Premature Ejaculation

Genov

Kolev

Kotsev

et al. 2017

Journal of Biomedical and Clinical Research

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SummaryPremature ejaculation (PE) is the most common sexual dysfunction in men, yet it is not well studied. Its frequency reaches 30% for men from 18 to 59 years of age in different countries. The aim of this article was to investigate the quality of sexual life in men with primary PE operated on with microsurgical penile denervation, using the Brief Male Sexual Functional Inventory (BMSFI). From September 2011 to March 2014, 22 patients were operated on with microsurgical penile denervation in the urology clinic of the University Hospital -Pleven and the Department of Urology at UMHAT Ruse AD. The mean result from the BMSFI in patients was 22 points preoperatively, indicating signi cant worsening of sexual function and quality of life in all ve questionnaire domains. After surgery, the results increased to 28, 33 and 39 respectively, at 3, 6 and 12 months, respectively. Premature ejaculation not only leads to problems in controlling ejaculation but also worsens the overall sexual function and quality of life of patients.

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“…Several other authors investigated the impact of ablation and modulation of the dorsal penile nerve [75,76]. Prologo et al [75] demonstrated that unilateral CT-guided percutaneous cryoablation of the dorsal penile nerve resulted in a significant increase in IELT and improved patient-reported outcome measures as well.…”

Section: Other Drugs and Treatmentsmentioning

confidence: 99%

“…Prologo et al [75] demonstrated that unilateral CT-guided percutaneous cryoablation of the dorsal penile nerve resulted in a significant increase in IELT and improved patient-reported outcome measures as well. Recently, Basal et al [76] assessed the role of percutaneous pulsed radiofrequency ablation of bilateral dorsal penile nerves in the treatment of premature ejaculation.…”

Section: Other Drugs and Treatmentsmentioning

confidence: 99%

Advances in treating premature ejaculation

Çayan

Şerefoğlu

2014

F1000Prime Rep

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In spite of its high prevalence and long history, the ambiguity regarding the definition, epidemiology and management of premature ejaculation continues. Topical anesthetic creams and daily or on-demand selective serotonin reuptake inhibitor (SSRI) treatment forms the basis of pharmacotherapy for premature ejaculation today, in spite of low adherence by patients. Psychotherapy may improve the outcomes when combined with these treatment modalities. Tramadol and phosphodiesterase type 5 inhibitors have a limited role in the management of premature ejaculation. Further research is required to develop better options for the treatment of this common sexual disorder.

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Percutaneous CT-guided Cryoablation of the Dorsal Penile Nerve for Treatment of Symptomatic Premature Ejaculation

Cited by 30 publications

References 15 publications

Surgery is not indicated for the treatment of premature ejaculation

Surgery is not indicated for the treatment of premature ejaculation

Quality of Sexual Life after Microsurgical Penile Denervation in Men with Primary Premature Ejaculation

Advances in treating premature ejaculation

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