Percutaneous CT-fluoroscopic–guided radioisotope seed placement for the management of adenoid cystic carcinoma of the trachea

Doggett, Stephen; Chino, Shigeru; Lempert, Todd E.; Federhart, Jay

doi:10.1016/j.brachy.2016.11.007

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Tracheal ACCs were reported to be treated with a high dose of permanent Palladium-103 seed implantation under CT guidance ( 7 ). The three patients were followed for an average time of nine months, when they showed disease regression and symptom improvement.…”

Section: Discussionmentioning

confidence: 99%

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Ke¹,

Zeng²,

Chen³

et al. 2023

Front. Oncol.

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Adenoid cystic carcinoma (ACC) of central airway is very rare. More than half of ACCs are unresectable for tumor extension. There’s rare report on local ACCs only in central airway. We present a case of ACC in central airway who underwent an innovative brachytherapy. A 44-year-old woman was diagnosed with primary ACC in central airway without regional lymphadenopathy or metastatic disease. Stenosis was observed in lower trachea and both left and right main bronchi (stenosis in lumen ≥50%) with bronchoscopy. The tumor was unresectable due to local extension. A Y-shaped and stainless-steel stent loaded with radioactive 125I seeds was placed in the central airway using bronchoscope. The number and distribution of 125I seeds were planed using treatment planning system. The stent was removed three months later. The patient tolerated the procedure well. She was alive without relapse three years after removing the stent with 125I seeds. This case demonstrates the successful use of stent with radioactive 125I seeds for unresectable ACCs in central airway. In the procedure, the stent was placed with bronchoscope and under the vision from bronchoscope. This innovative brachytherapy is well-tolerated, safe, precise and individualized designed. The patient with unresectable ACCs could get a long-term relapse-free survival. Clinical trials could be taken to validate its effectiveness and tolerability in patients with ACCs of central airway.

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Section: Discussionmentioning

confidence: 99%

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Ke¹,

Zeng²,

Chen³

et al. 2023

Front. Oncol.

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“…Though some other forms of treatment such as new types of radiotherapy and endoscopic resection (10,11) have been invented and practiced, their long-term outcomes compared with that of traditional resection remains unclear because of its low morbidity. Currently, Doggett S et al have reported that 3 patients with tracheal ACC were implanted with 103 Pd under CT-fluoroscopic guidance utilizing percutaneous approach and responded well in the short-term with no chronic side effects (12). Therefore, more comparing studies should be encouraged to apply evidence for decision making.…”

Section: Discussionmentioning

confidence: 99%

3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report

Feng

Liu

et al. 2018

J. Thorac. Dis.

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Complete resection remains the ideal treatment for most patients with primary intratracheal tumors. Due to the limit in the resection length, the localization of the tumor during the surgery could be rather difficult if it hasn't invaded out of the trachea, which might be more difficult when there's another tumor in the anterior mediastinum. A 26-year-old woman with intratracheal adenoid cystic carcinoma (ACC) presented with dyspnea. CT scan revealed not only an ACC without extension out of trachea, but also a mediastinal teratoma (MT) near aorta, making the operation much more complicated than usual. To solve this problem, 3D-printing was applied for facilitating surgery plan making and intraoperative locating of ACC. And as we expected, the operation went successfully and the patient achieved full recovery without complications. To the best of our knowledge, the case of both intratracheal ACC and MT in one patient has not been previously reported.

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“…In 1991, our group was the first in the world to perform CTGPSB [6]. Our technique has been presented previously and has been described in detail [6,7,8,9]. Permanent seed brachytherapy utilizes low energy radioisotope sources (22 KeV 103 Pd, 35.5 Kev iodine-125 [ 125 I]) encased in a tiny titanium tube.…”

Section: Purposementioning

confidence: 99%

A novel approach for salvage treatment of non-small-cell lung cancer: percutaneous CT fluoroscopy-guided permanent seed brachytherapy for salvage treatment of lung cancer: long-term results of a case series

Doggett

Chino

Lempert

2019

jcb

Self Cite

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Purpose We sought a curative technique to treat recurrent or primary non-small cell lung cancer (NSCLC) with a minimally invasive outpatient technique that could be repeated multiple times, had minimal pulmonary toxicity, and was readily available in the community setting. Percutaneous outpatient computed tomography (CT) fluoroscopy-guided permanent seed brachytherapy fits these criteria. Material and methods Eight lesions in five patients (three patients had two lesions each) with NSCLC were treated using outpatient percutaneous CT fluoroscopy-guided palladium-103 seed brachytherapy. At initial presentation, seven lesions had recurred following external beam radiation therapy (EBRT) and initial chemotherapy, and one lesion was treated with brachytherapy as a primary treatment. Results In five patients with eight lesions, there were no recurrences at follow-up from final implant, average follow-up of 58.1 months (range, 15-145 months). There were no acute complications requiring intervention and no long-term complications. One lesion required a second salvage implant 10 months after first implant. This lesion’s original salvage D 90 was but 90% and repeat implant achieved a D 90 of 273%. This salvaged site had not recurred at 43-month follow-up after the second salvage implant. Conclusions Percutaneous CT fluoroscopy-guided permanent seed brachytherapy is a safe, efficacious, and cost effective primary and salvage treatment for lung cancer. CT-fluoroscopy resources are readily available in the community and are an effective alternative to stereotactic body radiation therapy (SBRT), intensity-modulated radiation therapy (IMRT)/proton beam, radiofrequency ablation (RFA), and cryoablation (CA). Percutaneous CT fluoroscopy-guided permanent seed brachytherapy has an equivalent or better local control rate, a lower resource cost, and a far lower integral radiation dose than other therapies. We believe this is the first published article documenting the curative potential of percutaneous CT fluoroscopy-guided permanent seed brachytherapy for recurrent NSCLC with long-term follow-up. High D 90 doses appear to be required to achieve complete response. Further studies are essential to confirm these findings.

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Percutaneous CT-fluoroscopic–guided radioisotope seed placement for the management of adenoid cystic carcinoma of the trachea

Cited by 5 publications

References 19 publications

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report

A novel approach for salvage treatment of non-small-cell lung cancer: percutaneous CT fluoroscopy-guided permanent seed brachytherapy for salvage treatment of lung cancer: long-term results of a case series

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