Percutaneous closure of interatrial communications in adults – prospective embolism prevention study with two- and three-dimensional echocardiography

Abstract

Background: Patients with interatrial communications after paradoxical embolic events are at risk for recurrent thromboembolism. We hypothesized that transcatheter closure of the defects would result in long-term prevention of systemic embolism and performed clinical and echocardiographic follow-up.

Percutaneous Interventional Treatment of Atrial Septal Defect Secundum in Macedonia

“…One study of 1000 patients showed that the incidence of thrombus formation is 1, 2% and usually forms between the fourth and the sixth week after the procedure. Risk factors are AF episodes, incomplete endotelialization of the device, non-compliance with therapy and hypercoagulability states and medication resistance [30][31][32][33][34][35]. In our series, all of the patients received Aspirin 5-10 mg/kg daily and 85% of adults received double antithrombotic therapy with aspirin 100 mg/day and clopidogrel 75 mg/day.…”

The Simultaneous Occurrence of Deep Vein Thrombosis and Pulmonary and Arterial Embolization

“…In addition, she may have an underlying hypercoagulable state, as suggested by abnormalities in her hospital laboratory studies. Even if these abnormalities are not confirmed, many would argue that this patient with a known PFO and a large paradoxical embolus should be on life-long anticoagulation unless the PFO is closed 4,5 . A finding of a hypercoagulable state might have implication for thromboembolism prophylaxis for family members, however.…”

Transesophageal Real-Time Three-Dimensional Echocardiography

“…Transesophageal real-time 3D echocardiography could thus become an important supplement to imaging in electrophysiology. It would also be a valuable procedure for controlling the intervention in percutaneous implantations of ASD occluders or cardiac valves (12)(13)(14). The development of new surgical procedures in the future should enable operations like ASD occlusion or mitral valve repair on the beating heart under 3D echocardiographic control.…”