Percutaneous Autologous Bone Marrow Injection in the Treatment of Distal Meta-diaphyseal Tibial Nonunions and Delayed Unions

Braly, Houston L.; O’Connor, Daniel P.; Brinker, Mark R.

doi:10.1097/bot.0b013e31828bf077

Cited by 55 publications

(43 citation statements)

References 31 publications

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“…Treatments involving the use of stem cells [38][39][40][41][42] , bone-marrow-aspirate preparations 43 , and progenitor cells [44][45][46] (e.g., endothelial progenitor cells, periosteal progenitor cells) are emerging as clinical applications.…”

Section: Progenitor Cells and Growth Factorsmentioning

confidence: 99%

The Biological Basis for Nonunions

Brinker

O’Connor

2016

JBJS Rev

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Fracture nonunion is a failure of the biological processes of fracture-healing. Critical cellular events in fracture-healing include the inflammatory response, differentiation and proliferation of progenitor cells, formation of fibrocartilage callus, angiogenesis and subsequent mineralization of the callus, vascular union (restoration of normal medullary circulation), and conversion of woven bone to lamellar bone. All critical events are closely regulated and coordinated by numerous cytokines and growth factors, which are expressed in complex spatial and temporal patterns throughout the repair process. At all phases of fracture-healing, poor cellular and metabolic capacity (e.g., chronic disease), excessive instability, and poor vascularity inhibit cellular responses and healing. Many biological treatments to prevent or treat nonunions are emerging in clinical use, including stem-cell and bone-marrow-aspirate preparations, various progenitor cells and growth factors (e.g., recombinant human bone morphogenetic proteins), and gene therapy.

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Section: Progenitor Cells and Growth Factorsmentioning

confidence: 99%

The Biological Basis for Nonunions

Brinker

O’Connor

2016

JBJS Rev

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“…2 We are unable however to understand how his opinions are related to the treatment approach and the data showing its effectiveness as presented in our article. 2 We are unable however to understand how his opinions are related to the treatment approach and the data showing its effectiveness as presented in our article.…”

Section: To the Editormentioning

confidence: 81%

To the Editor

Brinker¹,

O’Connor²

2014

Journal of Orthopaedic Trauma

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“…Recently, many clinical trials have been performed on the treatment of nonunion or delayed union with bone marrow or bone marrow cultures, including osteoprogenitor cells that differentiate into osteoblasts [Hernigou et al, 2005;Kim et al, 2009;Gomez-Barrena et al, 2011;Braly et al, 2013;Guimaraes et al, 2014;Le Nail et al, 2014;Sugaya et al, 2014;Hernigou et al, 2016]. As nonunion or delayed union is caused by multiple complicated factors, the strategy of reducing their incidence or preventing their occurrence merely by addressing the issues related to physicians' techniques will only be partially successful [Herscovici et al, 2000].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

Park

Shetty

Kim

et al. 2017

Cells Tissues Organs

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We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

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Percutaneous Autologous Bone Marrow Injection in the Treatment of Distal Meta-diaphyseal Tibial Nonunions and Delayed Unions

Abstract: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Cited by 55 publications

References 31 publications

The Biological Basis for Nonunions

The Biological Basis for Nonunions

To the Editor

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

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