Percutaneous absorption of interferon-α by self-dissolving micropiles

Ito, Yoshiaki; Saeki, Atsushi; Shiroyama, K; Sugioka, Nobuyuki; Takada, Kanji

doi:10.1080/10611860801902575

Cited by 34 publications

(11 citation statements)

References 27 publications

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“…Examples of cytokines bound to GAGs in a steady state include binding of HS to , limiting the extent of its C-terminal domain degradation (61), yet decreasing the plasma clearance and increasing the cytokine activity by up to 600% (62). In addition, a pharmacokinetic study substantiated the in vivo long-lasting characteristics of GAG-containing IFN-g formulations (63). It has previously been shown that IL-8-GAG interactions facilitate binding of the cytokine to its specific receptor, prolong IL-8 activity, and protect it from proteolysis (13).…”

Section: Discussionmentioning

confidence: 81%

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Reeves

Williamson

Byrne

et al. 2009

The Journal of Immunology

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Dysregulation of airway inflammation contributes to lung disease in cystic fibrosis (CF). Inflammation is mediated by inflammatory cytokines, including IL-8, which illustrates an increase in biological half-life and proinflammatory activity when bound to glycosaminoglycans (GAGs). The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Bronchoalveolar lavage fluid was collected from patients with CF (n = 28), non-CF controls (n = 14), and patients with chronic obstructive pulmonary disease (n = 12). Increased levels of IL-8 and reduced concentrations of IL-18 were detected in bronchial samples obtained from CF individuals. The low level of IL-18 was not a defect in IL-18 production, as the pro- and mature forms of the molecule were expressed and produced by CF epithelial cells and monocytes. There was, however, a marked competition between IL-8 and IL-18 for binding to GAGs. A pronounced loss of IL-18 binding capacity occurred in the presence of IL-8, which displaced IL-18 from these anionic-matrices, rendering the cytokine susceptible to proteolytic degradation by neutrophil elastase. As a biological consequence of IL-18 degradation, reduced levels of IL-2 were secreted by Jurkat T lymphocytes. In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung.

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Section: Discussionmentioning

confidence: 81%

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Reeves

Williamson

Byrne

et al. 2009

The Journal of Immunology

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“…Furthermore, high BAs of 87.5% were obtained for rhGH in rats (30) and of 82.1-99.4% for erythropoietin (EPO) in mice (31). The relative BA of interferon (IFN) against subcutaneous injection of IFN solution was 79.9-117.8% in rats (32). Relative PA of insulin was 90-99% in dogs (33).…”

Section: Introductionmentioning

confidence: 94%

Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats

et al. 2010

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“…16 The relative BA of interferon against subcutaneous injection was 79.9%-117.8% in rats. 17 Relative pharmacological availability of insulin was 90%-99% in dogs. 18 These protein drugs have MW of less than 2.5 kDa.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lipophilicity on the Bioavailability of Drugs After Percutaneous Administration by Dissolving Microneedles

Ito

Yoshimura

Tanaka

et al. 2012

Journal of Pharmaceutical Sciences

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Percutaneous absorption of interferon-α by self-dissolving micropiles

Cited by 34 publications

References 27 publications

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats

Effect of Lipophilicity on the Bioavailability of Drugs After Percutaneous Administration by Dissolving Microneedles

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