Percutaneous Absorption Enhancement by Nonionic Surfactants

Sarpotdar, Pramod P.; Zatz, Joel L.

doi:10.3109/03639048609042599

Cited by 54 publications

(19 citation statements)

References 3 publications

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“…These results are in accordance with the previous findings which demonstrate better skin permeability of drug through topical niosomal formulations [8]. Surfactants in formulations serve as penetration enhancer by raising the fluidity and reducing the barrier property of stratum corneum [20,21].…”

Section: In Vitro Skin Permeation and Deposition Studiessupporting

confidence: 94%

“…Surfactants in formulations serve as penetration enhancer by enhancing the fluidity and reducing the barrier property of stratum corneum [19,20,28]. Moreover, the principle constitutive lipid of niosomes (span 85) is composed of unsaturated fatty acids (trioleate chains) and the presence of unsaturated fatty acids in the lipids facilitated the skin permeation of bioactive due to change in fluidity of stratum corneum lipid structure caused by the packing nature of unsaturated fatty acids [20,29].…”

Section: Immunological Responsementioning

confidence: 99%

“…Moreover, the principle constitutive lipid of niosomes (span 85) is composed of unsaturated fatty acids (trioleate chains) and the presence of unsaturated fatty acids in the lipids facilitated the skin permeation of bioactive due to change in fluidity of stratum corneum lipid structure caused by the packing nature of unsaturated fatty acids [20,29]. Moreover, hepatitis B surface antigen Antibody titers are expressed as log mIU/ml (mean ± SD).…”

Section: Immunological Responsementioning

confidence: 99%

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Non-ionic surfactant vesicles mediated transcutaneous immunization against hepatitis B

Maheshwari

Pandey

Chaurasiya

et al. 2011

International Immunopharmacology

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Section: In Vitro Skin Permeation and Deposition Studiessupporting

confidence: 94%

Section: Immunological Responsementioning

confidence: 99%

Section: Immunological Responsementioning

confidence: 99%

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Non-ionic surfactant vesicles mediated transcutaneous immunization against hepatitis B

Maheshwari

Pandey

Chaurasiya

et al. 2011

International Immunopharmacology

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“…8 too large to diffuse into the skin layers. 7,25) Therefore direct contact and adherence of the vesicles with skin surface is important for the drug to penetrate and partition between the stratum corneum and the formulation. 26) Surface tension values will give us idea of the extent of the contact of the drugloaded vesicle with the skin surface.…”

Section: Solubility and Surface Tensionmentioning

confidence: 99%

Transdermal Delivery of Haloperidol by Proniosomal Formulations with Non-ionic Surfactants

Azarbayjani

Tan

Chan

et al. 2009

Biological & Pharmaceutical Bulletin

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Proniosomal formulations with non-ionic surfactant were studied. The effect of hydrophilicity and hydrophobicity of one or two surfactants on drug solubility, proniosome surface structure and stability and skin permeation of haloperidol from different formulations were investigated. Haloperidol (HP) was entrapped in proniosomes with very high efficiency for all formulations. Stability studies performed at 4 degrees C and 25 degrees C for a period of 6 weeks did not reveal any significant drug leakage (p>0.05). Formulations with single surfactants were found to increase the skin permeation of HP more than formulations containing two surfactants. The number of carbons in the alkyl chain of the non-ionic surfactant influenced the in vitro permeation of HP though the epidermis and the skin permeation was increased with increase in hydrophilic-lipophilic balance (HLB) value of the surfactant. Interfacial tension and surfactant hydrophobicity appeared to be useful for elucidating mechanism of skin permeation and for comparing drug fluxes from different proniosomal formulations.

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“…Microemulsion systems are generally designed for topic (skin, dermal) drug delivery [39][40][41][42]. The use of non-ionic microemulsions as enhancers for transdermal drug delivery of lidocaine has been studied by Sarpotdar and Zatz [43].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Adding Drug (Lidocaine) to a Drug Delivery System Using Small-Angle X-Ray Scattering

Balogh

Pedersen

Colloids for Nano- And Biotechnology

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The effect on a model drug delivery system when adding a drug, lidocaine, has been studied. Temperature and concentration dependence of a nonionic microemulsion with part of the oil, 1 and 10 vol. %, substituted with drug has been investigated. A nonionic oilin-water microemulsion consisting of CH 3 (CH 2 ) 11 (OCH 2 CH 2 ) 5 OH, (C 12 E 5 ), decane, water and the drug (lidocaine) that has been used to substitute part of the oil was studied. The microscopic differences have been derived from smallangle X-ray scattering (SAXS) data and the results are compared with light scattering data. Using these results together with the macroscopic differences, as observed in the phase diagram (lowering of phase boundaries), between the systems with and without lidocaine can be explained.

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Percutaneous Absorption Enhancement by Nonionic Surfactants

Cited by 54 publications

References 3 publications

Non-ionic surfactant vesicles mediated transcutaneous immunization against hepatitis B

Non-ionic surfactant vesicles mediated transcutaneous immunization against hepatitis B

Transdermal Delivery of Haloperidol by Proniosomal Formulations with Non-ionic Surfactants

Investigating the Effect of Adding Drug (Lidocaine) to a Drug Delivery System Using Small-Angle X-Ray Scattering

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