Percutaneous absorption and the surface area of occluded skin.

Infectious dermatoses in adult diabetic patients

“…The reason of the low occurrence of tinea pedis is, perhaps, the habitual wearing of open wetl-ventilated types of footware. The increased sweating and hydration of the skin brought by occlusive foot wear is thought to have a role in the common occurrence of tinea pedis in the western world [10,11]. This may also be the reason for the low prevalence of toe web erythrasma in our study compared to that (44%) reported by Somerville and Lancaster-Smith [6].…”

Photodynamic therapy for acne vulgaris: A critical review from basics to clinical practice

“…Occlusion is known to reduce transepidermal water loss, hydrating the stratum corneum and generally enhancing drug penetration, especially for hydrophilic molecules such as ALA. 43,44 Of the 18 publications, 10 recommended occlusion for their patients during drug incubation. [12][13][14]18,23,[39][40][41][42] Of note, the desired route of ALA or MAL uptake for acne therapy may be directly into hair follicles rather than through the stratum corneum.…”

Etude comparée de la perte insensible d’eau et de la pénétration cutanée des corticoïdes

“…L'occlusion favorise l'hydratation de la couche cornée, la fait donc gonfler et augmente sa surface [11], L'efficacité de la fonction barrière du stratum corneum est donc diminuée. Ces modifications sont transitoires, la PIE revient à la normale en 40-60 min après une occlusion de courte durée [17].…”