Perceptually or conceptually driven recognition: On the specificities of the memory deficit in schizophrenia

Guillaume, Fabrice; Thomas, Émilie; Faget, Catherine; Richieri, Raphaëlle; Lançon, Christophe

doi:10.1016/j.psychres.2014.11.060

Cited by 7 publications

(6 citation statements)

References 79 publications

(113 reference statements)

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“…Other researchers proposed a similar reasoning to account for the lower FR of patients with Alzheimer's disease (Budson, Daffner, Desikan, & Schacter, 2000;Budson et al, 2002) and Korsakoff amnesia (Schacter et al, 1998). Brain activity differences observed in the current study therefore provide a significant contribution to the understanding of schizophrenia patients' capacity to correctly reject items similar to those that were previously studied (Moritz et al, 2008;Guillaume et al, 2015). For instance, in Moritz et al (2008), differences in CR and FR between schizophrenia participants and healthy controls disappeared in the condition where lures were sharing several characteristics with the studied items.…”

Section: Discussionsupporting

confidence: 68%

“…The study of Moritz et al (2008) is critical because it showed abnormal recollection rejection when lures were easily distinguished from the studied items, but not when the discrimination was difficult. Guillaume, Thomas, Faget, Richieri, and and Lançon (2015) recently replicated this finding. They used lures that were very similar to studied objects, and did not observe any differences between patients with schizophrenia and healthy controls for the CR rate of the lures.…”

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confidence: 71%

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Recollection rejection of new items in individuals with first-episode psychosis.

Guimond

Lepage

Benoit

et al. 2016

Journal of Abnormal Psychology

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Many objects seen for the first time look familiar because they resemble known objects. To overcome this feeling of familiarity and detect novelty, memories of known objects must be recollected and compared to new objects. This experiment examines whether recollection performed when perceiving new items (i.e., recollection rejection) is abnormal in people who experienced a first episode of psychosis (FEP). Recollection of old items is impaired in this clinical population but it has not yet been demonstrated that this impairment influences the processing of new items. Eighteen FEP participants and 19 healthy controls completed an episodic memory task consisting of a study phase and a recognition phase. All the new objects looked familiar because they resembled the studied objects. Brain activity underlying false recognition and correct rejection of new objects was measured with functional resonance magnetic imaging and compared across groups. Behavioral responses to new items were not significantly different between the 2 groups. However, the between-groups analysis revealed significant differences in brain activity in the left middle frontal gyrus, the left inferior parietal lobule, the right superior parietal lobule, and the right temporal fusiform gyrus during the correct rejection of new items. This activity seems related to recollection rejection and suggests that FEP patients do not normally recollect information of past events when they process new items.

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Section: Discussionsupporting

confidence: 68%

mentioning

confidence: 71%

Recollection rejection of new items in individuals with first-episode psychosis.

Guimond

Lepage

Benoit

et al. 2016

Journal of Abnormal Psychology

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“…The hippocampus plays a pivotal role in context discrimination functions, including those necessary for fear learning (Frankland et al, 1998; McDonald et al, 2004) (Frohardt et al, 1999; Holt and Maren, 1999; Quintero et al, 2011; Young et al, 1995). Schizophrenia is a complex psychiatric disorder with known hippocampal dysfunction and context discrimination deficits (Benes, 2015; Guillaume et al, 2015; MacDonald et al, 2005; MacDonald et al, 2003; Schobel et al, 2013; Schobel et al, 2009a; Schobel et al, 2009b; Servan-Schreiber et al, 1996; Siever et al, 2002; Talamini and Meeter, 2009), such as inappropriate memory generalization or an inability to ignore irrelevant stimuli (Gal et al, 2005; Ivleva et al, 2012; Jazbec et al, 2007; Racsmany et al, 2008; Roiser et al, 2009; Shohamy et al, 2010; Warren and Haslam, 2007). Patients are also unable to modulate hippocampal activation during recognition memory, especially in response to novel stimuli (Ivleva et al, 2012; Schott et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Impaired contextual fear-conditioning in MAM rodent model of schizophrenia

Gill

Grace

2018

Schizophrenia Research

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The methylazoxymethanol acetate (MAM) rodent neurodevelopmental model of schizophrenia exhibits aberrant dopamine system activation attributed to hippocampal dysfunction. Context discrimination is a component of numerous behavioral and cognitive functions and relies on intact hippocampal processing. The present study explored context processing behaviors, along with dopamine system activation, during fear learning in the MAM model. Male offspring of dams treated with MAM (20mg/kg, i.p.) or saline on gestational day 17 were used for electrophysiological and behavioral experiments. Animals were tested on the immediate shock fear conditioning paradigm, with either different pre-conditioning contexts or varying amounts of context pre-exposure (0-10 sessions). Amphetamine-induced locomotor activity and dopamine neural activity was measured 1-week after fear conditioning. Saline, but not MAM animals, demonstrated enhanced fear responses following a single context pre-exposure in the conditioning context. One week following fear learning, saline rats with 2 or 7min of context pre-exposure prior to fear conditioning also demonstrated enhanced amphetamine-induced locomotor response relative to MAM animals. Dopamine neuron recordings showed fear learning-induced reductions in spontaneous dopamine neural activity in MAM rats that was further reduced by amphetamine. Apomorphine administration confirmed that reductions in dopamine neuron activity in MAM animals resulted from over excitation, or depolarization block. These data show a behavioral insensitivity to contextual stimuli in MAM rats that coincide with a less dynamic dopamine response after fear learning.

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“…Results showed that participants with autism had explicit memory difficulties as they could not retrieve the objects' locations, but could remember them unconsciously, as implicit memory performance was unaffected. Among a sample of participants with schizophrenia that had to remember pictures of daily-use objects, the performance was better in the inclusion task, but implicit and explicit memory process were both impaired (Guillaume et al, 2015). In a study with Parkinson disease participants that had to learn pictures, Pitarque et al (2017) pointed out that implicit memory is preserved, while explicit memory is impaired.…”

Section: Overview Of the Current Researchmentioning

confidence: 99%

“…Recently, the Process Dissociation procedure was used among various samples of clinical populations such as autism (Ring, Gaigg, & Bowler, 2015), schizophrenia (Guillaume, Thomas, Faget, Richieri, & Lançon, 2015), Parkinson disease (Pitarque et al, 2017), Alzheimer disease (Kessels, Feijen, & Postma, 2005), as well as in healthy ageing (Koen & Yonelinas, 2016). In a computerized task, healthy controls and participants with autism had to study pictures of rooms and the location of objects and then to perform an object location and object recognition task.…”

Section: Overview Of the Current Researchmentioning

confidence: 99%

The Effect of Learning in a Virtual Environment on Explicit and Implicit Memory by Applying a Process Dissociation Procedure

Voinescu

David

2018

International Journal of Human–Computer Interaction

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Virtual reality-based neuropsychological assessment has unique features that have the potential to increase the level of ecological validity of test results. Based on findings from the literature on the task difficulty of cognitive tasks embedded into virtual environments, we aimed to explore the task difficulty hypothesis of virtual reality in memory assessment. Our main objective was to test for differences or equivalences between performance on explicit and on implicit memory tasks in three learning environments: a computerized measure, a 3D desktop environment and a 3D virtual environment. Seventy-seven healthy participants, aged between 19 and 39 years old, enrolled in the study and were randomly assigned to the learning conditions and responded to typical virtual reality measures. Outcomes of explicit and implicit memory resulted after applying Process Dissociation Procedure. One-way ANOVA did not reveal a significant main effect of learning environment on explicit memory performance and equivalence testing showed similar performance on implicit memory across the learning conditions. In our study, both controlled and automatic memory processes were not influenced by the learning environment.

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Perceptually or conceptually driven recognition: On the specificities of the memory deficit in schizophrenia

Cited by 7 publications

References 79 publications

Recollection rejection of new items in individuals with first-episode psychosis.

Recollection rejection of new items in individuals with first-episode psychosis.

Impaired contextual fear-conditioning in MAM rodent model of schizophrenia

The Effect of Learning in a Virtual Environment on Explicit and Implicit Memory by Applying a Process Dissociation Procedure

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