Perceptual distortion of the tongue by lingual nerve block and topical application of capsaicin in healthy women

Honda, Mika; Iida, Takashi; Dagsdóttir, Lilja K.; Komiyama, Osamu; Kawara, Misao; Svensson, Peter

doi:10.1007/s00784-016-1994-x

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…Honda et al [72] examined reports of perceptual distortion evoked by transient deafferentation and burning pain as models of aspects of BMS. Healthy women took part in three experimental sessions that included exposure to a lingual nerve block, capsaicin, and a control substance.…”

Section: Other Neurophysiological Studiesmentioning

confidence: 99%

Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review

Orliaguet

Miséry

2021

Biomolecules

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The pathophysiology of primary burning mouth syndrome (BMS) has been extensively debated but is poorly understood despite a large number of hypotheses attempting to explain its etiopathogenic mechanisms. The aim of the present work was to systematically review papers that could provide arguments in favour of the neuropathic and psychogenic components of primary BMS for a better understanding of the disease. This systematic review (SR) was registered in PROSPERO (CRD42021224160). The search was limited to articles in English or French from 1990 to 01 December 2020. A total of 113 articles were considered for data extraction. We divided them into four subgroups: pharmacological and nonpharmacological management studies (n = 23); neurophysiological studies (n = 35); biohistopathological studies (n = 25); and questionnaire-based studies (n = 30). Several of these studies have shown neuropathic involvement at various levels of the neuraxis in BMS with the contribution of quantitative sensory testing (QST), functional brain imaging, and biohistopathological or pharmacologic studies. On the other hand, the role of psychological factors in BMS has also been the focus of several studies and has shown a link with psychiatric disorders such as anxiety and/or depression symptoms. Depending on the patient, the neuropathic and psychogenic components may exist simultaneously, with a preponderance of one or the other, or exist individually. These two components cannot be dissociated to define BMS. Consequently, BMS may be considered nociplastic pain.

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Section: Other Neurophysiological Studiesmentioning

confidence: 99%

Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review

Orliaguet

Miséry

2021

Biomolecules

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“…Perceptual distortion (PD) is a form of disorder in the way one experiences one's own body in terms of size and shape. Descriptions of such distortion are commonly encountered in the dental clinic due to peripheral sensory deprivation of the region with local anaesthetics (LA) . Furthermore, distortion of corporal awareness has been documented for patients suffering from various psychological and neurological conditions, accounting non‐painful such as phantom sensations and anorexia nervosa, and painful conditions such as oro‐facial pain, complex regional pain syndrome and phantom limb pain .…”

Section: Introductionmentioning

confidence: 99%

Multisensory modulation of experimentally evoked perceptual distortion of the face

Dagsdóttir

Bellan

Skyt

et al. 2017

J of Oral Rehabilitation

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“…The main reason for the observed differences in the results could be the methodological differences between the two studies. While Farah et al (2023) exposed the whole oral mucosa to capsaicin by using a 5 ppm capsaicin rinse, in our study capsaicin was only applied to the tip of the tongue (Gøkhan et al, 2023; Honda, Baad‐Hansen, Iida, Dagsdóttir, et al, 2017; Honda, Baad‐Hansen, Iida, Komiyama, et al, 2017). A study conducted by Wang et al (2011) has shown differences in the expression of TRPV1‐receptors in the tongue, palate, and buccal mucosa of rats.…”

Section: Discussionmentioning

confidence: 90%

Do milk proteins relieve capsaicin‐induced burning sensation in the oral cavity?

Gøkhan,

Sørensen,

Baad‐Hansen

2024

Journal of Sensory Studies

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Milk has a soothing effect on the capsaicin‐induced burning sensation in the mouth. This double‐blinded, placebo‐controlled, cross‐over study aimed to investigate if milk proteins could relieve the capsaicin‐induced burning sensation. During each session, the tongue of each participant was exposed to capsaicin twice for 8 min in total. Subsequently, the participants rinsed the mouth with one of three solutions: 5% casein, 5% whey protein, or water. The participants rated the perceived unpleasantness and burning sensation during capsaicin exposure and after rinsing on numerical rating scales. Thermographic imaging and semi‐quantitative sensory testing were performed at baseline, after capsaicin exposure, and after rinsing. No significant differences were observed between sessions in any of the measured parameters (p ≥ .053). Scores for unpleasantness and burning sensation varied over time (p ≤ .006). Heat and mechanical sensitivity changed over time (p < .001). In conclusion, rinsing with milk protein solutions did not have any robust effect in this study design.Practical ApplicationsIt has been suggested that milk proteins could be responsible for the soothing effect milk has on the capsaicin‐induced burning sensation in the mouth. The present results indicate that milk proteins are not solely responsible for this effect. Shedding light on the effects milk and its constituents have on the oral mucosa during a state of burning sensation or pain is of importance. This can help determining if specific constituents of milk could be used to relieve meal‐related burning sensations as well as illness‐related acute or chronic pain in the oral mucosa.

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Perceptual distortion of the tongue by lingual nerve block and topical application of capsaicin in healthy women

Abstract: The perceptual distortion of the tongue was investigated with models of aspects of BMS and may have implications for future studies in clinical populations.

Cited by 8 publications

References 24 publications

Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review

Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review

Multisensory modulation of experimentally evoked perceptual distortion of the face

Do milk proteins relieve capsaicin‐induced burning sensation in the oral cavity?

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