Perceptual characteristics of Parkinsonian speech: A comparison of the pharmacological effects of levodopa across speech and non-speech motor systems

Plowman-Prine, Emily K.; Okun, Michael S.; Sapienza, Christine M.; Shrivastav, Rahul; Fernández, Hubert H.; Foote, Kelly D.; Ellis, Charles; Rodriguez, Amy D.; Burkhead, Lori M.; Rosenbek, John C.

doi:10.3233/nre-2009-0462

Cited by 83 publications

(63 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to sensorimotor impairments, cranial sensorimotor deficits were also detected in this model using USV recording and analysis methods [44,49] Rodents produce USVs, which are analogous to human vocalizations in several ways including serving a communicative function [50-53] and being produced via aggressive airflow through the larynx [54,55] In PD, dysarthria, which includes vocal deficits such as reduced loudness and pitch variability, and a vocal tremor [56], are common and can severely impact the quality of life for patients by impairing communication [57]. USV deficits in the classic 6-hydroxydopmine model of PD are reminiscent of the voice deficits observed in patients [44,49].…”

Section: Discussionmentioning

confidence: 99%

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

et al. 2013

View full text Add to dashboard Cite

The discovery of the involvement of alpha-synuclein (α-syn) in Parkinson’s disease (PD) pathogenesis has resulted in the development and use of viral vector-mediated α-syn overexpression rodent models. The goal of these series of experiments was to characterize the neurodegeneration and functional deficits resulting from injection of recombinant adeno-associated virus (rAAV) serotype 2/5-expressing human wildtype α-syn in the rat substantia nigra (SN). Rats were unilaterally injected into two sites in the SN with either rAAV2/5-expressing green fluorescent protein (GFP, 1.2 x 1013) or varying titers (2.2 x 1012, 1.0 x 1013, 5.9 x 1013, or 1.0 x 1014) of rAAV2/5-α-syn. Cohorts of rats were euthanized 4, 8, or 12 weeks following vector injection. The severity of tyrosine hydroxylase immunoreactive (THir) neuron death in the SN pars compacta (SNpc) was dependent on vector titer. An identical magnitude of nigrostriatal degeneration (60-70% SNpc THir neuron degeneration and 40-50% loss of striatal TH expression) was observed four weeks following 1.0 x 1014 titer rAAV2/5-α-syn injection and 8 weeks following 1.0 x 1013 titer rAAV2/5-α-syn injection. THir neuron degeneration was relatively uniform throughout the rostral-caudal axis of the SNpc. Despite equivalent nigrostriatal degeneration between the 1.0 x 1013 and 1.0 x 1014 rAAV2/5-α-syn groups, functional impairment in the cylinder test and the adjusting steps task was only observed in rats with the longer 8 week duration of α-syn expression. Motor impairment in the cylinder task was highly correlated to striatal TH loss. Further, 8 weeks following 5.9 x 1013 rAAV2/5-α-syn injection deficits in ultrasonic vocalizations were observed. In conclusion, our rAAV2/5-α-syn overexpression model demonstrates robust nigrostriatal α-syn overexpression, induces significant nigrostriatal degeneration that is both vector and duration dependent and under specific parameters can result in motor impairment that directly relates to the level of striatal TH denervation.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

et al. 2013

View full text Add to dashboard Cite

show abstract

“…We have recently examined the differential effects of levodopa medications on speech motor vs. limb motor function in sixteen individuals with idiopathic PD (Plowman-Prine, Okun, et al, 2009). Specific aims were to: (a) examine the effects of levodopa on 35 perceptual speech dimensions grouped into seven speech-sign clusters and (b) compare the relative effectiveness of levodopa on global motor functioning vs. speech production.…”

Section: Cranial Motor Vs Limb Motor Dysfunction In Parkinson's Dmentioning

confidence: 99%

“…Although PD is classically defined by the presence of general motor symptoms that include resting tremor, bradykinesia, rigidity, and postural instability, cranial motor deficits in the form of a hypokinetic dysarthria and dysphagia are reported to occur in 90% of PD patients (Sapir, Ramig, & Fox, 2008). These impairments have been documented to be associated with significant reductions in quality of life, social interactions and mental well-being (Plowman-Prine, Sapienza, et al, 2009). Alarmingly, aspiration pneumonia constitutes the leading cause of death in PD, resulting in a life expectancy ten years below the general population (Hely, Reid, Adena, Halliday, & Morris, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral and neurophysiological correlates of striatal dopamine depletion: A rodent model of Parkinson's disease

Plowman

Kleim

2011

Journal of Communication Disorders

View full text Add to dashboard Cite

Both limb and cranial motor functions are adversely impacted by Parkinson's disease (PD). While current pharmacological and surgical interventions are effective in alleviating general limb motor symptoms of PD, they have failed to provide significant benefit for cranial motor functions. This suggests that the neuropathologies mediating limb and cranial motor impairments in PD may differ. Animal models provide a mechanism by which the potential neural dysfunctions underlying these different motor impairments may be characterized. Central goals to our laboratory have been to (a) determine the differential responses of cranial motor and limb motor function to striatal dopamine depletion and (b) determine the differential effects of striatal dopamine depletion on the integrity of cranial motor and limb motor neural circuits. This paper details the use of a comprehensive battery of limb and cranial motor behavioral tasks and the application of intracortical microstimulation to assess corticospinal and corticobulbar circuits in a rodent model of PD. Our work suggests that striatal dopamine depletion does differentially affect cranial and limb motor function and corticospinal and corticobulbar circuits. Further, we propose that cranial motor impairments in PD may be mediated by pathology both within and outside nigrostriatal dopamine system. Learning outcomes Readers will be able to (a) describe a set of motor tests used to assess limb motor and cranial motor function in an animal model of Parkinson's disease, (b) understand the application of intracortical microstimulation to assess corticospinal and corticobulbar circuits, (c) describe the differential effects of dopamine depletion on limb motor and cranial motor function in a rodent model of PD, and (d) understand the potential role of dysfunction outside the nigrostriatal system mediating cranial motor impairments in Parkinson's disease.

show abstract

“…Dysarthria, a product of a movement disorder involving the muscles of the speech production mechanism [1], has been frequently identified in individuals with PD, with the majority of the studies reporting an increase of dysarthria prevalence in both numbers and severity with the progress of the disease [2, 3]. Previous studies reported that imprecision of consonant production is the most common articulatory impairment in individuals with PD who suffered a hypokinetic dysarthria [4–9]. Logemann and Fisher [10] reported that stops, affricates, and fricatives were often distorted in their participants with PD.…”

Section: Introductionmentioning

confidence: 99%

Lingual Kinematics in Dysarthric and Nondysarthric Speakers with Parkinson's Disease

Wong

Murdoch

Whelan

2011

Parkinson's Disease

View full text Add to dashboard Cite

Articulatory dysfunction is recognised as a major contributor to the speech disturbances seen in Parkinson's disease (PD). The present study aimed to compare lingual kinematics during consonant production within a sentence in eight dysarthric (DPD) and seven nondysarthric (NDPD) speakers with PD with those of eleven nonneurologically impaired normal participants. The tongue tip and tongue back movements of the participants during sentence production were recorded using electromagnetic articulography (EMA). Results showed that both the DPD and NDPD had deviant articulatory movement during consonant production that resulted in longer duration of consonant production. When compared with the NDPD group, the DPD group primarily exhibited increased range of lingual movement and compatible duration of production with an accompanying increase in maximum velocity, maximum acceleration, and maximum deceleration. These findings are contrary to proposed theories that suggest articulatory imprecision in dysarthric speakers with PD is the outcome of reduced range of articulatory movement.

show abstract

Perceptual characteristics of Parkinsonian speech: A comparison of the pharmacological effects of levodopa across speech and non-speech motor systems

Cited by 83 publications

References 71 publications

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

Behavioral and neurophysiological correlates of striatal dopamine depletion: A rodent model of Parkinson's disease

Lingual Kinematics in Dysarthric and Nondysarthric Speakers with Parkinson's Disease

Contact Info

Product

Resources

About