“…Most previous studies did not find correlation between audiometric threshold and other variables such as blood pressure, use of ototoxic drugs, weight changes, haematocrit and metabolic bone disease. This is similar to our findings, although our result may have been influenced by the use of audiometer as the only audiologic modality used to assess the patients while some other investigators used DPOAEs and PTA [4,[8][9][10][11]. They reported that DPOAE seem to be more sensitive to incipient cochlear damage than behavior thresholds [4,[8][9][10][11].…”
Section: Discussionsupporting
confidence: 87%
“…They concluded that the injury was associated with exposure to aged cellulose acetate membranes of dialyzers, allowing acetate degradation product to enter the blood. Temporal bone study revealing severe loss of hair cell in the organ of corti after polybrene administration have further confirmed the ototoxic effect of polybrene and other macromolecular substances [8,9]. We suspect that the observed depression in hearing threshold after hemodialysis in this study could be due to a combination of changes in fluid and electrolyte composition of endolymph and possibly exposure to aged cellulose acetate membranes of dialyzers used, allowing acetate degradation product to enter the blood, however this may need further confirmation with temporal bone study.…”
SUMMARYSensorineural hearing impairment (SHI) has been reported in chronic renal failure (CRF) patients with a prevalence of 20-40%. The aetiopathogenetic mechanisms reported included osmotic alteration resulting in loss of hair cells and in some, complications of haemodialysis have been hypothesized . We have in the past reported 2 cases of CRF patients who developed acute SHL following hemodialysis. This is a report of investigation of the effect of hemodialysis on the hearing function of CRF patients using pure tone audiometry findings. Thirty-three CRF patients were recruited for Pure Tone Audiometry (PTA) at admission and after three sessions of hemodialysis. The pure tone audiometry was done with a computer audiometer BA 20 Kamplex in the sound -proof (acoustic) booth in the ENT clinic. The duration of illness, dosage of diuretics and blood pressure were also noted. Similar age and sex-matched control were selected among volunteers who were otherwise clinically healthy. The data was processed using the Statistical Package for the Social Sciences (SPSS Inc, Chicago, Illinois, USA). Thirty-three CRF patients treated with haemodialysis and 28 healthy controls completed the study, 34 males and 27 females, age range was 16 -72 years, mean of 45.30 (SD16.20) for subjects and 49.7 for controls. Hearing loss was found in 22/34 (67%) at recruitment and 27/34 (79%) after 3 sessions of hemodialysis. There was a significant difference between the mean pre-and posthemodialysis PTA values, P =0.0008. There was also a significant correlation between posthemodialysis hearing threshold and (i) duration of illness (P = 0.00340) and (ii) creatinine levels of the patients (P=0.035). In conclusion, there was a significant depression in the hearing threshold of patients with CRF following three sessions of hemodialysis. This could be caused by changes induced by hemodialysis or effects of the duration and severity of disease.
“…Most previous studies did not find correlation between audiometric threshold and other variables such as blood pressure, use of ototoxic drugs, weight changes, haematocrit and metabolic bone disease. This is similar to our findings, although our result may have been influenced by the use of audiometer as the only audiologic modality used to assess the patients while some other investigators used DPOAEs and PTA [4,[8][9][10][11]. They reported that DPOAE seem to be more sensitive to incipient cochlear damage than behavior thresholds [4,[8][9][10][11].…”
Section: Discussionsupporting
confidence: 87%
“…They concluded that the injury was associated with exposure to aged cellulose acetate membranes of dialyzers, allowing acetate degradation product to enter the blood. Temporal bone study revealing severe loss of hair cell in the organ of corti after polybrene administration have further confirmed the ototoxic effect of polybrene and other macromolecular substances [8,9]. We suspect that the observed depression in hearing threshold after hemodialysis in this study could be due to a combination of changes in fluid and electrolyte composition of endolymph and possibly exposure to aged cellulose acetate membranes of dialyzers used, allowing acetate degradation product to enter the blood, however this may need further confirmation with temporal bone study.…”
SUMMARYSensorineural hearing impairment (SHI) has been reported in chronic renal failure (CRF) patients with a prevalence of 20-40%. The aetiopathogenetic mechanisms reported included osmotic alteration resulting in loss of hair cells and in some, complications of haemodialysis have been hypothesized . We have in the past reported 2 cases of CRF patients who developed acute SHL following hemodialysis. This is a report of investigation of the effect of hemodialysis on the hearing function of CRF patients using pure tone audiometry findings. Thirty-three CRF patients were recruited for Pure Tone Audiometry (PTA) at admission and after three sessions of hemodialysis. The pure tone audiometry was done with a computer audiometer BA 20 Kamplex in the sound -proof (acoustic) booth in the ENT clinic. The duration of illness, dosage of diuretics and blood pressure were also noted. Similar age and sex-matched control were selected among volunteers who were otherwise clinically healthy. The data was processed using the Statistical Package for the Social Sciences (SPSS Inc, Chicago, Illinois, USA). Thirty-three CRF patients treated with haemodialysis and 28 healthy controls completed the study, 34 males and 27 females, age range was 16 -72 years, mean of 45.30 (SD16.20) for subjects and 49.7 for controls. Hearing loss was found in 22/34 (67%) at recruitment and 27/34 (79%) after 3 sessions of hemodialysis. There was a significant difference between the mean pre-and posthemodialysis PTA values, P =0.0008. There was also a significant correlation between posthemodialysis hearing threshold and (i) duration of illness (P = 0.00340) and (ii) creatinine levels of the patients (P=0.035). In conclusion, there was a significant depression in the hearing threshold of patients with CRF following three sessions of hemodialysis. This could be caused by changes induced by hemodialysis or effects of the duration and severity of disease.
“…The association between renal disease and hearing deficits has been emphasized in several previous reports [4][5][6][7], Suggested causes of the hearing loss include ototoxic drug exposure (primarily aminoglycoside antibiotics, furo semide and ethacrynic acid), genetic renal disease [8], presbyacusis, noise exposure, in fection and circulating uremic toxins of chronic renal failure [9], Hypotension during dialysis in the presence of atherosclerotic vas cular disease may lead to vascular occlusion of vessels supplying inner ear structures [6], and electrolyte imbalances (notably hyponatremia) [5] are other potential causes which have been implicated in the loss of hearing acuity in this group of patients. In one report, use of the antiheparinizing drug polybrene was related to deafness [7].…”
In order to determine the effect of dialysis on hearing acuity, 20 patients on chronic maintenance hemodialysis or peritoneal dialysis were followed with hearing examinations every 6 months over a follow-up period of 1–4 years. While 70% of the study group had some measurable hearing loss at the beginning of the study, 75% of the patients showed no deterioration of hearing loss during the follow-up period. It is suggested that hearing deficits in chronic renal failure are common and multifactorial in etiology, and that most patients undergoing chronic dialysis show no further deterioration in hearing acuity.
“…On reviewing the available literatures, only 25 cases were found (one case by Ransome et al 1966 Is the hearing loss progressive ?…”
Section: Temporal Bone Findingsmentioning
confidence: 99%
“…Caution should be taken in using these drugs in cases of renal failure. Ransome et al (1966) reported that polybrene used during H.D. therapy causes ototoxicity.…”
vestibular tests were performed in 229 patients who were treated with hemodialysis (H.D.) and the following results were obtained.(1) One hundred and six patients exhibited bilateral hearing loss and 31 showed unilaterally impaired hearing.(2) Vestibular dysfunction was found in 83 patients.(3) Those who were impaired both in the cochlea and the vestibular organ were 60. (4) No correlations were observed between the occurrence rate of the inner ear dysfunction and Hct, BUN and serum creatinine levels. (5) The results in the present study did not suggest the possibility that the hearing loss was progressively getting worse during the period of H.D. therapy.Based on these results, the possible etiological factors in the inner ear dysfunction were discussed. ---------hemodialysis; inner ear dysfunction
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