For this study, the knowledge and utilization of Intermittent Preventive Treatment (IPT) for malaria control among pregnant women attending antenatal clinics in the Primary Health Care Centers in the Sunyani West District of Ghana was assessed. A cross-sectional descriptive survey was conducted to assess antenatal accessibility and practices of IPT, knowledge of pregnant women on IPT use, and the effectiveness of IPT towards the reduction of malaria in pregnancy. The researcher used both secondary and primary data to elicit information for the study. The tools for the primary data collection were structured questionnaire and focused group discussion. Data was collected in two health facilities in the Sunyani West. Data was analyzed using Statistical Package for Social Science (SPSS) version 20.0 and the results were presented using frequencies, graph, cross tabulation and level of association using Chi-square. The study shows that the knowledge and utilization of IPT among pregnant women in Sunyani West District were very low. Majority of the respondents (68.2%) did not have knowledge on ITP use. Thus at 95% confidence level, the proportion of those who did not have knowledge on IPT use and those who had was highly significant (p1≠P2). The major challenges that were identified to suppress the effectiveness of IPT utilization from the health care provider point of view included inadequate Antenatal Clinic trained staff, low facility coverage and late ANC reporting of pregnant women. This study, therefore, recommends that healthcare providers in the district should intensify education on the use of Intermittent Preventive Treatment of malaria in pregnant women through community durbars, and radio and Television programs.