Perceptions of Hong Kong Chinese women toward influenza vaccination during pregnancy

Yuen, Carol Yuet Sheung; Dodgson, Joan E.; Tarrant, Marie

doi:10.1016/j.vaccine.2015.11.032

Cited by 28 publications

(55 citation statements)

References 49 publications

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“…One of the most commonly provided reasons by the unvaccinated was that their doctor had not discussed during their pregnancy. The finding that more than one third of those unvaccinated did not receive a health care provider recommendation is in line with previous studies [34, 36, 41, 43, 44]. Another commonly provided reason was the concern that vaccination may not be safe during pregnancy.…”

Section: Discussionsupporting

confidence: 87%

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Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy

Napolitano

Angelillo

2017

BMC Infect Dis

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BackgroundThe aims of this study were to assess the knowledge, attitudes, and behaviors towards seasonal influenza and its vaccination among pregnant women.MethodsA cross-sectional survey was carried out among a sample of women in the second or third trimester of pregnancy in Italy.ResultsThe 64.2% of the sample knew that the influenza is more dangerous for pregnant women. Women of older age, Italian, and who had a pregnancy at high-risk were more likely to have this knowledge. This knowledge was lower among women with none, primary or secondary school education. The majority of the respondents considered the vaccine not very useful during pregnancy. Those younger, unmarried, who knew that influenza is more dangerous for pregnant women, who knew that the vaccine could protect them, who reported a higher self-rated health status, and who had received information about influenza and its vaccination were more likely to have a positive attitude toward the usefulness of influenza vaccination in pregnancy. Women with secondary school education and with more than one child revealed a lower perception. Only 9.7% had received the vaccine and 21.4% of those unvaccinated would be willing to receive it. This positive attitude was higher among women with one child, who knew that the vaccine could protect them against the influenza, and who have a positive attitude toward the usefulness of the vaccination during pregnancy.ConclusionsHealth educational programs are needed to improve the knowledge about seasonal influenza and vaccination rate in pregnancy.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2138-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 87%

“…Another commonly provided reason was the concern that vaccination may not be safe during pregnancy. Despite the extensive research demonstrating vaccine safety, this is alarming and this is accordance with previous studies [14, 17, 20, 40, 43, 45]. This stressed the role of the physicians.…”

Section: Discussionsupporting

confidence: 82%

Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy

Napolitano

Angelillo

2017

BMC Infect Dis

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“…Second, parents' positive views on the benefits of vaccinations in protecting their child and the community and ensuring their child's healthy development made them view vaccination as a parental and societal responsibility. Similar positive views were reported previously (Pal, Goodyear‐Smith, & Exeter, ; Yuen et al., ), and parents' greater perceived benefits and viewing vaccination as a social norm were likely to promote their adherence to vaccination of their child (Kennedy, LaVail, et al., ). Third, our participants also attributed high vaccination uptake to the accessibility and availability of vaccinations (Figueiredo, Pina, Tonete, de Lima, & de Mello, ; Pal et al., ).…”

Section: Discussionsupporting

confidence: 81%

“…Again, this could be attributed to the nonmandatory nature of the vaccinations in other countries. Third, for optional vaccinations, limited accessibility and low perceived severity of disease, such as the varicella and influenza vaccines, were associated with low uptake as shown in our study and previous studies (Bond & Nolan, ; Lugg et al., ; Pal et al., ; Yuen et al., ).…”

Section: Discussionsupporting

confidence: 66%

A descriptive qualitative study of perceptions of parents on their child's vaccination

Kurup

Wang

et al. 2017

Journal of Clinical Nursing

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“…While this platform has been extensively explored for Pfs25 [25–30] this is the first time Pfs48/45 DNA vaccines have been examined in pre-clinical studies. In a recent study, immunization with DNA plasmid encoding Pvs48/45 formulated with Vaxfectin in mice elicited antibodies with transmission reducing activity in the presence of complement, however no reduction was seen in heat-inactivated serum (complement negative) [50]. The goal of studies presented here was to investigate the vaccine potential of Pfs48/45 using a DNA vaccination approach.…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation

Datta

Bansal

Gerloff

et al. 2017

Vaccine

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Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system during infection in the human host also makes it ideal for natural boosting. However, it has been challenging to produce a fully folded, functionally active Pfs48/45, using various protein expression platforms. In this study, we demonstrate that full-length Pfs48/45 encoded by DNA plasmids is able to induce significant transmission reducing immune responses. DNA plasmids encoding Pfs48/45 based on native (WT), codon optimized (SYN), or codon optimized and mutated (MUT1 and MUT2), to prevent any asparagine (N)-linked glycosylation were compared with or without intramuscular electroporation (EP). EP significantly enhanced antibody titers and transmission blocking activity elicited by immunization with SYN Pfs48/45 DNA vaccine. Mosquito membrane feeding assays also revealed improved functional immunogenicity of SYN Pfs48/45 (N-glycosylation sites intact) as compared to MUT1 or MUT2 Pfs48/45 DNA plasmids (all N-glycosylation sites mutated). Boosting with recombinant Pfs48/45 protein after immunization with each of the different DNA vaccines resulted in significant boosting of antibody response and improved transmission reducing capabilities of all four DNA vaccines. Finally, immunization with a combination of DNA plasmids (SYN Pfs48/45 and SYN Pfs25) also provides support for the possibility of combining antigens targeting different life cycle stages in the parasite during transmission through mosquitoes.

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Perceptions of Hong Kong Chinese women toward influenza vaccination during pregnancy

Abstract: Vaccination promotion strategies need to focus on encouraging HCPs to take the initiative to discuss vaccination with their pregnant clients and provide accurate and unbiased information about the risks of influenza and the benefits of vaccination.

Cited by 28 publications

References 49 publications

Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy

Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy

A descriptive qualitative study of perceptions of parents on their child's vaccination

Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation

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