Perceptions of Egyptian physicians about drug shortage during political disturbances: Survey in Greater Cairo

Abdelrahman, Ammar A.; A, Saad; Sabry, Nirmeen A.; Farid, Samar

doi:10.1016/j.bfopcu.2016.05.004

Cited by 12 publications

(19 citation statements)

References 16 publications

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“…Three studies reported multiple impacts on ADRs. As above, the study by Abdelrahman et al [36] reported both increased and equivalent ADRs, as it gathered physicians’ perspectives and there was a proportion of respondents who agreed, disagreed or were neutral with the statements in the survey. Hall et al [29] reported both increased and decreased ADRs, where anaesthetic shortages were reported to increase post-operative complications, and fentanyl removal from epidurals resulted in less pruritis.…”

Section: Resultsmentioning

confidence: 97%

“…Of these, ten reported increased mortality [5, 13, 23–30], and five reported equivalent mortality [31–35]. One study, Abdelrahman et al [36] reported both increased and equivalent mortality, the majority of physicians agreed or were neutral regarding the statement that drug shortages resulted in patient deaths, however, there was also a proportion of physicians which disagreed. Medication classes that were commonly involved in poor patient outcomes during shortages included antimicrobials [28, 33, 37–39] and oncology medicines [24–27, 31, 32, 40–42].…”

Section: Resultsmentioning

confidence: 99%

“…Eight of these reported an increase in drug errors [13, 19, 23, 24, 26, 29, 42, 46]. The study by Abdelrahman et al [36] reported both increased and equivalent drug errors because it reported physicians’ perspectives.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to this long-term comparative study, others directly gathered physician perspectives on the relationships between drug shortages and mortality. This was the case in the study by Abdelrahman et al where approximately 1/3 of physicians stated that shortages caused death, 1/3 said they did not, and 1/3 responded neutrally on the survey tool [36]. These heterogeneous methods used to report the impact of shortages, again making it difficult to draw firm conclusions on true impacts, and more comprehensive studies comparing those receiving no drug, or alternative treatment are required to highlight the full clinical consequence of shortages.…”

Section: Discussionmentioning

confidence: 99%

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The impacts of medication shortages on patient outcomes: A scoping review

et al. 2019

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Background In recent years, medication shortages have become a growing worldwide issue. This scoping review aimed to systematically synthesise the literature to report on the economic, clinical, and humanistic impacts of medication shortages on patient outcomes. Methods Medline, Embase, Global Health, PsycINFO and International Pharmaceutical Abstracts were searched using the two key concepts of medicine shortage and patient outcomes. Articles were limited to the English language, human studies and there were no limits to the year of publication. Manuscripts included contained information regarding the shortage of a scheduled medication and had gathered data regarding the economic, clinical, and/or humanistic outcomes of drug shortages on human patients. Findings We found that drug shortages were predominantly reported to have adverse economic, clinical and humanistic outcomes to patients. Patients were more commonly reported to have increased out of pocket costs, rates of drug errors, adverse events, mortality, and complaints during times of shortage. There were also reports of equivalent and improved patient outcomes in some cases. Conclusions The results of this review provide valuable insights into the impact drug shortages have on patient outcomes. The majority of studies reported medication shortages resulted in negative patient clinical, economic and humanistic outcomes.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The impacts of medication shortages on patient outcomes: A scoping review

et al. 2019

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“…It is evident from this study that all patients attempted suicide. Abdelrahman et al (2016) explained it by social and economic instabilities in Egypt especially in the last few years. Kumar et al (2011) in India also explained it by social and economic instability of his population in addition to religious and cultural factors and availability of drugs.…”

Section: Discussionmentioning

confidence: 99%

Plasma MiRNA-208b as a Biomarker for Detection of Cardiotoxicity Induced by Acute Cardiovascular Drugs Poisoning

Hussien

Ashry

Agwa

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All rights reserved. Abstract:Background: Poisoning by cardiovascular drugs has harmful effects and may lead to morbidity and mortality. In cases of myocardial injury, circulating miRNA-208 levels elevate after their leakage into the bloodstream at an early stage of myocardial insult. This study aims to assess the possible role of miRNA-208b in the early detection of myocardial injury in acute intoxicated patients with cardiovascular drugs such as digoxin, beta blockers and calcium channel blockers.Methods: This study enrolled 40 patients with cardiovascular drug toxicity admitted to the Poison Control Center of Ain Shams University Hospitals (PCC-ASUH) from January 2016 to December 2016 in addition to 40 healthy subjects as the normal control group. Blood samples for miRNA-208b determination and troponin were collected on admission for the patients group and in the early morning for the control group. The demographic and clinical data were collected for every patient. Results: Age and sex distribution revealed that most of studied patients were in the age group of 18-24 years accounting for 50% with female predominance 85%. Beta blockers acute toxicity was the commonest cardiovascular drug toxicity (50%) followed by digitalis (35%) then calcium channel blockers (15%). The box plot outlook suggested that patients with a fold change in miRNA-208b higher than 1, was at risk of having a cardiac injury (ie. Troponin positive). Conclusion:This study concluded that miRNA-208b is a sensitive and specific biomarker in early detection of cardiac injury in patients with cardiovascular drugs poisonings for the early treatment of cardiotoxicity.

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Barriers toward xenotransplantation in Arab World

Ghazi,

Saleh,

Abdallah

et al. 2024

Xenotransplantation

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Organ transplant is a crucial therapeutic strategy offering a life‐saving and transformative medical intervention. It provides an opportunity to improve their quality of life and increase their lifespan. The shortage of organs remains a critical global challenge, leading to a prolonged waiting times for organ receivers, which contributes to an increase in morbidity and mortality rates. Hence, xenotransplantation offered a promising solution to the global shortage of organs through the use of animal organs, leading to an increase in donor availability, reducing waiting times, minimizing organ trafficking, improving genetic engineering advancements, and driving scientific innovation. Even though xenotransplantation has many benefits in the clinical setting, it has many barriers that are hindering its achievements and constraining its occurrence. Some barriers to xenotransplant are general, such as the immunological barrier, while others are specific to certain regions due to local causes. The Arab region exhibits disparities in clinical settings compared to the global context, marked by the huge economic crisis and a shortage of trained healthcare professionals. Considering the huge resources and advancements needed in the field of xenotransplantation, this review aims to explore the specific barriers toward xenotransplantation in the Arab countries, highlighting the challenges to overcome these barriers.

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Perceptions of Egyptian physicians about drug shortage during political disturbances: Survey in Greater Cairo

Cited by 12 publications

References 16 publications

The impacts of medication shortages on patient outcomes: A scoping review

The impacts of medication shortages on patient outcomes: A scoping review

Plasma MiRNA-208b as a Biomarker for Detection of Cardiotoxicity Induced by Acute Cardiovascular Drugs Poisoning

Barriers toward xenotransplantation in Arab World

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